|
T60658 |
HMAO-B/MB-COMT-IN-2
|
|
|
|
hMAO-B/MB-COMT-IN-2 is a dual inhibitor of MAO-B/MB-COMT with IC 50s of 4.27 μΜ and 2.69 μΜ for hMAO-B and MB-COMT, respectively. hMAO-B/MB-COMT-IN-2 protects cells from oxidative damage that can be used in the neurodege... |
|
T60489 |
HMAO-B/MB-COMT-IN-1
|
|
|
|
hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor with IC50s of 2.5 μΜ for hMAO-B and 3.84 μΜ for MB-COMT. hMAO-B/MB-COMT-IN-1 protects cells from oxidative damage that can be used in neurodegeneration disease resear... |
|
T16398 |
Opicapone
|
BIA 9-1067 |
Transferase
|
|
Opicapone (BIA 9-1067) reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research of Parkinson's disease and motor fluctuations. |
|
T7831 |
Nitecapone
|
|
Others
,
Transferase
|
|
Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver) |
|
T2216 |
Entacapone
|
OR-611 |
Transferase
|
|
Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). |
|
T6708 |
Tolcapone
|
Tasmar,Ro 40-7592 |
Apoptosis
,
Beta Amyloid
,
Transferase
|
|
Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor used in the therapy of Parkinson disease as adjunctive therapy in combination with levodopa and carbidopa. |
|
T4983 |
Isoetharine mesylate salt
|
Isoetarine mesilate |
Others
,
Adrenergic Receptor
|
|
Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist. it also is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression. |
|
T23109 |
3,5-Dinitrocatechol
|
|
Transferase
|
|
OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex. |
|
T75389 |
Catechol O-methyltransferase
|
|
|
|
Catechol O-methyltransferase (COMT) is a magnesium-dependent enzyme that mediates the transfer of methyl groups from S-adenosyl methionine to the hydroxyl group on dopamine, thus converting it to 3-methoxytyramine. COMT ... |
|
T24030 |
Entacapone acid
|
AG1290,AG 1290,AG-1290 |
Transferase
|
|
Entacapone acid (AG 1290) is a selective and reversible inhibitor of catechol-O-methyltransferase(COMT). |
|
T11207 |
Entacapone sodium salt
|
|
Others
|
|
Entacapone sodium salt inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapo... |
|
T26106 |
Ro 41-0960
|
Ro-41-0960,Ro41-0960 |
|
|
Ro 41-0960 is used as a reversible and orally-active COMT-inhibitor. |
|
T16279 |
Nebicapone
|
BIA 3-202 |
Others
|
|
Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ... |
|
T27162 |
DHMPA
|
|
|
|
DHMPA is an inhibitor of catechol-O-methyltransferase (COMT), it also reduces tissue norepinephrine and blood pressure. |
|
T29029 |
U-0521
|
|
|
|
U-0521, an inhibitor of catechol-O-methyltransferase (COMT), enhances the availability and utilization of levodopa in the brain. |
|
T70608 |
Cis-Entacapone
|
|
|
|
cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone. It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV li... |
|
T13181 |
Tolcapone D7
|
Ro 40-7592 D7 |
Transferase
|
|
Tolcapone D7 is a deuterium-labeled Tolcapone. Tolcapone is a selective and orally active inhibitor of COMT. |
|
T10119 |
3-O-Methyltolcapone
|
Ro 40-7591 |
Transferase
|
|
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of Parkinson's disease. |
|
T36207 |
Methylspinazarin
|
|
|
|
Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxyl... |
|
T10118 |
3-O-Methyltolcapone D7
|
Ro 40-7591 D7 |
Transferase
|
|
3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier... |
