|
T8425 |
Linoleoyl Ethanolamide
|
|
TRP/TRPV Channel
|
|
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner. |
|
T15802 |
LY2183240
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|
FAAH
,
Autophagy
|
|
LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM). |
|
T5357 |
ARN272
|
ARN 272 |
FAAH
|
|
ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor (IC50: 1.8 μM). |
|
T12302 |
OMDM-1
|
(Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide |
Endogenous Metabolite
|
|
OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM. |
|
T12307 |
OMDM-6
|
|
Cannabinoid Receptor
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM. |
|
T8646 |
URB937
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|
FAAH
|
|
URB937 is an inhibitor of FAAH and increases anandamide levels(IC50 : 26.8 nM). |
|
T15948 |
MAFP
|
Methyl Arachidonyl Fluorophosphonate |
Phospholipase
|
|
MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2. |
|
T12306 |
OMDM-5
|
|
Cannabinoid Receptor
,
Endogenous Metabolite
,
TRP/TRPV Channel
|
|
OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM). |
|
T3354 |
BIA 10-2474
|
BIA10-2474 |
FAAH
,
Autophagy
|
|
BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest o... |
|
T12305 |
OMDM-4
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|
Others
|
|
OMDM-4 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor(Ki of 17.7 μM). |
|
T12303 |
OMDM-2
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|
Others
|
|
OMDM-2 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor(Ki of 3.0 μM). |
|
T12304 |
OMDM-3
|
|
Others
|
|
OMDM-3 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor(Ki of 16.6 μM). |
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T23503 |
VDM 11
|
|
Others
|
|
anandamide transport inhibitor |
|
T23006 |
MM-22
|
|
Others
|
|
biotinylated anandamide analog acts as a probe for visualizing the accumulation and intracellular trafficking of anandamide |
|
T23100 |
O-2093
|
|
Others
|
|
anandamide uptake inhibitor |
|
T38389 |
Prostaglandin D2 Ethanolamide
|
Prostaglandin D2 Ethanolamide |
|
|
Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The ... |
|
T69577 |
LEI-301
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|
|
|
LEI-301 is a novel potent inhibitor for the PLAAT family members, reducing the NAE levels, including anandamide, in cells overexpressing PLAAT2 or PLAAT5. |
|
T27681 |
JNJ-40355003
|
JNJ40355003 |
|
|
JNJ-40355003, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, elevates the plasma levels of three fatty acid amides: anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide, in the rat, dog, and c... |
|
T37785 |
1-Palmitoyl-2-linoleoyl PE
|
|
|
|
Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in... |
|
T39281 |
AM404
|
|
|
|
AM404 is a chemical compound that functions as an inhibitor of endocannabinoid reuptake. It effectively blocks the transport of anandamide, with IC50 values measured in the low micromolar range. Moreover, AM404 exhibits ... |
|
T37530 |
Glycerophospho-N-Arachidonoyl Ethanolamine
|
|
|
|
N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. The different types of NAE can be derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1... |
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T37217 |
N-Decanoyl p-Nitroaniline
|
|
|
|
N-Decanoyl p-nitroaniline (DepNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. FAAH is a relatively unselective enzyme in that it accepts a var... |
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T37684 |
CAY10412
|
CAY10412 |
|
|
Anandamide (arachidonoyl ethanolamide; AEA) is an endogenous lipid with cannabinergic activity; along with 2-arachidonoyl glycerol, it forms part of the endocannabinoid system. AEA undergoes reuptake into neurons by a fa... |
