| T5A2461 |
Bufotalin
|
Bufotaline |
Apoptosis
,
Others
,
Reactive Oxygen Species
|
|
1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads. |
| T4A2456 |
Gamabufotalin
|
Gamabufagin |
COX
|
|
1. Gamabufotalin (Gamabufagin) , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect. |
| T4A2399 |
Cinobufotalin
|
|
IL Receptor
,
Akt
,
MRP
,
P-gp
|
|
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent... |
| TN1200 |
19-Oxocinobufotalin
|
|
Others
|
|
19-Oxocinobufotalin 3-adipoylarginine ester shows significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro. |
| T83282 |
5β-Hydroxybufotalin
|
|
|
|
5β-Hydroxybufotalin (compound 6), a natural anticancer agent derived from the traditional Chinese medicine Ch'an Su [1], exhibits potent inhibitory effects on cancer cell proliferation. |
| TN1572 |
Desacetylcinobufotalin
|
|
Others
|
|
Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines. |
