|
T12073 |
ML-109
|
|
TSH Receptor
|
|
ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM) |
|
T12192 |
NCGC00229600
|
|
Others
,
TSH Receptor
|
|
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies. |
|
T5360 |
Eprotirome
|
KB2115 |
Thyroid hormone receptor(THR)
|
|
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist. |
|
T40548 |
NH-3
|
|
Thyroid hormone receptor(THR)
|
|
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the... |
|
T1604 |
Tiratricol
|
3,3',5-Triiodothyroacetic acid |
Thyroid hormone receptor(THR)
|
|
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of A... |
|
T5383 |
D3-βArr
|
NCGC00379308 |
TSH Receptor
|
|
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation. |
|
T3595 |
Resmetirom
|
VIA-3196,MGL3196 |
Thyroid hormone receptor(THR)
|
|
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist. |
|
T13072 |
Taltirelin acetate
|
TA-0910 acetate |
Thyroid hormone receptor(THR)
|
|
Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release)). |
|
T13492 |
3,5-Diiodothyropropionic acid
|
C082182,Ditpa cpd |
Thyroid hormone receptor(THR)
|
|
3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40/M and 4.06/M for TRα1 and TRβ1). |
|
T5313 |
Sobetirome
|
IACS-010759,QRX-431 |
Thyroid hormone receptor(THR)
|
|
Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM). |
|
T1669 |
Liothyronine sodium
|
3,3',5-Triiodo-L-thyronine sodium,Triostat,T3 Sodium salt,Sodium L-3,3',5-triiodothyronine,Cytomel |
Thyroid hormone receptor(THR)
|
|
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium (3,3',5-Triiodo-L-thyronine s... |
|
TP1022 |
Protirelin Acetate
|
TSH-RF Acetate,TRH Acetate,TRF Acetate |
Thyroid hormone receptor(THR)
,
Endogenous Metabolite
|
|
Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary. |
|
T7578 |
REVERSE T3
|
3,3',5'-triiodo-L-thyronine |
Thyroid hormone receptor(THR)
|
|
Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes. |
|
T22355 |
L-Thyroxine sodium
|
LT4 sodium,Levothyroxine sodium,L-T4 sodium |
Thyroid hormone receptor(THR)
|
|
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta. |
|
T7590 |
Taltirelin
|
TA-0910 |
Thyroid hormone receptor(THR)
|
|
Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1]. |
|
T15699 |
L-Thyroxine sodium salt pentahydrate
|
Sodium levothyroxine pentahydrate,Levothyroxine |
Thyroid hormone receptor(THR)
|
|
L-Thyroxine sodium salt pentahydrate, also known as Levothyroxine, is a synthetic hormone utilized in the study of hypothyroidism. It is biologically activated into Triiodothyronine (T3) from its original form, L-Thyroxi... |
|
T23673 |
AH-3960
|
AH3960 |
Thyroid hormone receptor(THR)
|
|
AH-3960 is an thyroid hormone receptor-1 (PTHR1) agonist. |
|
T8672 |
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE
|
BisOPP-A |
Thyroid hormone receptor(THR)
|
|
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE is targets the thyroid stimulating hormone receptor (human) |
|
T16756 |
Risarestat
|
CT 112 |
Reductase
|
|
Risarestat (CT-112) is a potent aldose reductase inhibitor and thyroid hormone receptor (TR) antagonist for the treatment of hypoglycemia. |
|
T27714 |
KB-141
|
|
|
|
KB-141 is an agonist of thyroid hormone receptor. |
|
T79089 |
THR-β modulator-1
|
|
|
|
THR-β Modulator-1 (Compound 1a) is a potent modulator of the thyroid hormone receptor β, utilized in the study of thyroid hormone receptor-associated disorders [1]. |
|
T11376 |
GC 14
|
|
Others
|
|
|
|
T16403 |
Org41841
|
Org-41841 |
TSH Receptor
|
|
Org41841 is an agonist of luteinising hormone/chorionic gonadotropin receptor and thyroid stimulating hormone receptor (EC50s: 0.2 and 7.7 μM, respectively) and can be used to study hyperthyroidism. |
|
T29011 |
Triiodothyronine Sulfate
|
|
Thyroid hormone receptor(THR)
,
Endogenous Metabolite
|
|
Triiodothyronine Sulfate is a prodrug to the Conventional Hormone Therapy of Hypothyroidism. Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of... |
|
T11954 |
MB-07344
|
|
Others
|
|
MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. |
|
T63876 |
TRβ agonist 1
|
|
|
|
TRβ Agonist 1, a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, demonstrates an EC50 value of 21 nM. It is useful in the research of dyslipidemia, nonalcoholic steatohepatitis (NASH), and resi... |
|
T13435 |
TR antagonist 1
|
|
Thyroid hormone receptor(THR)
|
|
TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities. |
|
T11954L |
MB-07344 sodium
|
|
Others
|
|
MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys. MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. |
|
TP1677 |
Calcitonin (8-32), salmon
|
|
|
|
Calcitonin (8-32), salmon is a highly selective amylin receptor antagonist.Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafol... |
|
T35839 |
3-Iodothyronamine (hydrochloride)
|
|
|
|
3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. It activates the G protein-coupled receptor known as trace amine-associated receptor 1 at nanomolar concentrations whereupon... |
|
T62570 |
THR-β agonist 1
|
|
|
|
THRβ Agonist 1 is a potent and selective THRβ agonist. THRβ Agonist 1 has the potential to be used in studies of thyroid hormone receptor related disorders. |
|
T74785 |
THR-β agonist 6
|
|
|
|
THR-β Agonist 6, a selective and orally active compound targeting the thyroid hormone receptor β (THR-β), demonstrates specificity with EC50 values of 0.03 μM for THR-β and 0.22 μM for THR-α. This compound boasts a remar... |
|
T35712 |
Debutyldronedarone hydrochloride
|
SR35021 hydrochloride |
|
|
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbut... |
