|
T3042 |
JAK2 Inhibitor V
|
JAK2 Inhibitor V Z3,Z3 |
JAK
|
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JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner. |
|
T4443 |
AZ32
|
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ATM/ATR
|
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AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. |
|
T19671 |
AZ31
|
AZ 31,AZ-31 |
ATM/ATR
|
|
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK f... |
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T5172 |
AZ304
|
|
c-Fms
,
Raf
,
p38 MAPK
,
Autophagy
|
|
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM). |
|
T77678 |
TZ3O
|
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AChR
|
|
TZ3O is an anticholinergic compound with neuroprotective activity.TZ3O ameliorates memory impairment and cognitive decay in Scopolamine-induced Alzheimer's type model in rats, and can be used in the study of Alzheimer's ... |
|
T5182 |
AMZ30
|
|
Others
|
|
AMZ30 is a selective inhibitor of PME-1 (IC50: 600 nM). It also reduces the demethylated form of PP2A in living cells. |
|
T23764 |
AZ3976
|
AZ 3976,AZ-3976 |
PAI-1
|
|
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities. |
|
TQ0012 |
AZ3451
|
|
Protease-activated Receptor
|
|
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM). |
|
T9658 |
DCZ3301
|
NPS ALX Compound 4a hydrochloride(1:1)(299433-10-6 Free base) |
Others
|
|
DCZ3301 is a novel aryl-guanidino inhibitor. |
|
T2689 |
AZ3146
|
AZ 3146 |
Kinesin
|
|
AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM. |
|
T71098 |
AZ3971
|
|
|
|
AZ3971 is a potent BACE1 inhibitor. AZ3971 blocks BACE1-mediated cleavage of APP and inhibits Aβ42 production HEK cells overexpressing the APP protein which carries the Swedish mutation (HEK.APPswe). |
|
T81725 |
Mz325
|
|
HDAC
|
|
Mz325 serves as a dual inhibitor of both HDAC and Sirt2, exhibiting an IC50 of 9.7 µM against Sirt2, which are implicated in the pathogenesis of cancer and neurodegenerative diseases [1]. |
|
T27522 |
GZ389988
|
GZ-389988,GZ 389988 |
|
|
GZ389988 is a potent Trk inhibitor. |
|
T69783 |
Z30529104
|
|
|
|
Z30529104 is a Rpn11 inhibitor. |
|
T71151 |
Z36
|
|
|
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Z36 is a novel Bcl-xL inhibitor, upregulating the expression levels of FAM134B, LC3, and Atg9, inducing autophagy along with autophagic cell death, resulting in ER stress and the unfolded protein response (UPR). |
|
T126167 |
Kudinoside LZ3
|
|
|
|
Kudinoside LZ3 is a useful organic compound for research related to life sciences. The catalog number is T126167 and the CAS number is 1239453-03-2. |
|
T62511 |
AZ3391
|
|
|
|
AZ3391 is a quinoxaline derivative that is a potent inhibitor of PARP. AZ3391 has potential for the study of diseases and conditions occurring in central nervous system tissues (e.g., brain and spinal cord). |
