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T34862 |
Thromboxane A2
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Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2 |
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Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction. |
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T12268 |
NTP42
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Prostaglandin Receptor
,
PPAR
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NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM) |
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T6236 |
Ozagrel
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OKY-046,Domenan |
Thrombin
,
Prostaglandin Receptor
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Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral isch... |
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T6625 |
Ozagrel hydrochloride
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Ozagrel HCl,OKY-046 HCl |
Thrombin
,
Prostaglandin Receptor
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Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. |
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T10783 |
CGS 15435
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PPAR
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CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase. |
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T68022 |
Sulotroban
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PPAR
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sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation. |
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T25741 |
Linotroban
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HN 11500,CL-871502 |
PPAR
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Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity. |
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T27630 |
Isbogrel
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CV4151,CV-4151,CV 4151 |
Prostaglandin Receptor
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Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks and thrombosis. |
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T11825 |
LCB-2853
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PPAR
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T11339L |
Furegrelate
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PPAR
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FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. |
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T31213 |
Dazmegrel
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UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485 |
PPAR
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Dazmegrel (UK 38,485) is a potent and specific thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy. |
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T15577 |
Indobufen
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Ibustrin |
COX
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Indobufen (Ibustrin) is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue fac... |
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T11339 |
Furegrelate sodium
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U-63557A |
PPAR
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T15049 |
Daltroban
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BM-13505,SKF 96148 |
PPAR
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Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist. Daltroban shows protective effect in reperfusion injury. Daltroban increase intracellular calcium in vascular smooth muscle cells. |
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T68086 |
Imitrodast
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Thrombin
|
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Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and cardiovascular diseases, and can be used in studies of arterial th... |
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T0212 |
Seratrodast
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AA 2414,ABT-001 |
COX
,
Prostaglandin Receptor
,
PPAR
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Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist developed as an anti-asthmatic drug and attained ma... |
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T67959 |
Pirodomast
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Thrombin
,
Serine Protease
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Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospas... |
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T17039 |
Terbogrel
|
BIBV 308SE |
Prostaglandin Receptor
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T24542 |
NP-313
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NP 313,NSC 4264,NSC-4264,NSC4264 |
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NP-313 (NSC-4264) is a potent antithrombotic agent that inhibits platelet aggregation and activation by inhibiting thromboxane A 2 synthesis and selectively inhibiting SOCC-mediated Ca2+ efflux. |
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T2396 |
Ramatroban
|
BAY u3405 |
GPR
,
Prostaglandin Receptor
,
PPAR
|
|
Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma. |
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T10501 |
YM158 free base
|
YM-57158 |
Others
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YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87). |
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T71035 |
KT2-962
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KT2-962 is a TXA2/prostaglandin endoperoxide receptor antagonist. |
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T34710 |
STA 2
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ONO 11113,STA-2,STA2 |
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STA 2 is an analogue of TXA2, a thromboxane receptor in the colonic epithelium. |
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T69400 |
Fenalcomine
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Fenalcomine inhibits the action of prostaglandins on smooth muscle but stimulates TXA2. |
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T27588 |
Ifetroban
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BMS180291,BMS-180291,BMS 180291-02 |
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Ifetroban is a potent and selective TxA2/PGH2 receptor antagonist. |
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T28176 |
Nizofenone
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Y9179,Y-9179,Ekonal,Y 9179 |
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Nizofenone, a thromboxane A2 (TXA2) biosynthesis inhibitor, is used as a neuroprotective drug and used to treat stroke. |
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T15252 |
Etersalate
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Etherylate,Eterylate |
Others
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T69404 |
Fenalcomine hydrochloride
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Fenalcomine hydrochloride inhibits the action of prostaglandins on smooth muscle but stimulates TXA2. |
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T24157 |
Ici D1542
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D 1542,D1542,Ici-D1542,ZD 1542 |
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Ici D1542 is a drug that exhibits both potent, selective TXS inhibition and TXA2 receptor antagonism. Ici D1542 is an effective thromboxane A2 synthase inhibitor and receptor antagonist in vitro. |
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T17189 |
U-46619
|
9,11-Methanoepoxy PGH2 |
Progesterone Receptor
,
PPAR
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U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion. |
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T62924 |
Ifetroban sodium
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|
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Ifetroban (BMS-180291) sodium is an orally active thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor antagonist. It is used to study myocardial ischaemia, stroke, hypertension, thrombosis and cardiomyopathy. |
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TMIH-0281 |
Indobufen-d5
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Indobufen-d5 is a deuterated compound of Indobufen. Indobufen has a CAS number of 63610-08-2. Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobu... |
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T36550 |
CAY10535
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TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucida... |
