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T1992 |
Mertansine
|
DM1,Maytansinoid DM1 |
Microtubule Associated
|
|
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4... |
|
T22136 |
PRL-3 Inhibitor I
|
PRL-3 Inhibitor,BR-1 |
Phosphatase
,
Others
|
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PRL-3 Inhibitor I (BR-1) is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells. |
|
T2586 |
Cabozantinib
|
XL184,BMS-907351 |
Apoptosis
,
VEGFR
,
FLT
,
c-Met/HGFR
,
c-RET
,
TAM Receptor
,
c-Kit
|
|
Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity... |
|
T5164 |
Cabozantinib hydrochloride
|
XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351 |
VEGFR
,
FLT
,
c-Met/HGFR
,
TAM Receptor
,
c-Kit
,
ROR
|
|
Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM). |
|
T77743 |
TT-012
|
|
Others
|
|
TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the g... |
|
T69447 |
APBC
|
|
|
|
APBC is a novel PD-L1 inhibitor, effectively interrupting the PD-1/PD-L1 interaction by directly binding to PD-L1, presenting the KD and IC50 values at low-micromolar level, displaying superior antitumor efficacy in hPD-... |
|
T82524 |
Dual photoCORM 1
|
|
|
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Dual photoCORM 1 (compound 5), a metal-free, photoactive, dual carbon monoxide releasing molecule (CORM), demonstrates efficient cellular uptake and enables real-time tracking of CO release via a colorimetric change in B... |
|
T79401 |
Tyrosinase-IN-13
|
|
Tyrosinase
|
|
Tyrosinase-IN-13 (compound 3c), stemming from Flurbiprofen, acts as a potent non-competitive inhibitor of tyrosinase, exhibiting IC50 and Ki values of 68 μM and 36.3 μM respectively. This compound demonstrates cytotoxici... |
|
T76072L |
CCZ01048 TFA
|
|
|
|
CCZ01048 TFA, an α-MSH analogue, demonstrates a strong binding affinity for the melanocortin 1 receptor (MC1R), displaying a K i value of 0.31 nM. It exhibits rapid internalization into B16F10 melanoma cells and maintain... |
|
T76072 |
CCZ01048
|
|
|
|
CCZ01048, an analogue of α-melanocyte-stimulating hormone (α-MSH), demonstrates a high binding affinity for the melanocortin 1 receptor (MC1R), with a Ki of 0.31 nM. It rapidly internalizes into B16F10 melanoma cells and... |
|
T75029 |
HEMTAC CDK4/6 degrader 1
|
|
|
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HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a K d value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests c... |
|
T69269 |
DMGF
|
|
|
|
DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, a... |
|
T64640 |
Melanin probe-2
|
|
|
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Melanoma is a lethal skin cancer. The early detection of melanoma using positron emission tomography (PET) probes is critical for improving the survival of melanoma patients. Melanin probe-2 is a non-radioactive bromo-pi... |
