|
T4328 |
OSS_128167
|
SIRT6-IN-1 |
HBV
,
Sirtuin
|
|
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). |
|
T6439 |
Cetylpyridinium Chloride
|
Cetamium,Pristacin,Hexadecylpyridinium Chloride |
Others
,
HBV
,
Antibacterial
|
|
Cetylpyridinium Chloride (Hexadecylpyridinium Chloride) is a cationic quaternary ammonium compound used as oropharyngeal antiseptic. |
|
T11550 |
Helioxanthin derivative 5-4-2
|
Helioxanthin 5-4-2 |
HBV
|
|
Helioxanthin derivative 5-4-2 （Helioxanthin 5-4-2） is an analogue of helioxanthin that shows anti-HBV activity in vitro and can be used to study HBV. |
|
T16366 |
NVR 3-778
|
|
HBV
|
|
NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM belonging to the SBA class It has anti-HBV activity. |
|
T8471 |
Vonafexor
|
EYP001,PLX007,pxl007 |
FXR
,
HBV
|
|
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects |
|
T4121 |
Bicyclol
|
SY801 |
HBV
,
Autophagy
|
|
Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibi... |
|
T11669 |
IR415
|
|
HBV
|
|
|
|
T76937 |
Burfiralimab
|
hzVSF-v13 |
HBV
|
|
Burfiralimab (hzVSF-v13) is a monoclonal immunoglobulin (IgG4) directed against waveform proteins that
has anti-HBV effects and can be used to study rheumatoid arthritis, |
|
T67797 |
DDG-39
|
1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine |
Antiviral
,
HBV
,
HIV Protease
|
|
DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine) possesses antiviral activity with potent and selective anti-HIV-1 and HBV activity in cell culture. The average antiviral IC50 is 0.61 μM. |
|
T39043 |
Tenofovir amibufenamide
|
HS-10234 |
HBV
|
|
Tenofovir amibufenamide (HS-10234) (HS-10234) is a Tenofovir prodrug, an antiviral compound with oral activity. Tenofovir amibufenamide inhibits hepatitis B virus (HBV) and can be used in chronic hepatitis B (CHB) studie... |
|
T26771 |
Bentysrepinine
|
Y 101,Y101,Y-101 |
|
|
Bentysrepinine, a novel anti-HBV agent, inhibits DNA-HBV and cccDNA activities for the treatment of hepatitis B virus (HBV)-infected hepatitis. |
|
T39744 |
Firzacorvir
|
|
|
|
Firzacorvir is a cyclic sulfamide compound that acts as an HBV core protein modulator and exhibits potent anti-HBV activity, with an EC50 value of < 1 μΜ. |
|
T61115 |
HBV-IN-25
|
|
|
|
HBV-IN-25 is a novel chemical compound that acts as a potent HBV cccDNA reducer when administered orally. It exhibits significant anti-HBeAg potency and anti-HBV activity, with IC50 values of 0.58 μM and 1.15 μM, respect... |
|
T36747 |
HBV-IN-4
|
|
|
|
HBV-IN-4, a derivative of phthalazinone, functions as a potent, orally active inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. It effectively induces the formation of genome-free capsids, demonstratin... |
|
T73147 |
Neracorvir
|
|
|
|
Neracorvir is a potent antiviral agent. Neracorvir exhibits anti- HBV activity . |
|
T78783 |
HBV-IN-35
|
|
HBV
|
|
Compound HBV-IN-35 (Compound 88) serves as an HBV inhibitor and exhibits anti-HBV activity in both mouse and human hepatocytes with EC50 values of 100 nM and 400 nM, respectively [1]. |
|
T29198 |
Z060228
|
Z 060228,Z-060228 |
|
|
Z060228 is an potent anti-HBV inhibitor. The HBV DNA replication was effectively inhibited by Z060228 in the supernatants of the HepG2.2.15 cells. Z060228 exhibited effects on the self-assembly of Cp149. SEC data reveale... |
|
T62704 |
HBV-IN-23
|
|
|
|
HBV-IN-23 (Compound 5k) is an inhibitor of HBV DNA replication (IC50: 0.58 μM). HBV-IN-23 inhibits drug-sensitive and drug-resistant strains. HBV-IN-23 induces apoptosis in HepG2 cells and exhibits anti-hepatocellular ca... |
|
T73282 |
HBV-IN-31
|
|
|
|
HBV-IN-31, a potent inhibitor of covalently closed circular DNA (cccDNA), demonstrates significant anti-HBV activity by inhibiting cell growth and exhibiting an IC50 value of 0.13 µM for HBsAg. |
|
T73283 |
HBV-IN-32
|
|
|
|
HBV-IN-32, a potent inhibitor of covalently closed circular DNA (cccDNA), exhibits significant anti-Hepatitis B Virus (HBV) activity by achieving an IC50 of 0.14 µM against HBsAg. Additionally, it impedes cell growth. |
|
T62626 |
HBV-IN-12
|
|
|
|
HBV-IN-12 is a potent inhibitor of hepatitis B surface antigen (HBsAg) (0.001 μM < EC50 ≤ 0.05 μM). HBV-IN-12 is anti-HBV DNA (0.001 μM < EC50 ≤ 0.02 μM). |
|
T11549 |
Helioxanthin 8-1
|
Helioxanthin analogue 8-1 |
Others
|
|
Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM. |
|
T79469 |
HBV-IN-34
|
|
HBV
|
|
HBV-IN-34 (compound 17i) is a potent inhibitor of HBsAg production, demonstrating remarkable in vitro anti-HBV efficacy with EC50 values of 0.018 μM for HBV DNA and 0.044 μM for HBsAg [1]. |
|
T78812 |
HBV-IN-36
|
|
HBV
|
|
HBV-IN-36 (also known as compound 42) is a hepatitis B virus (HBV) inhibitor with an IC50 of 2 μM, exhibiting anti-HBV activity characterized by an EC50 of 0.58 μM [1]. |
|
T72324 |
Lagociclovir valactate
|
|
|
|
Lagociclovir valactate is a prodrug of Lagociclovir . Lagociclovir valactate is an orally active anti- HBV agent [1] . |
|
T77001 |
Exbivirumab
|
|
|
|
Exbivirumab is an anti-hepatitis B virus monoclonal antibody (anti-HBV mAb) that amplifies the antiviral effects of hepatitis B immunoglobulin (HBIG) [1]. |
|
T60285 |
L-2'-Fd4C
|
|
|
|
L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1]. |
|
T78756 |
Yhhu6669
|
|
HBV
|
|
Yhhu6669 is an anti-HBV agent that suppresses viral DNA and replication by promoting DNA-free capsid assembly, effectively reducing HBV DNA and HBcAg levels in AAV/HBV-infected mice and demonstrating favorable pharmacoki... |
|
T72796 |
Junceellolide C
|
|
|
|
Junceellolide C, a potent anti-HBV agent, acts as a transcription inhibitor of cccDNA, effectively inhibiting HBV DNA replication and significantly reducing supernatant HBV RNA levels in HepAD38 cells, with EC50 values o... |
|
T76321 |
Brain Derived Basic Fibroblast Growth Factor (1-24)
|
|
|
|
Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24), a synthetic peptide, exhibits anti-bacterial and anti-HBV properties, finding application in infectious and immune disease research [1]. |
|
T60374 |
L-Fd4A
|
|
|
|
L-Fd4A (compound 36) is an adenine derivative that has anti-human immunodeficiency virus (HIV) (EC 50 =1.5 μM) and anti- hepatitis B virus (HBV) ( EC 50 =1.7 μM) activity. L-Fd4A has low cytotoxicity [1]. |
|
T37065 |
6-Chloro-2-fluoropurine
|
|
|
|
6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the ... |
