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T10560 |
P2X3 antagonist 34
|
BLU-5937 |
|
|
P2X3 antagonist 34, a potent, selective, and orally active antagonist, targets the P2X3 homotrimeric receptor, exhibiting IC50s of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors respectively. It s... |
|
T78606 |
P2X3-IN-1
|
|
P2X Receptor
|
|
P2X3-IN-1 (example 7) is a P2X3 receptor inhibitor suitable for research on neurogenic diseases [1]. |
|
T79115 |
P2X3 antagonist 38
|
|
P2X Receptor
|
|
Compound 38, also known as Compound 4, is a potent, orally active P2X3 antagonist that demonstrates inhibitory activity with IC50 values of 0.132 µM, 0.165 µM, and 0.421 µM against human (hP2X3), rat (rP2X3), and guinea ... |
|
T63197 |
P2X3 antagonist 36
|
|
|
|
P2X3 antagonist 36 is a P2X3 antagonist. |
|
T9519 |
Eliapixant
|
BAY 1817080 |
P2X Receptor
|
|
Eliapixant (BAY 1817080) (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough. |
|
TQ0002 |
A-317491
|
ABT 202 |
P2X Receptor
|
|
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors. |
|
T5099 |
Gefapixant
|
RO 4926219,AF219,MK-7264 |
P2X Receptor
|
|
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. |
|
T2087 |
AF-353
|
Ro-4 |
P2X Receptor
|
|
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0). |
|
T8946 |
Indophagolin
|
|
P2X Receptor
,
5-HT Receptor
,
Autophagy
|
|
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. |
|
T40045 |
Sivopixant
|
S-600918,Sivopixant |
P2X Receptor
|
|
Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect . |
|
T67885 |
Camlipixant
|
BLU-5937 |
P2X Receptor
|
|
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment o... |
|
T5513 |
RO-3
|
|
P2X Receptor
|
|
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor |
|
T9653 |
(E/Z)-Sivopixant
|
(E/Z)-S-600918 |
P2X Receptor
|
|
(E/Z)-Sivopixant ((E/Z)-S-600918)is a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research. |
|
T34081 |
Piromelatine
|
NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor
,
5-HT Receptor
,
MT Receptor
,
Sodium Channel
,
TRP/TRPV Channel
|
|
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... |
|
T23245 |
Ro-51
|
Ro 51 |
Others
|
|
dual P2X3 and P2X2/3 antagonist |
|
TP2273 |
NF110
|
NF 110 |
Others
|
|
P2X3 antagonist |
|
T71373 |
MK-3901
|
|
|
|
MK-3901 is a P2X3 antagonist. |
|
T23442 |
TC-P 262
|
|
Others
|
|
P2X3 and P2X2/3 receptor antagonist |
|
T13541 |
α,β-Methylene ATP trisodium
|
|
Others
|
|
α,β-Methylene ATP trisodium is a ligand of P2X3 and P2X7 receptor. |
|
T33506 |
MRS2220
|
MRS 2220,MRS-2220 |
|
|
MRS2220 is a selective enhancer of the ATP effects at fast desensitizing P2X (P2X1 and P2X3) receptors. |
|
T38444 |
α,β-Methylene-ATP dilithium
|
|
|
|
α,β-Methylene ATP dilithium, a phosphonic analog of ATP, serves as a ligand for P2X3 and P2X7 receptors. It is a potent agonist specifically targeting P2X1 and P2X3 receptors while exerting negligible activity on P2X2, P... |
|
T72590 |
α,β-Methylene-ATP
|
|
|
|
α,β-Methylene ATP, a phosphonic analog of ATP, functions as a ligand for P2X3 and P2X7 receptors. This compound acts primarily as a selective agonist for P2X1 and P2X3 receptors, exhibiting minimal to no activity on P2X2... |
|
T37392 |
Purotoxin 1
|
|
|
|
Purotoxin 1, isolated from wolf spider venom, is a P2X3 receptor inhibitor that exhibits antinociceptive activity in animal models of inflammatory pain. |
|
TQ0002L |
A-317491 sodium
|
A-317491,A 317491,A317491 |
|
|
A-317491 is an effective selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, which reverses inflammatory mechanical hyperalgesia and relieves chronic inflammation and neuropathic pain in rats by acting on p... |
|
T10204 |
A-317491 sodium salt hydrate
|
A-317491 sodium salt hydrate (475205-49-3 free base) |
Others
|
|
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. |
|
TP2272 |
NF023 hexasodium
|
NF 023,NF 023 hexasodium |
P2X Receptor
|
|
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. |
|
T63846 |
Gefapixant citrate
|
|
|
|
Gefapixant citrate is an orally active P2X3 receptor (P2X3R) antagonist that acts on human homologous recombinant hP2X3 (IC50: ~30 nM) and hP2X2/3 (IC50: 100-200 nM). gefapixant citrate can be used to study chronic cough... |
|
T64078 |
MRS2179 tetrasodium hydrate
|
|
|
|
MRS2179 tetrasodium hydrate, a competitive antagonist of the P2Y1 receptor, acts on the turkey P2Y1 receptor (Kb: 102 nM, pA2: 6.99) and exhibits an inhibitory effect on platelet aggregation. IC50: 1.15 μM), P2X3 (IC50: ... |
|
T8333 |
Aurintricarboxylic acid
|
ATA,NSC-4056,NSC4056,NSC 4056 |
Apoptosis
,
P2X Receptor
,
Influenza Virus
,
Topoisomerase
|
|
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. |
|
T9833 |
Opiranserin hydrochloride
|
|
P2X Receptor
,
GlyT
,
5-HT Receptor
|
|
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50... |
|
T83802 |
TNP-ATP sodium
|
|
|
|
TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2/3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to... |
|
T10466 |
BAY-1797
|
|
P2X Receptor
|
|
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak activity on the other P2X ion channels. |
|
T16399 |
Opiranserin
|
|
P2X Receptor
,
GlyT
,
5-HT Receptor
|
|
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) an... |
