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T11039 |
Didesethyl chloroquine
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Bisdesethylchloroquine |
Drug Metabolite
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Didesethyl chloroquine (Bisdesethylchloroquine) is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroquine. |
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T11001L1 |
N-Desethyl Chloroquine Hydrochloride
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(±)-Desethylchloroquine 2HCl |
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N-Desethyl Chloroquine Hydrochloride ((±)-Desethylchloroquine 2HCl) is a desethylchloroquine derivative. desethylchloroquine competitively inhibits cyp2d1 /6-mediated reactions in vitro and in vivo. |
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T0194L2 |
Chloroquine dihydrochloride
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Chloroquine HCl,NSC 14050,Aralen hydrochloride,NSC14050,Chloroquine hydrochloride,Aralen HCl,NSC-14050 |
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Chloroquine is a medication preventing and treating malaria in areas where malaria is known to be sensitive to its effects. It is also sometimes used for amebiasis that is occurring outside the intestines, rheumatoid art... |
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T11001L |
Desethyl chloroquine diphosphate
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Others
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Desethyl chloroquine diphosphate is the main deethyl metabolite of chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Chloroquine diphosphate has anti-plasma activity. |
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T11001 |
Desethyl chloroquine
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Monodesethylchloroquine,N-deethylchloroquine |
Parasite
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Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity. |
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T83602 |
(+)-Chloroquine
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(+)-Chloroquine, an aminoquinoline drug, inhibits the in vitro terminal glycosylation of angiotensin-converting enzyme 2 (ACE-2) [1]. |
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T0951 |
Hydroxychloroquine sulfate
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Acidum iopanoicum,HCQ sulfate |
DNA
,
SARS-CoV
,
TLR
,
Parasite
,
Autophagy
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Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in ... |
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T9287 |
Hydroxychloroquine
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2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol |
SARS-CoV
,
TLR
,
Parasite
,
Autophagy
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Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It i... |
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T73963 |
Hydroxychloroquine Impurity E
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Hydroxychloroquine Impurity E, an impurity found in Hydroxychloroquine, a synthetic antimalarial compound that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling, has been shown to effectively inhibit SARS-CoV-2 inf... |
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T73964 |
Hydroxychloroquine Impurity F
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Hydroxychloroquine Impurity F, an impurity in Hydroxychloroquine, is identified in the synthetic antimalarial agent known for its capability to inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Additionally, Hydroxychlo... |
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T12799 |
(S)-Hydroxychloroquine
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(S)-HCQ |
Others
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(S)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine shows efficiently inhibits SARS-CoV-2 infection in vitro. |
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T12622 |
(R)-Hydroxychloroquine
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(R)-HCQ |
Others
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(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is an agent of synthetic antimalarial. |
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T10835L1 |
Cletoquine hydrochloride
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Cletoquine hydrochloride( 4298-15-1 Free base) |
Influenza Virus
,
Parasite
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Cletoquine hydrochloride is a major active metabolite of Hydroxychloroquine. Cletoquine hydrochloride is a Chloroquine derivative and exhibits the ability to against the chikungunya virus (CHIKV). Cletoquine hydrochlorid... |
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T15276 |
Ferroquine
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SSR97193,Ferrochloroquine |
Others
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Ferroquine (Ferrochloroquine) is a ferrocenyl analogue of Chloroquine with antimalarial activity. Ferroquine induces oxidative stress and the subsequent destruction of the membrane, resulting in parasiticidal effect on P... |
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T3437 |
Lys05
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Lys01 trihydrochloride |
lysosomal autophagy
,
Autophagy
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Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compa... |
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T3266 |
Lumefantrine
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Benflumetol,dl-Benflumelol |
Others
,
Parasite
,
Autophagy
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Lumefantrine (dl-Benflumelol) is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects again... |
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T20910 |
Dibemethine
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Dibemetina,DBMA,AI3-26795,Dibemethinum |
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Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT). |
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T73845 |
Piperaquine tetraphosphate
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Piperaquine tetraphosphate, a potent antimalarial agent, demonstrates inhibitory effects against both chloroquine-sensitive and chloroquine-resistant malaria isolates. When combined with dihydroartemisinin, it holds pote... |
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T71619 |
ST72
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ST72 is a potent inhibitor of FP2. ST72 exhibited strong growth inhibition of chloroquine-sensitive (3D7; EC50 = 2.8 µM) and chloroquine-resistant (RKL-9; EC50 = 6.7 µM) strains of Plasmodium falciparum |
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T11006 |
Desmethyl ferroquine
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SSR97213 |
Others
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Desmethyl ferroquine is the active and major metabolite of Ferroquine.Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains. Ferroquine is an antimalarial. |
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T78966 |
Antiparasitic agent-17
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Parasite
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Antiparasitic Agent-17 (compound 5u), an orally active antiparasitic, demonstrates inhibition against both Chloroquine-sensitive (Pf3D7) and Chloroquine-resistant (PfK1) strains, with IC50 values of 0.96 μM and 1.67 μM, ... |
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T28937 |
Tebuquine
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WR-228,258,WR 228,258,CI 897,CI897,CI-897 |
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Tebuquine is an antimalarial agent. Tebuquine is active against P. falciparum in vitro. Tebuquine in vitro shows a chloroquine-like effect, but not in vivo, suggesting that its mode of action in vivo is different from th... |
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T63393 |
Halofantrine
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Halofantrine is an antimalarial active substance that is highly lipophilic and has a blocking effect on HERG potassium channels against the Chloroquine resistant Plasmodium falciparum. |
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T35484 |
5,7,8-Trimethoxydictamnine
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5,7,8-Trimethoxydictamnine is a quinoline alkaloid that has been found inRutaceaeand has antimalarial activity.1It is active against chloroquine-sensitive and -resistant strains ofP. falciparum(IC50s =19.9 and 5.72 μg/ml... |
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T76580 |
Antioxidant agent-9
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Antioxidant Agent-9, a peptide featuring the Asp-Trp sequence, exhibits antioxidant properties and demonstrates potential as an antiviral against SARS-CoV-2, possessing an affinity strength comparable to that of Chloroqu... |
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T83899 |
N-didesmethyl Loperamide
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R 21345 |
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N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the s... |
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T79632 |
Antileishmanial agent-21
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Parasite
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Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin.... |
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T35732 |
Diacetylcercosporin
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Diacetylcercosporin is a perylenequinone produced by Cercospora and Septoria that has diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive and resistant to chloroquine and L. ... |
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T35909 |
Penicinoline
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Penicinoline is an alkaloid that has been found in Penicillium and has antimalarial, insecticidal, and anticancer activities.1,2 It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = ... |
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T38297 |
Ribavirin-13C5
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Ribavirin-13C5 |
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Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to a... |
