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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T9614	MERS-CoV-IN-1		SARS-CoV
	MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus.It is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS).		SARS-CoV
T7766	Remdesivir	GS-5734	SARS-CoV , DNA/RNA Synthesis
	Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viru...		SARS-CoV , DNA/RNA Synthesis
T72231	SARS-CoV-2/MERS Mpro-IN-2
	SARS-CoV-2/MERS Mpro-IN-2 is a potent inhibitor of the main proteases of SARS-CoV-2 and MERS, demonstrating IC50 values of 0.21 and 0.07 µM, respectively.
T72230	SARS-CoV-2/MERS Mpro-IN-1
	SARS-CoV-2/MERS Mpro-IN-1 is a potent inhibitor of the main proteases in SARS-CoV-2 and MERS, exhibiting IC50 values of 0.10 and 0.06 µM, respectively.
T60085	MM3122	GTPL11533,MM-3122,Ac-GQFR-kbt	SARS-CoV
	MM3122 (MM-3122) is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.		SARS-CoV
T8498	EIDD-1931	Beta-d-N4-hydroxycytidine	Virus Protease , HCV Protease , SARS-CoV , Topoisomerase
	EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndr...		Virus Protease , HCV Protease , SARS-CoV , Topoisomerase
T60951	Molnupiravir	EIDD-2801,Lagevrio,MK-4482	SARS-CoV , Influenza Virus
	Molnupiravir (MK-4482) (EIDD-2801) is a prodrug of the ribonucleoside analog EIDD-1931 which is orally bioavailable. Molnupiravir can be used in COVID-19, seasonal and pandemic influenza research that has broad spectrum ...		SARS-CoV , Influenza Virus
T6573	E 64c	NSC 694279,EP 475,Loxistatin Acid	SARS-CoV , Cysteine Protease
	E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.		SARS-CoV , Cysteine Protease
T36652	Anti-MERS-3A1 mAb	Anti-MERS-3A1 mAb
	Anti-MERS-3A1 mAb (MERS-3A1) is a high-affinity human monoclonal IgG1 antibody derived from CHO cells. It effectively inhibits the interaction between the MERS-CoV spike protein and the DPP4 receptor[1].
T12836	SARS-CoV-2-IN-1		Others
			Others
T68674	Vincapusine
	Vincapusine is a natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro.
T78867	WU-04		SARS-CoV
	WU-04 is a non-covalent inhibitor targeting the 3CLpro protein of SARS-CoV-2, demonstrating high inhibitory effects on 3CLpro from six SARS-CoV-2 variants (Alpha, Beta, Gamma, Delta, Lambda, and Omicron) as well as two o...		SARS-CoV
T72313	SARS-CoV-2 3CLpro-IN-11
	SARS-CoV-2 3CLpro-IN-11(11d) is a broad-spectrum antiviral compound that effectively inhibits the SARS-CoV-2 3CL protease, achieving an IC50 of 140 nM. Additionally, it exhibits inhibitory activity against SARS-CoV-1 and...
T39334	Remdesivir nucleoside monophosphate
	Remdesivir nucleoside monophosphate, a metabolite of Remdesivir, is a potent antiviral compound with nucleoside analogue characteristics. It exhibits effective antiviral activity against both SARS-CoV and MERS-CoV.
T76669	Anti-MERS-D12 mAb
	Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12), a human monoclonal IgG1, specifically targets the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD). By directly binding to this region, it effec...
T69547	UAWJ9-36-3
	UAWJ9-36-3 is a SARS-CoV-2 Protease inhibitor (IC50 = 54 nM). UAWJ9-36-3 showed potent binding and enzymatic inhibition against the Mpro's from SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HK...
T69548	UAWJ9-36-1
	UAWJ9-36-1 is a SARS-CoV-2 Protease inhibitor (IC50 = 51 nM). UAWJ9-36-1 showed potent binding and enzymatic inhibition against the Mpro's from SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HK...
T72312	SARS-CoV-2 3CLpro-IN-10
	SARS-CoV-2 3CLpro-IN-10(5d) is a potent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an IC50 value of 190 nM, and demonstrates varied efficiency against other coronaviruses with IC50 values of 790 nM for SARS-CoV...
T79339	NSC89641		SARS-CoV
	NSC89641 demonstrates potent inhibition of MERS-CoV M^pro, achieving an IC_50 value of less than 3.5 µM. Furthermore, it exerts significant inhibitory effects on SARS-CoV-2 M^pro enzymatic activity, with an IC_50 of 3.05...		SARS-CoV
T70451	Blancoxanthone
	Blancoxanthone is a molecule isolated from plants could also be potential drug candidates against COVID-19. Moreover, these could also show promising inhibitory effects against influenza-parainfluenza viruses, respirator...
T73973	Imatinib Impurity E
	Imatinib Impurity E is a specific impurity found in Imatinib, an orally available inhibitor of multiple tyrosine kinases, including BCR/ABL, v-Abl, PDGFR, and c-kit. Imatinib (STI571) operates by semi-competitively inhib...
T74467	Remdesivir de(ethylbutyl 2-aminopropanoate)
	Remdesivir de(ethylbutyl 2-aminopropanoate) is a recognized impurity in Remdesivir, a nucleoside analog demonstrating potent antiviral efficacy. It exhibits EC50 values of 74 nM against SARS-CoV and MERS-CoV in human air...
T38174	Mpro inhibitor N3 hemihydrate
	Mpro inhibitor N3 hemihydrate is a potent antagonist of the SARS-CoV-2 main protease (Mpro), demonstrating an EC50 of 16.77 μM against SARS-CoV-2. It exhibits specific inhibition of Mpro in a range of coronaviruses, incl...
T68485	Apilimod HCl
	Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits c...

Compounds

MERS-CoV-IN-1

Target: SARS-CoV, DNA/RNA Synthesis

SARS-CoV-2/MERS Mpro-IN-2

T72231

Synonym:

Target:

SARS-CoV-2/MERS Mpro-IN-1

Synonym: GTPL11533,MM-3122,Ac-GQFR-kbt

Target: SARS-CoV

EIDD-1931

T8498

Synonym: Beta-d-N4-hydroxycytidine

Target: Virus Protease, HCV Protease, SARS-CoV, Topoisomerase

Molnupiravir

T60951

Synonym: EIDD-2801,Lagevrio,MK-4482

Target: SARS-CoV, Influenza Virus

E 64c

T6573

Synonym: NSC 694279,EP 475,Loxistatin Acid

Target: SARS-CoV, Cysteine Protease

Anti-MERS-3A1 mAb

T36652

Synonym: Anti-MERS-3A1 mAb

SARS-CoV-2 3CLpro-IN-11

T72313

Synonym:

Target:

Remdesivir nucleoside monophosphate

SARS-CoV-2 3CLpro-IN-10

Remdesivir de(ethylbutyl 2-aminopropanoate)

T74467

Synonym:

Target:

Mpro inhibitor N3 hemihydrate

カタログ番号	製品名	別名	ターゲット
T3374	Dihydrotanshinone I	DHTS,15,16-dihydrotanshinone I	SARS-CoV , ROS
	Dihydrotanshinone I (DHTS) is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.		SARS-CoV , ROS
TN3528	Bonducellpin D		Antifection
	Bonducellpin D may show inhibitory activities on the Para3 virus. It also exhibits moderate activity against four tested human cancer cell lines, HepG-2, K562, HeLa, and Du145.		Antifection

天然物製品

Dihydrotanshinone I

T3374

Synonym: DHTS,15,16-dihydrotanshinone I

Target: SARS-CoV, ROS

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03423	MERS-CoV Nucleocapsid Protein (His)	MERS-CoV	Baculovirus-Insect Cells
	Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both vi...
TMPY-03574	MERS-CoV Spike/S1 Protein (aa 1-725, His)	MERS-CoV	HEK293
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-03512	MERS-CoV Spike/S2 Protein (aa 726-1296, His)	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-00402	MERS-CoV Spike/RBD Protein fragment (aa 367-606, His)	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-03661	MERS-CoV Spike Protein (S1+S2 ECD, aa 1-1297, His)	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-05818	MERS-CoV Spike/RBD Protein fragment (aa 367-606, His), Biotinylated	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-06225	MERS-CoV Spike Protein (aa 367-606, His & Avi), Biotinylated	MERS-CoV	HEK293
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-03228	MERS-CoV Spike/RBD Protein fragment (aa 367-606, rFc)	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPY-06170	MERS-CoV Spike S1+S2 Protein (aa 1-1297, His), Biotinylated	MERS-CoV	Baculovirus-Insect Cells
	The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;...
TMPK-00582	MASP2 Protein (Primary Amine Labeling), Rat, Recombinant (His), Biotinylated	Rat	E. coli
	The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is ...
TMPK-00496	MASP2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	E. coli
	The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is ...
TMPK-00581	MASP2 Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is ...
TMPK-01126	MASP2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is ...
TMPY-05693	SARS-CoV-2 Methyltransferase/ME Protein (His)	SARS-CoV-2	E. coli
	Coronavirus encodes the 2’-O-MTase (2'O Methyltransferase) that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate...
TMPH-01619	LY6E Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane...