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T74287 |
MGlc-DAG
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MGlc-DAG, a glycoglycerolipid, serves as a precursor in the synthesis of drug delivery compounds [1]. |
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T78669 |
(1R,4S)-Yimitasvir diphosphate
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(1R,4S)-DAG-181 diphosphate,(1R,4S)-Emitasvir diphosphate |
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Yimitasvir diphosphate, also known as Emitasvir, is an orally-administered inhibitor of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A). It is utilized in the study of chronic hepatitis C virus infections [1]... |
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T22465 |
1,2-Distearoyl-sn-glycerol
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Others
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1,2-Distearoyl-sn-glycerol is an internal standard for the isolation and characterization of molecular species of 1,2-diacyl-sn-glycerol (DAG). |
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T8369 |
Adagrasib
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MRTX849 |
Ras
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Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib ... |
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T27119L |
(Rac)-Daglutril
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SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid |
Others
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(Rac)-Daglutril (SLV 306 acetic acid) is the racemate form of Daglutril. Daglutril is an orally active, mixed neutral endopeptidase/endothelin converting enzyme inhibitor under development for the treatment of essential ... |
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T10954 |
DAGLβ-IN-1
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Others
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DAGLβ-IN-1 is a universal intermediate for designing DAGL tailored activity-based probes, and is an inhibitor of diacylglycerol lipase-β (DAGLβ). |
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T1502 |
Vildagliptin
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NVP-LAF 237,LAF237 |
Apoptosis
,
Ferroptosis
,
Proteasome
,
DPP-4
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Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit... |
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T11015 |
Midaglizole hydrochloride
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(±)-DG5128,(±)-DG5128 hydrochloride,DG5128 hydrochloride,DG5128 |
Adrenergic Receptor
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Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenocepto... |
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T80237 |
NODAGA-LM3
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NODAGA-LM3, when labeled with ^68Ga, serves as a PET imaging agent. As an SSTR2 antagonist, ^68Ga-NODAGA-LM3 is utilized for the visualization of SSTR-positive paragangliomas [1] [2]. |
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T61076 |
Vildagliptin dihydrate
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Vildagliptin dihydrate (LAF237 dihydrate) is a powerful and stable dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating selectivity with an IC50 of 3.5 nM in human Caco-2 cells. This compound exhibits exceptional or... |
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T27239 |
Edaglitazone
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Edaglitazone sodium,BM-13.1258,RO-2052349-602,R-483,RO-2052349-000 |
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Edaglitazone is a PPARγ agonist. Edarglitazone restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse. |
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T15340 |
Fosdagrocorat
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PF-04171327 |
Others
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Fosdagrocorat is an agonist of the dissociated glucocorticoid receptor. |
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T68098 |
Midaglizole
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(±)-DG5128 free base,DG5128 free base,(±)-DG5128 free base ; DG5128 free base |
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Midaglizole ((±)-DG5128 free base, DG5128 free base) is a powerful α2-adrenoceptor antagonist that acts as a hypoglycemic agent by increasing blood pressure and lowering blood glucose levels in vivo. |
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T15048 |
Dagrocorat
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PF-00251802 |
Others
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Dagrocorat is a novel and dissociated agonist of glucocorticoid receptor. |
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T31191L |
Dagapamil
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Dagapamilum |
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Dagapamil is a calcium-channel blocker. Dagapamil is claimed to have antihypertensive, antiarrhythmic, cardioprotective, antiallergic and platelet aggregation-inhibiting action in animal models. |
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T33939 |
Dagrocorat hydrochloride
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PF-0251802,PF 0251802,PF-0251802 HCl,PF0251802 |
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PF-0251802 HCl is a bio-active chemical. |
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T31191 |
Dagapamil hydrochloride
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Dagapamil hydrochloride is a calcium-channel blocker. Dagapamil hydrochloride is claimed to have antihypertensive, antiarrhythmic, cardioprotective, antiallergic and platelet aggregation-inhibiting action in animal model... |
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T35815 |
Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)
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Vildagliptin carboxylic acid metabolite is the major metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor vildagliptin in humans. Vildagliptin carboxylic acid metabolite has an IC50 value of 477 μM for DPP-4 in hum... |
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T27119 |
Daglutril
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SLV306,SLV 306,SLV-306 |
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Daglutril, a NEP/ECE inhibitor, is potentially used for the treatment of hypertension, heart failure andpulmonary. Daglutril inhibits systemic conversion of big endothelin-1 in humans. |
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T31133 |
Cyclo-cadagac
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Cyclo cadagac |
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Cyclo-cadagac is a cyclic heptapeptide. |
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T80238 |
NODAGA-LM3 TFA
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NODAGA-LM3 TFA, a SSTR2 antagonist, can be radiolabeled with ^68Ga for PET imaging applications, particularly in the visualization of SSTR-positive paragangliomas [1] [2]. |
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T28444 |
PPZ1
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PPZ 1,PPZ-1 |
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PPZ1 is a novel DAG-activated TRPC3/TRPC6/TRPC7 channels activator. |
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T33814 |
OptoDArG
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Opto-DArG,Opto DArG |
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OptoDArG is a diacylglycerol (DAG) photoswitch, which enables efficient control of TRPC3 by light. |
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T71755 |
QNN33358
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QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist. |
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T28445 |
PPZ2
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PPZ-2,PPZ 2 |
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PPZ2 is a novel DAG-activated TRPC3/TRPC6/TRPC7 channels activator. |
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T40757 |
1-Stearoyl-2-arachidonoyl-sn-glycerol
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1-Stearoyl-2-arachidonoyl-sn-glycerol, a diacylglycerol (DAG) encompassing polyunsaturated fatty acids, possesses the ability to activate PKC. Moreover, this compound has the potential to enhance nonselective cation chan... |
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T37030 |
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
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PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) |
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dio... |
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T37122 |
1,2-Dilinoleoyl-sn-glycerol
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1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (18:2) side chains attached at both the sn-1 and sn-2 positions. It has been found as a component of phosphatidic acid in rat liver mitochondria an... |
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T36907 |
1-Oleoyl Lysophosphatidic Acid
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Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid |
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1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through ... |
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T36937 |
PtdIns-(1,2-dioctanoyl) (sodium salt)
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl... |
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T36938 |
PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)
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PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt) |
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dio... |
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T35786 |
O-7460
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In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (... |
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T82007 |
JH-131e-153
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JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈R592A≈W588A. This compound’s C1 domain shares homology in seq... |
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T36939 |
PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
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PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) |
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, als... |
