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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T4965 | TCS-OX2-29 | OX Receptor | |
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1. | |||
T4965L | TCS-OX2-29 HCl | TCSOX 229,TCS-OX229,TCS OX229,TCS OX2 29,TCSOX-229,TCSOX229 | |
TCS-OX2-29 is a selective orexin-2 receptor antagonist (IC50 = 40 nM), which plays an important role in pain modulation. | |||
T1823 | IOX2 | IOX 2,JICL38 | HIF/HIF Prolyl-Hydroxylase |
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM). | |||
T82630 | CysOx2 | ||
CysOx2 is a fluorogenic probe designed for the detection of sulfenic acid, exhibiting an excitation/emission profile of 394/535 nm. It is specifically utilized for monitoring protein cysteine oxidation within living cell... | |||
T62855 | OX2R-IN-1 | ||
OX2R-IN-1 is an OX2R antagonist (a potential OX2R binding agent) that exhibits low cytotoxicity (IC50: 484 μM). oX2R-IN-1 has blood-brain barrier permeability and a short drug half-life. | |||
T81648 | NOX2-IN-1 | ||
NOX2-IN-1 (compound 10) serves as an inhibitor of the enzyme nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2). It specifically disrupts the p47phox-p22phox protein-protein interaction, exhibiting high... | |||
T81647 | NOX2-IN-2 | ||
NOX2-IN-2 (compound 33) is a potent inhibitor of NOX2, disrupting the p47phox-p22phox protein-protein interaction with a dissociation constant (K i) of 0.24 μM. It effectively suppresses reactive oxygen species (ROS) pro... | |||
T2613 | Almorexant | ACT 078573 | OX Receptor |
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T2710 | TCS 1102 | DORA-1 | OX Receptor |
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). | |||
T5503 | IPSU | OX Receptor | |
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. | |||
TP1045L | Orexin B, rat, mouse Acetate | Rat orexin B,Orexin B (mouse) Acetate,Orexin B, rat, mouse Acetate(202801-92-1 free base) | OX Receptor |
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. | |||
TP1973L | OXA (17-33) acetate | OX Receptor | |
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM). | |||
T5498 | SB-649868 | GSK649868 | OX Receptor |
SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). | |||
T11186 | EMPA | OX Receptor | |
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively) | |||
T6658 | SB-408124 | OX Receptor | |
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. | |||
T1913 | MK-3697 | OX Receptor | |
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM). | |||
TP1975L | [Ala11,D-Leu15]-Orexin B acetate | [Ala11,D-Leu15]-Orexin B acetate (532932-99-3 Free base) | OX Receptor |
[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM). | |||
T16096 | Filorexant | MK-6096 | OX Receptor |
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM). | |||
T16854 | SB-674042 | SB674042 | OX Receptor |
SB-674042 is a potent and selective dual antagonist of the non-peptide orexigenic peptides OX1 and OX2 receptors, with IC50s of 3.76 nM and 531 nM, respectively.SB-674042 can be used for the treatment of depression. | |||
T6140 | SB-334867 free base | SB334867A free base,SB-334867,SB 334867,SB334867 | OX Receptor |
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist. | |||
T39229 | YNT-185 | OX Receptor | |
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of ... | |||
T12877L | Seltorexant | JNJ-42847922 | OX Receptor |
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... | |||
T6155 | Almorexant hydrochloride | ACT-078573 hydrochloride,Almorexant HCl | OX Receptor |
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T37112 | YNT-185 dihydrochloride | ||
Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depo... | |||
T22880 | JNJ-10397049 | JNJ 10397049 | Others |
OX2 receptor antagonist | |||
TP1975 | [Ala11,D-Leu15]-Orexin B(human) | [Ala11,D-Leu15]-Orexin B | |
Highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively. | |||
T75921 | [Ala11,D-Leu15]-Orexin B(human) TFA | ||
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent, selective agonist for the orexin-2 receptor (OX2), demonstrating 400-fold higher selectivity for OX2 (EC 50 =0.13 nM) compared to the orexin-1 receptor (OX1) with an EC 50... | |||
TP1045 | Orexin B, rat, mouse | Orexin B (mouse),Rat orexin B | |
Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. | |||
T75920 | Orexin B, human TFA | ||
Orexin B, human (TFA), functions as a native agonist for the Orexin receptor, exhibiting dissociation constants (Kis) of 420 nM for OX1 and 36 nM for OX2, respectively. | |||
TP1138 | Orexin B, human TFA (205640-91-1 free base) | Orexin B, human TFA,Human orexin B TFA | |
Orexin B, human (TFA) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2. | |||
T75922 | OXA(17-33) TFA | ||
OXA(17-33) TFA is a potent, selective agonist for the orexin-1 receptor (OX1), demonstrating about 23-fold higher affinity for OX1 (EC50 = 8.29 nM) compared to the orexin-2 receptor (OX2) (187 nM) [1]. | |||
TP1973 | OXA(17-33) | OXA (17-33) | |
Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A. | |||
TP1139 | Orexin B, human | Human orexin B | |
Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. Orexin B is a hypothalamatic neuropeptide stimulating food intake in rats. | |||
T75925 | Orexin B, rat, mouse TFA | ||
Orexin B, rat, mouse (Rat orexin B) TFA, an endogenous agonist for orexin receptors, binds to and activates the closely related orphan G protein-coupled receptors OX1-R and OX2-R. This compound is instrumental in stimula... | |||
TP1550 | Orexin A (human, rat, mouse) (TFA) | ||
Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and o... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-05446 | CD200 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD200 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.2 kDa and the accession number is A0A2R9ADU6. | |||
TMPY-01160 | CD200 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD200 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is O54901.1. | |||
TMPY-05638 | CD200 Protein, Human, Recombinant (hFc & Avi) | Human | HEK293 Cells |
CD200 Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 51 kDa and the accession number is P41217-2. | |||
TMPK-00733 | CD200 Protein, Mouse, Recombinant (aa 31-232, His) | Mouse | HEK293 Cells |
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 rece... | |||
TMPY-01071 | CD200 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD200 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P41217-2. | |||
TMPY-06791 | CD200 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
CD200 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.71 kDa and the accession number is NP_005935.4. | |||
TMPK-00476 | CD200 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 rece... | |||
TMPJ-00233 | CD200R1/CRTR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain ... | |||
TMPH-01277 | ENOX2 Protein, Human, Recombinant | Human | E. coli |
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a ... | |||
TMPH-01278 | ENOX2 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a ... |