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Search Results for " TMP "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T13172L1	TMP-778		ROR
	TMP-778 is a selective inverse agonist of RORγt.		ROR
T36126	TMP-153		Acyltransferase
	TMP-153 is a novel and potent ACAT inhibitor with an IC50 value of 5-10 nM for intestinal and hepatic ACAT in animals.TMP-153 has a hypocholesterolemic effect, inhibiting cholesterol uptake and lowering plasma cholestero...		Acyltransferase
T13174	TMPyP4 tosylate	TMP 1363	DNA/RNA Synthesis , Telomerase
	TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.		DNA/RNA Synthesis , Telomerase
T3983	TMP195	TFMO 2,TMP 195	HDAC
	TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.		HDAC
T31017	Coumarin-TMP-Halo	Coumarin TMP Halo,CTH
	Coumarin-TMP-Halo is a specific fluorescent protein labeling agent.
T34893	TMP-NVOC-Halo	TNH
	TMP-NVOC-Halo is a caged protein labeling agent.
T1857	TMP269		HDAC
	TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively.		HDAC
T78534	NVOC cage-TMP-Halo		Others
	NVOC cage-TMP-Halo is a photoactivatable, cell-permeable inducer of protein dimerization that enables rapid and reversible modulation of protein localization within living cells, with applications in dynamic cellular pro...		Others
T80972	TNH	TMP-NVOC linker-Halo
	TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].
T24899	Trimosulfa	Trimethoprim-sulfamethoxazole,Sulfamethoxazole-trimethoprim,TMP-SMX,Trimforte,Trimethoprimsulfa
	Trimosulfa is a fixed antibiotic combination that widely used for mild-to-moderate bacterial infections and as prophylaxis against opportunistic infections.
T83821	Thymidine-5'-O-(α,β-methylene)diphosphate sodium	α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP
	Thymidine-5’-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM). It serves as a precursor in the synthesis of α,β-methylene-2’-deo...
T17108	TMP920		ROR
	TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.		ROR
T13172L	TMP778		Others
	TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).		Others
T13172	TMP780		ROR
	TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.		ROR
T60080	TMPH	2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR
	TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.		AChR
T13173	TMPA		Others , AMPK
	TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.		Others , AMPK
T40732	TMPD dihydrochloride
	TMPD dihydrochloride is an active substrate of enzymatically convert redox and an electron donor for the reduction of heme peroxidases.
T61796	MtTMPK-IN-1
	MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demon...
T61573	MtTMPK-IN-5
	MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhib...
T61781	MtTMPK-IN-6
	MtTMPK-IN-6 (compound 1) is a highly effective inhibitor (IC 50 = 29 μM) of M. tuberculosis thymidylate kinase (Mtb TMPK). It is a valuable compound for tuberculosis research [1].
T27314	Fe-TMPyP
	Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
T35966	Mn(III)TMPyP
	Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-...
T63657	MtTMPK-IN-9
	MtTMPK-IN-9 is a moderately potent inhibitor of Mycobacterium thymidylate kinase (MtbTMPK) (IC50: 48 μM).MtTMPK-IN-9 has submicromolar activity against Mycobacterium but no significant cytotoxicity.MtTMPK-IN-9 can be use...
T63639	MtTMPK-IN-7
	MtTMPK-IN-7 is a moderately potent inhibitor of Mycobacterium brevis thymidylate kinase (MtbTMPK) (IC50: 47 μM).MtTMPK-IN-7 exhibits submicromolar activity against Mycobacterium brevis with MICs ranging from 2.3 to 4.7 μ...
T63491	MtTMPK-IN-8
	MtTMPK-IN-8 is a moderately potent inhibitor of Mycobacterium thymidylate kinase (MtbTMPK) with no significant cytotoxicity, exhibiting submicromolar activity (MICs = 0.78-9.4 μM) against Mycobacterium and capable of bei...
T28986	TMPPAA
	TMPPAA is an allosteric agonist of 5-HT3 receptor.
T62897	MtTMPK-IN-3
	MtTMPK-IN-3 (compound 25) is a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK) with an IC50 value of 0.12 μM. It also demonstrates inhibitory activity against Mtb H37Rv with a MIC of 12.5 μM an...
T23462	TMPH hydrochloride		Others
	neuronal nicotinic ACh receptors (nAChRs) antagonist		Others
T61780	MtTMPK-IN-4
	MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory...
T62305	MtTMPK-IN-2
	MtTMPK-IN-2 (compound 15), a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), demonstrates an IC50 value of 1.1 μM. This compound effectively inhibits Mtb H37Rv with a minimum inhibitory conce...
T78238	4′-DTMP	4-Demethyltrimethoprim	DHFR , Antifungal
	4′-DTMP (4-Demethyltrimethoprim) is a potent DHFR inhibitor with antimicrobial activity that induces additional local interactions with the enzyme and inhibits Escherichia coli.		DHFR , Antifungal

Compounds

Target: Acyltransferase

TMPyP4 tosylate

T13174

Synonym: TMP 1363

Target: DNA/RNA Synthesis, Telomerase

TMP195

T3983

Synonym: TFMO 2,TMP 195

Target: HDAC

Coumarin-TMP-Halo

T31017

Synonym: Coumarin TMP Halo,CTH

TMP269

Synonym: TMP-NVOC linker-Halo

Target:

Trimosulfa

T24899

Synonym: Trimethoprim-sulfamethoxazole,Sulfamethoxazole-trimethoprim,TMP-SMX,Trimforte,Trimethoprimsulfa

Target:

Thymidine-5'-O-(α,β-methylene)diphosphate sodium

T83821

Synonym: α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP

TMP920

TMP778

TMP780

TMPH

Synonym: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

TMPA

TMPD dihydrochloride

TMPPAA

Synonym: 4-Demethyltrimethoprim

Target: DHFR, Antifungal

カタログ番号	製品名	別名	ターゲット
T4730	Thymidine-5'-monophosphate disodium salt	Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT	Others , Endogenous Metabolite
	Thymidine-5'-monophosphate disodium salt (TMP DISODIUM SALT) is found in DNA. In mammalian cells, thymidine deprivation induces chromosome aberrations such as chromatid breaks, chromatid interchanges, and chromosome frag...		Others , Endogenous Metabolite
T4558	Trioxsalen	Trimethylpsoralen,Trioxysalen,Trisoralen	DNA Alkylator/Crosslinker , DHFR
	Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...		DNA Alkylator/Crosslinker , DHFR
T7892	ATMP		Others
	ATMP is a phosphonic acid with chelating properties. It is an antiscalant.		Others
T0572	Methyl 3,4,5-trimethoxybenzoate	Methyl gallate trimethyl ether,Methyl EudesMate,3,4,5-Trimethoxybenzoic acid methyl ester,Methyl tri-O-methylgallate,Trimethylgallic acid methyl ester	Others
	Methyl 3,4,5-trimethoxybenzoate (Methyl EudesMate) is the intermediate of antibacterial efficiency medicine trimethoprim.		Others
T83320	4'-Demethylpodophyllotoxone
	4'-Demethylpodophyllotoxone, an intermediate in the biotransformation pathway of Alternaria alternata S-f6, undergoes further modification with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP). This modification yields a novel ...
T75540	Ipomoeassin F
	Ipomoeassin F, a selective and potent inhibitor of endoplasmic reticulum (ER) protein translocation, targets the Sec61 complex's pore-forming subunit (Sec61α) at the ER membrane. It inhibits the ER membrane translocation...

天然物製品

Thymidine-5'-monophosphate disodium salt

T4730

Synonym: Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT

Target: Others, Endogenous Metabolite

Trioxsalen

T4558

Synonym: Trimethylpsoralen,Trioxysalen,Trisoralen

Target: DNA Alkylator/Crosslinker, DHFR

Methyl 3,4,5-trimethoxybenzoate

T0572

Synonym: Methyl gallate trimethyl ether,Methyl EudesMate,3,4,5-Trimethoxybenzoic acid methyl ester,Methyl tri-O-methylgallate,Trimethylgallic acid methyl ester

Target: Others

4'-Demethylpodophyllotoxone

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00499	TMP21 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long r...
TMPH-03643	TmpB Protein, Treponema phagedenis, Recombinant (His & Myc)	Treponema phagedenis	E. coli
	Tmp may serve as a porin or transport protein for large molecules. TmpB Protein, Treponema phagedenis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecula...
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02239	TMPRSS4 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC.; (Microbial infection) In gut epithelia...
TMPH-02238	TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated	Human	E. coli
	TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated is expressed in E. coli expression system with N-MBP and C-6xHis-Avi tag. The predicted molecular weight is 90.6 kDa and the accession number is O15393.
TMPH-02235	TMPRSS2 Protein, Human, Recombinant (Cell-Free, His)	Human	E. coli
	TMPRSS2 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.9 kDa and the accession number is O15393.
TMPY-04928	TMPRSS11B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TMPRSS11B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.3 kDa and the accession number is CAD91168.1.
TMPY-04985	TMPRSS11D Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TMPRSS11D (HAT) belongs to the large type II transmembrane serine protease (TTSP) family, participating in various biological and physiological processes. TMPRSS11D protein expression in tumorous tissues were correlated ...
TMPJ-00960	TMPO Protein, Human, Recombinant (His)	Human	E. coli
	Thymopentin is a member of the LEM family. Thymopentin is expressed in many tissues, highly in the adult thymus and fetal liver. The N-terminal contains two structurally independent domains, LEM domain and LEM-like domai...
TMPY-01041	Compound TMPY-01041

TMPH-02234	TMPRSS11A Protein, Human, Recombinant (His)	Human	E. coli
	Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
TMPH-02945	TMPRSS4 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC. TMPRSS4 Protein, Mouse, Recombinant (Hi...
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...