|
T36674 |
DMU-212
|
|
Apoptosis
,
ERK
|
|
DMU-212 is a methylated derivative of Resveratrol , with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2... |
|
T1753 |
D-64131
|
|
Microtubule Associated
|
|
D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM. |
|
T22661 |
CHM-1
|
|
Apoptosis
,
Others
,
Microtubule Associated
|
|
CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo. |
|
T10460 |
Batabulin
|
T138067 |
Apoptosis
,
Microtubule Associated
|
|
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce... |
|
T20681 |
Estramustine
|
NSC-89201,NSC 89201,LEO 275,LEO275,NSC89201,LEO-275 |
Microtubule Associated
|
|
Estramustine (LEO-275) is a nitrogen mustard linked to estradiol, usually as phosphate. Estramustine has been used to treat prostatic neoplasms; also has radiation protective properties. Estramustine is selectively taken... |
|
T4451 |
Estramustine phosphate sodium
|
Ro 21-8837/001,Estramustine phosphate disodium |
Apoptosis
,
Microtubule Associated
|
|
Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle. |
|
T26046 |
Razoxane
|
|
Topoisomerase
|
|
Razoxane is used as an antimitotic agent with immunosuppressive properties. |
|
T3256 |
MMAF
|
MonoMethyl auristatin F |
Others
,
Microtubule Associated
|
|
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin. |
|
T0651 |
N-Phenylbenzylamine
|
Benzylaniline,Benzenemethanamine |
Microtubule Associated
|
|
A series of N-Phenylbenzylamine (Benzenemethanamine) as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization |
|
T6897 |
Monomethyl auristatin E
|
Vedotin,MMAE |
Apoptosis
,
Microtubule Associated
|
|
Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity. |
|
T15576 |
Indibulin
|
ZIO 301,D 24851 |
Apoptosis
,
Microtubule Associated
|
|
Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu... |
|
T3124 |
Carbendazim
|
Bavistin,Carbendazole,Mercarzole |
Antifungal
|
|
Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec... |
|
T34787 |
TAS-119
|
TAS119,TAS2104,TAS 2104,TAS-2104,TAS 119 |
Aurora Kinase
|
|
|
|
T25290 |
DAT1
|
DAT-1,DAT 1 |
|
|
DAT1 is an antimitotic and antiangiogenic that acts by binding to the colchicine binding site of tubulin. |
|
T69245 |
Amikhelline
|
|
|
|
Amikhelline is an antimitotic drug. It acts as a DNA intercalator and inhibits DNA polymerase. |
|
T26391 |
5HPP-33
|
5HPP33 |
|
|
5HPP-33 is an microtubule-stabilizer with the properties of antiproliferative and antimitotic. |
|
T12141 |
N-Boc-Val-Dil-Dap-Doe
|
|
Others
|
|
N-Boc-Val-Dil-Dap-Doe is used to synthesize Dolastatin 10 , which is a potent antimitotic peptide, inhibits tubulin polymerization. |
|
T71924 |
AVE-8063
|
|
|
|
AVE-8063 is an antimitotic agent or microtubule inhibitor with potential anticancer activity. |
|
T70958 |
Dov-Val-Dil-OH TFA
|
|
|
|
Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the po... |
|
T16997 |
Tasidotin hydrochloride
|
ILX651 |
Microtubule Associated
|
|
Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15. Tasidotin hydrochloride is an inhibitor of microtubule assembly and microtubule dynamics. |
|
T68232 |
Epofolate
|
|
|
|
Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated th... |
|
T69283 |
Amikhellin HCl
|
|
|
|
Amikhellin HCl, an antimitotic drug, is a synthetic water-soluble derivative of khellin, an alkaloid extracted from seeds of Ammi Visnaga. Amikhellin has been used so far mostly as a vasodiator. Amikhellin binds to doubl... |
|
T15158 |
Dolastatin 15
|
DLS 15 |
Others
|
|
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces c... |
|
T64273 |
Nampt-IN-10 TFA
|
|
|
|
Nampt-IN-10 TFA (compound 4) is a phosphoribosyltransferase (NAMPT) inhibitor with cellular efficacy against A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM). The Nampt-IN-10 TFA can be used as a non-antimitotic payload for A... |
|
T77874 |
Maytansinoid B
|
|
|
|
Maytansinoid B, an ADC cytotoxin, conjugates with antibodies to create antibody-drug conjugates (ADCs). This antimitotic agent binds to tubulin, inhibiting microtubule assembly, and induces G2/M arrest in the cell cycle,... |
|
T72552 |
Antitumor agent-88
|
|
|
|
Antitumor agent-88, a competitive inhibitor of CYP1A1 (K i: 1.4 μM), demonstrates significant antimitotic activity by arresting cells in the G2/M phase and disrupting the microtubule network and cytoskeleton in CYP1A1-ex... |
|
T69003 |
E7974
|
|
|
|
E7974 is an analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inh... |
|
T68363 |
OUN10989
|
|
|
|
OUN10989, an analogue compound of LP-261, is a Potent Antimitotic Agent. OUN10989 exhibited potent inhibition of mitosis at the G2/M stage. OUN10989 was first reported in J. Med. Chem 54(1), 179-200; 2011 (compound 7). T... |
|
T22631 |
Dolastatin 10 trifluoroacetate
|
|
Others
|
|
Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerizati... |
|
T74562 |
Nampt-IN-10 trihydrochloride
|
|
|
|
Nampt-IN-10 trihydrochloride (Compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor exhibiting cellular potency against A2780 and CORL23 cell lines, with IC50 values of 5 nM and 19 nM, respectively. I... |
|
T79708 |
SSE1806
|
|
|
|
SSE1806, a podophyllotoxin derivative (a natural antimitotic agent), functions as a microtubule/tubulin inhibitor, exhibiting potent anticancer and antiproliferative properties. It demonstrates a GI50 for inhibiting canc... |
