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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8507 | MAC-545496 | Antibacterial | |
MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent. | |||
T1305 | Ceftazidime | GR20263 | Antibacterial , Antibiotic |
Ceftazidime (GR20263) is a beta-lactam, cephalosporin antibiotic with bactericidal activity. | |||
T18408 | N-Butanoyl-L-homoserine lactone | N-Butyryl-L-homoserine lactone,C4-HSL | Antibacterial |
N-Butanoyl-L-homoserine lactone is a degradable ADClinker used in the synthesis of antibody-coupled drugs. It can be used in antimicrobial biofilms and has antimicrobial activity. Its aptamer inhibits Pseudomonas aerugin... | |||
T83096 | Antibiofilm agent-2 | Others | |
Antibiofilm Agent-2 (Compound 4T) serves as a potent biofilm inhibitor, exhibiting an IC50 of 3.6 μM, and impairs the quorum sensing system along with iron homeostasis, acting as antibacterial synergists against Pseudomo... | |||
T84803 | Antibiofilm agent-1 | Others | |
Antibiofilm Agent-1, as detailed in WO2017011725A1 (compound 17) [1], serves as an antibacterial agent effective against Gram-positive pathogens. | |||
T12094 | Monobehenin | Others , Antibacterial | |
Monobehenin has a strong inhibitory effect on the formation of bacterial biofilm. | |||
T79468 | Antimicrobial agent-22 | THI 6c | Antibacterial |
Antimicrobial agent-22 (THI 6c) is an antimicrobial agent with low cytotoxicity, anti-biofilm activity and rapid bactericidal action. | |||
T13947 | Tween 80 | Others | |
Tween 80 is a nonionic surfactant and emulsifier that reduces bacterial adherence and inhibits biofilm formation. Tween 80 is widely used as a co-solvent in pharmacology experiments because of its ability to enhance the ... | |||
T35805 | C16 Sphingomyelin (d18:1/16:0) | Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin | Endogenous Metabolite |
C16 Sphingomyelin (d18:1/16:0) (N-Palmitoyl-D-sphingomyelin) is a phospholipid analog of phospholipid bilayer membranes, which can be used to study biofilm activity. | |||
TF0116 | LysoFos Choline 12 | 1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine | Others |
LysoFos Choline 12 (1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine) is an amphoteric surfactant that acts as a biofilm mimic for self-aggregation in aqueous solution. | |||
T78823 | Quorum Sensing-IN-3 | QS-IN-1 | Antibacterial |
Quorum Sensing-IN-3 (QS-IN-1) is a compound with inhibitory effects on bacterial community sensing, which inhibits the exchange of information between bacteria and inhibits biofilm formation. | |||
T13789 | N-dodecanoyl-L-Homoserine lactone | C12-HSL | Others |
N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule, a microbial communication mechanism modulated by acyl homoserine lactone (AHL) molecules impacts biofilm formation in bioreactors. | |||
T78226 | Methyl 2-amino-5-bromobenzoate | Methyl 5-Bromoanthranilate | HCV Protease , Antifungal |
Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) is a hepatitis C virus NS5b RNA polymerase inhibitor with antimicrobial activity that inhibits Pseudomonas aeruginosa infections and is involved in the producti... | |||
T77521 | HA5 | Antibacterial | |
HA5 has antimicrobial activity and inhibits the biofilm formation of Streptococcus mutans with an IC50 value of 6.42 μM. HA5 inhibits the production of Streptococcus mutans dextran and the level of eDNA, but it does not ... | |||
T124492 | Imipenem | N-Formimidoyl thienamycin,MK0787 | Antifungal |
Imipenem (MK0787) is a thienomycin derivative that belongs to the class of antibiotics with antibacterial activity and partial inhibition against gram-positive and gram-negative bacteria. Imipenem can be used to study ca... | |||
T36983 | Cyclic-di-GMP disodium | Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium | STING , Endogenous Metabolite |
Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP... | |||
T63894 | Octenidine | Others | |
Octenidine is an effective antibacterial agent that inhibits biofilm gene expression, disrupts biofilm formation and is able to inhibit multi-resistant Gram-negative pathogens. | |||
T13788 | N-Butanoyl-DL-homoserine lactone | (Rac)-C4-HSL | Others |
N-Butanoyl-DL-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa. | |||
T71508 | TCSA | Others | |
TCSA is an inhibitor of fungal morphogenesis, biofilm formation, and host cell invasion. | |||
T70386 | QZN34 | Others | |
QZN34 is a PqsR inhibitor which prevents S. aureus biofilm formation, severely damaged established S. aureus biofilms, and perturbed P. aeruginosa biofilm development. The mechanism of action of QZN 34 toward Gram-positi... | |||
T80123 | CRAMP (mouse) | ||
CRAMP (mouse), an antimicrobial peptide, is utilized in the study of biofilm-associated infections [1]. | |||
T61126 | Antibacterial synergist 1 | Others | |
Antibacterial synergist 1 (compound 20P) is a potent inhibitor of bacterial biofilm formation. It effectively suppresses the production of pyocyanin, with an IC 50 of 8.6 μM, and inhibits biofilm formation with an IC 50 ... | |||
T30767 | CB-181963 | CB 181963,CB181963,UNII-6784994L0W,CAB 175 | Others |
CB-181963, a new cephalosporin, is an effective antistaphylococcal drug, showing excellent activity against the resistance of MRSA strains to other cephalosporins in planktonic and biofilm cultures. | |||
T68343 | PyrD-IN-14 | Others | |
PyrD-IN-14 is an inhibitor of the PyrD protein (a dihydroorotate dehydrogenase (DHODase) involved in pyrimidine biosynthesis) which suppresses bacterial cytotoxicity, biofilm formation, and antibiotic resistance. | |||
T37555 | Cardanol triene | Others | |
Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal c... | |||
T74272 | Antifungal agent 84 | Others | |
Antibacterial Agent 84, an antifungal compound, effectively inhibits candidiasis through a CNB1-dependent mechanism and reduces the viability of the C. albicans biofilm [1]. | |||
T74820 | Antibacterial agent 142 | Others | |
Antibacterial agent 142, an aromatic hydrazide, exhibits bacteriostatic antibacterial activity and inhibits biofilm formation [1]. | |||
T37464 | CAY10711 | Others | |
CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displa... | |||
T71813 | Cardanol diene | Others | |
Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC50 value of 52.5 μM in vitro. Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E... | |||
T79555 | G43-C3-TEG | Others | |
G43-C3-TEG is a glycosyl-transferase inhibitor that diminishes biofilm formation by inhibiting the synthesis of extracellular polysaccharides (EPS) [1]. | |||
T61366 | F-17 | Others | |
F-17 is a promising virulence factor inhibitor, displaying substantial inhibitory effects on biofilm formation, elastase activity, pyocyanin production, and swarming motility. Additionally, F-17 exhibits a strong binding... | |||
T64029 | Antifungal agent 42 | Others | |
Antifungal agent 42 is an antifungal agent that has an inhibitory effect on biofilm formation. Antifungal agent 42 inhibits C.alb.'s lanosterol 14α-demethylase (CYP51). | |||
T63500 | Alexidine | Others | |
Alexidine is an antifungal and anti-biofilm agent against a variety of fungal pathogens. alexidine targets the mitochondrial tyrosine phosphatase PTPMT1 in mammalian cells, causing mitochondrial apoptosis and exhibiting ... | |||
T60610 | LasR-IN-4 | Others | |
LasR-IN-4 is a potent inhibitor of LasR which inhibits Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production [1]. | |||
T72333 | Antibacterial agent 64 | Others | |
Antibacterial agent 64, a potent YycG inhibitor (IC50=6.1 µM), serves as an effective antibacterial agent. When combined with ampicillin, it synergistically eradicates biofilm-embedded viable bacteria. | |||
T75176 | Antifungal agent 53 | Others | |
Antifungal Agent 53 (A03), a potent Candida albicans CYP51 inhibitor, exhibits antifungal activity by preventing fungi biofilm formation and demonstrates good safety [1]. | |||
T63711 | Antifungal agent 43 | Others | |
Antifungal agent 43 is an antifungal agent that exhibits antifungal effect by inhibiting biofilm formation. antifungal agent 43 shows low toxicity to human cancer cell lines. | |||
T61502 | Antifungal agent 32 | Others | |
Antifungal agent 32 (compound 1a) is a highly effective antifungal compound. It displays strong inhibitory activity against Candida albicans filamentation and biofilm formation, as well as inhibiting the morphological sw... | |||
T79561 | Mtb-IN-5 | Others | |
Mtb-IN-5 (compound (-)17j) is an isoxazole exhibiting anti-Mycobacterium tuberculosis (Mtb) activity. It impedes Mtb respiration and biofilm formation within macrophages and augments the efficacy of the antibiotic isonia... | |||
T37263 | 14-methyl Pentadecanoic Acid methyl ester | Others | |
14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluviali... | |||
T84471 | N-3-hydroxyoctanoyl-L-Homoserine lactone | OH-C8-HSL | Others |
N-3-hydroxyoctanoyl-L-Homoserine lactone, a small diffusible signaling molecule secreted by various bacteria, plays a critical role in quorum sensing—a regulatory system used by bacteria to control gene expression accord... | |||
T61108 | YXL-13 | Others | |
YXL-13 is a highly effective inhibitor of Pseudomonas aeruginosa (PAO1), with an IC50 value of 3.686 μM. It effectively hinders the expression of virulence factors and inhibits biofilm formation in PAO1. Moreover, YXL-13... | |||
T63285 | Antifungal agent 40 | Others | |
Antifungal agent 40 is an antifungal agent that extends into the narrow hydrophobic pocket II of C. alb. CYP51 and inhibits the activity of lanosterol 14α-demethylase (CYP51), which has an inhibitory effect on biofilm fo... | |||
T60291 | β-Nor-lapachone | Others | |
β-Nor-lapachone is an antibiofilm agent of Candida glabrata. β-Nor-lapachone can stimulate ROS production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. ... | |||
T37335 | N-3-hydroxybutyryl-L-Homoserine lactone | Others | |
N-3-hydroxybutyryl-L-Homoserine lactone is an N-acyl-homoserine lactone produced by the bacterium V. splendidus and has been found in sequencing batch biofilm reactors used in wastewater treatment.1,2 It is the racemic v... | |||
T83069 | Antifungal agent 75 | Others | |
Antifungal agent 75 (compound 6r) effectively combats Candida albicans by substantially inhibiting biofilm formation, enhancing cell membrane permeability, diminishing membrane ergosterol levels, impairing membrane struc... | |||
T74029 | Cis-11-Methyl-2-dodecenoic acid | Others | |
Cis-11-Methyl-2-dodecenoic acid functions as a quorum sensing (QS) signal and a diffusion signaling factor (DSF) within extracellular microbial and fungal communication systems. It plays a pivotal role in regulating viru... | |||
T72304 | Antibacterial agent 126 | Others | |
Antibacterial Agent 126 is a potent agent that not only reduces biofilm burden to prevent drug resistance development but also disrupts membrane integrity, resulting in the leakage of intracellular contents. Additionally... | |||
T76585 | Hepcidin-20 (human) | ||
Hepcidin-20 (human), a peptide characterized by its histidine content, cysteine-rich composition, and β-sheet structure, exhibits antifungal properties. Furthermore, it effectively inhibits biofilm formation and disrupts... | |||
T60965 | Anticandidal agent-1 | Others | |
Anticandidal agent-1 (compound c2) is a potent and broad-spectrum anticandidal agent that inhibits biofilm through blocking hyphal elongation and filamentation. Anticandidal agent-1 exhibits anticandidal activity against... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TN1545 | D-Tyrosine | Tyrosinase | |
D-Tyrosine, the D-isomer of tyrosine, acts as a negative regulator of melanin synthesis by inhibiting tyrosinase activity. Furthermore, D-Tyrosine also inhibits biofilm formation and induces the self-dispersal of biofilm... | |||
T36735 | 3,5-Di-tert-butylphenol | Reactive Oxygen Species , Antifungal | |
3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species. 3,5-Di-tert-butylphenol exhibits anti-biofilm and antifungal activities. | |||
T3S2340 | Usaramine | (15E)-Retrorsine,Mucronatine,NISTC15503874 | Others , Antibacterial |
Usaramine (Mucronatine) demonstrates phytotoxicity against Lactuca sativa var. Carrascoy (lettuce) assessed as inhibition of seed germination at 50 ug/cm2 after 24 hr. | |||
T3S1319 | (+)-Magnoflorine | Escholin,Magnoflorine,Thalictrin,Escholine | Others , Antifungal |
(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mech... | |||
T3S1320 | (+)-Magnoflorine iodide | Magnoflorine iodide,Thalictrine iodide,Corytuberine Methiodide | Others , Antifungal |
(+)-Magnoflorine iodide (Thalictrine iodide) has anti-inflammatory activity, it can inhibit inflammations. | |||
T4S1321 | (+)-Magnoflorine chloride | Magnoflorine chloride,Corytuberine methochloride,Thalictrine chloride,Escholine chloride | Others , Antifungal |
(+)-Magnoflorine chloride (Escholine chloride) has anti-inflammatory activity, it can inhibit inflammations. | |||
TQ0251 | (Z)-2-decenoic acid | (Z)-dec-2-enoic acid,cis-2-Decenoic acid,cis-dec-2-enoic acid | Others |
(Z)-2-decenoic acid (cis-dec-2-enoic acid) is an unsaturated short-chain fatty acid secreted by Pseudomonas aeruginosa. It can induce a dispersion response in biofilms formed by gram-negative and gram-positive bacteria. ... | |||
T8261 | Ceftazidime Pentahydrate | Antibacterial , Antibiotic | |
Ceftazidime is a β-lactam antibacterial agent which has demonstrated a broad spectrum of activity against Gram-positive and Gram-negative aerobic bacteria. | |||
T15254 | Ethyl acetoacetate | Ethyl acetylacetate | Others , Antibacterial |
Ethyl acetoacetate (Ethyl acetylacetate) is a bacterial biofilm inhibitor.Ethyl acetoacetate is an ester, an intermediate that can be used in the synthesis of many compounds. | |||
T5S0636 | Citric acid | Citro,Citretten | Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic |
1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili... | |||
T67731 | Holomycin | N-Demethylthiolutin | DNA/RNA Synthesis |
Holomycin (N-Demethylthiolutin) is a secondary metabolite of dithiopyrrolidone. HolomycinHolomycin, an antibiotic secondary metabolite, is required for the biofilm formation of natural photogenic Bacillus galatheae S2753... | |||
T6S2116 | Ginkgolic acid C17:1 | Phosphatase , PTEN | |
1. Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes. | |||
TN1925 | Methyl anthranilate | Others , Antibacterial | |
Methyl anthranilate is a natural product. Methyl anthranilate is a novel quorum sensing inhibitor and anti-biofilm agent against Aeromonas sobria | |||
T37753 | Aureusimine B | Cysteine Protease , Antibacterial | |
Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide syntheta... | |||
T73602 | Phosphorylcholine | Phosphocholine | Endogenous Metabolite |
Phosphorylcholine is widely present in the biological world, which is a phospholipid present in the eukaryotic biofilm, and also in the symbiotic bacteria or pathogens associated with eukaryotes. Phosphorylcholine has im... | |||
T6S2384 | Poliumoside | Reductase | |
Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase w... | |||
T38373 | 2-heptyl-3-hydroxy-4(1H)-Quinolone | 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal | Others |
2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) is a quorum-sensing signalling molecule produced by Pseudomonas aeruginosa in response to increased cell density. It increases the expression of the lasB ... | |||
T4723 | D-Tagatose | D-(-)-Tagatose,d-tagatos | Others , Endogenous Metabolite |
D-Tagatose (D-(-)-Tagatose), a rare natural hexoketose, is an isomer of d-galactose. D-Tagatose occurs naturally in Sterculia setigera gum, and it is also found in small quantities in various foods such as sterilized and... | |||
T10933 | D-Cysteine | Endogenous Metabolite , Antibacterial | |
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of the growth of E. coli. D-cysteine is mediated by D-amino acid oxidase to produce H2S, and is a neuroprotective agent against cerebellar ataxia. D-cystein... | |||
T72235 | Antibacterial synergist 2 | Others | |
Antibacterial synergist 2, functioning as a biofilm inhibitor, demonstrates inhibitory effects against pathogens such as S. enterica, S. aureus, P. aeruginosa, and C. albicans. This compound is applicable in research con... | |||
TN5466 | Boeravinone B | ||
Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for fur... | |||
T80018 | Cis-2-Dodecenoic acid | Others | |
Cis-2-dodecenoic acid, identified in Burkholderia cenocepacia, disrupts bacterial quorum sensing, thereby inhibiting biofilm formation and the production of virulence factors [1]. | |||
T72243 | Cyclic-di-GMP diammonium | 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium | Others |
Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species . | |||
T38241 | 2-Aminoimidazole | Others | |
2-Aminoimidazole is a potent antibiofilm agent and adjuvant to antimicrobial treatments, which effectively disrupts bacterial self-protection mechanisms by inhibiting biofilm formation and genetically-encoded antibiotic ... | |||
T64248 | Cyclic-di-GMP sodium | Others | |
Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility and virulence of various bacteria. | |||
TN1919 | (+)-Medioresinol | Medioresinol | Beta Amyloid , ROS , Antifection |
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α²-secretase, it is a potentially valuable anti... | |||
T35754 | Aszonapyrone A | Others | |
Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, ... | |||
T75967 | Bactenecin TFA | Others | |
Bactenecin TFA (Bactenecin, bovine TFA), a potent 12-aa looped antimicrobial peptide derived from bovine neutrophils, effectively inhibits bacterial and yeast growth and eradicates Trichophyton rubrum fungus. It enhances... | |||
T80001 | Majoranaquinone | Antibiotic | |
Majoranaquinone demonstrates potent antibacterial activity against four Staphylococcus strains, one Moraxella strain, and one Enterococcus strain. It also acts as an effective efflux pump inhibitor in Escherichia coli AT... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-00175 | YuaB Protein, Bacillus subtilis, Recombinant (His & SUMO) | Bacillus subtilis | E. coli |
Involved in biofilm formation. Self-polymerizes and forms a layer on the surface of biofilms that confers hydrophobicity to the biofilm. The layer is stable and capable of resistance to high mechanical force compression.... | |||
TMPH-03569 | IcaB Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli |
Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial ce... | |||
TMPH-00589 | SpoT Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli |
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response which coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme cataly... | |||
TMPH-03587 | GspB Protein, S. gordonii, Recombinant (GST) | Streptococcus gordonii | E. coli |
Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA. Plays a positive role in biofilm formation, possibly by self-a... | |||
TMPH-00712 | PGAB Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli |
Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide. N-deacetylation promotes PGA export through the PgaA porin. PGAB Protein, E. coli, Recombinant (His & Myc) is... | |||
TMPH-00331 | ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc) | Candida albicans | E. coli |
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans... |