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T9651 |
PD-1/PD-L1-IN-9
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PD-1/PD-L1
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PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in... |
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T72927 |
IMD-catechol
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NF-κB
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IMD-catechol is an innovative dimer compound combining an imidazoquinolinone structure with NF-κB immunomodulatory activity, which enhances treatment outcomes in a CT26 mouse colon carcinoma model and demonstrates low ad... |
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T34278 |
Redaporfin
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F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11 |
Others
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Redaporfin, also known as F-2BMet or LUZ-11, is a photosensitizer for Photodynamic Therapy (PDT) of cancer. Redaporfin showed a high efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26... |
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T79653 |
VISTA-IN-2
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Autophagy
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VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy, reverses VISTA-related immunosuppression, and fortifies the antitu... |
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T72056 |
KYN-101
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Others
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KYN-101 is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-medi... |
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T71884 |
ß-Carboline-1-carboxylic acid
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Others
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β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when u... |
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T83841 |
STING Agonist D61
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D61,Stimulator of Interferon Genes Agonist D61 |
Others
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STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular as... |
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T83779 |
EP4 Antagonist 14
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Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14 |
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EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A... |
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T36461 |
CAY10748
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CAY10748 |
Others
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CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, re... |
