|
T10057 |
LTD4 antagonist 1
|
|
Others
|
|
LTD4 antagonist 1 is a potent and orally active antagonist of leukotriene D4 (LTD4; Ki: 0.57 nM). |
|
T38128 |
Leukotriene D4
|
Leukotriene D4 MaxSpec® Standard,LTD4 |
Others
|
|
Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4... |
|
T30828 |
CGP 35949
|
CGP-35949,Cgp-35949,Cgp35949,CGP35949 |
Leukotriene Receptor
|
|
CGP 35949 is an LTD4 antagonist with phospholipase inhibitory activity. |
|
T27979 |
Masilukast
|
ICI-D-3523,ZD-3523,ICI D-3523,MCC-847,SA-09012,D-3523 |
Leukotriene Receptor
|
|
Masilukast(MCC-847) is an oral leukotriene D4 (LTD4) receptor antagonist for the study of diseases associated with inflammation. |
|
T14326 |
AS-35
|
|
Leukotriene Receptor
|
|
AS-35 is an orally available, selective and potent leukotrienes antagonist that inhibits LTC4, LTD4 and LTE4-induced ileus contractions.AS-35 has antiallergic properties and inhibits leukotriene synthesis. |
|
T26519 |
Ablukast
|
Ro 23-3544 |
Leukotriene Receptor
|
|
Ablukast (Ro 23-3544) is a leuktriene receptor antagonist. Ablukast acts as an anti-asthmatic. |
|
T10501 |
YM158 free base
|
YM-57158 |
Others
|
|
YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87). |
|
T3148 |
MK-571 sodium
|
L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid |
Leukotriene Receptor
,
LTR
|
|
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... |
|
T10873 |
CP-96486
|
|
Others
|
|
CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM). |
|
T10054 |
CI-949
|
|
Others
|
|
CI-949 is an allergic mediator release inhibitor, which inhibits leukotriene C4/D4 (LTC4/LTD4), histamine, and thromboxane B2 (TXB2) release (IC50s: 0.5 μM, 11.4 μM and 0.1 μM). |
|
T15647 |
Tipelukast
|
MN 001,KCA 757 |
Leukotriene Receptor
|
|
Tipelukast (KCA 757) is a novel orally available leukotriene receptor antagonist with anti-inflammatory activity that reduces fibrosis and down-regulates TIMP-1, type 1 collagen.Tipelukast is used in the study of asthma. |
|
T27912 |
LY 290324
|
LY-290324,LY290324 |
Others
|
|
LY 290324 is an orally active, potent and selective antagonist of cysteinyl leukotriene (LTD4) receptor. |
|
T37493 |
11-trans Leukotriene D4
|
11-trans Leukotriene D4 |
Others
|
|
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency fo... |
|
T10872 |
CP-96021 hydrochloride
|
|
Others
|
|
CP-96021 hydrochloride is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor receptor (Kis: 34 nM and 37 nM). |
|
T27877 |
LY 163443
|
LY163443,LY-163443 |
Others
|
|
LY 163443 is an dual receptor antagonist of LTD4 and LTE4. |
|
T71499 |
NZ-107
|
|
Others
|
|
NZ-107 is an LTB4, LTC4 and LTD4 antagonist. |
|
T10872L |
CP 96021
|
|
5-HT Receptor
|
|
CP 96021 is a group of 5-HT1 receptors and 5-HT2 receptors antagonists that have anti-inflammatory properties and are non-non-self anti-ulcer compounds for the treatment of gastrointestinal tract and respiratory asthma. |
|
T16739 |
RG-12525
|
NID 525 |
Leukotriene Receptor
,
PPAR
|
|
RG-12525（NID 525） is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guinea pig thin-walled bands, with IC50 values of 2.6 nM, 2.5 nM... |
|
T37261 |
14,15-Leukotriene D4
|
14,15-Leukotriene D4 |
Others
|
|
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 ... |
|
T38129 |
Leukotriene F4
|
LTF4 |
Others
|
|
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contrac... |
|
T0694 |
Pranlukast
|
ONO-1078 |
Leukotriene Receptor
,
IL Receptor
,
Others
,
TNF
,
NF-κB
,
LTR
|
|
Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered aller... |
|
T19674 |
Verlukast
|
MK 0679,MK-679,L 668,019,MK 679,L 668019,L-668,019 |
Others
|
|
Verlukast is an (R)-enantiomer of MK-571 and a potent and selective LTD4 receptor antagonist. Verlukast showed [3H]leukotriene D4 binding in guinea-pig (IC50 = 3.1 +/- 0.5 nM) and human (IC50 = 8.0 +/- 3.0 nM) lung homog... |
|
T63291 |
Pranlukast hemihydrate
|
|
Others
|
|
Pranlukast hemihydrate is a selective, potent and competitive antagonist of leukotriene.Pranlukast inhibits [3H]LTE4 (Ki: 0.63±0.11 nM), [3H]LTD4 (Ki: 0.99±0.19 nM) and [3H]LTC4 (Ki: 5640 ±680 nM) were bound to the lung ... |
|
T40870 |
Leukotriene E4
|
LTE4 |
Endogenous Metabolite
|
|
Leukotriene E4 (LTE4) (LTE4) is produced by the action of dipeptidyl peptidase on LTD4 and is a component of the Slow Reactive Substance of Anaphylaxis (SRS-A).LTE4 is present in plasma and urine and can be used to detec... |
|
T37652 |
5(S),6(R)-DiHETE
|
|
Others
|
|
5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It ... |
|
T37980 |
N-methyl Leukotriene C4
|
N-methyl Leukotriene C4 |
Others
|
|
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione t... |
|
T37262 |
14,15-Leukotriene E4
|
14,15-Leukotriene E4 |
Others
|
|
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metaboli... |
|
T36618 |
Rupatadine
|
|
Others
|
|
Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited ... |
