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T60073 |
Antimycobacterial agent-4
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4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide |
Antibacterial
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Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis. |
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T63420 |
Antimycobacterial agent-2
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Antimycobacterial agent-2 is an effective anti-mycobacterial agent with a MIC99 of 0.8 μM against Mycobacterium tuberculosis (M.tb) H37Rv. Antimycobacterial agent-2 is cytotoxic, acting on CHO cells (IC50: 48.1 μM). |
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T63865 |
Antimycobacterial agent-3
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Antimycobacterial agent-3 is an antimycobacterial agent with low cytotoxicity. antimycobacterial agent-3 is effective against sensitive MTB strain H37Rv and resistant clinical isolates (MIC < 0.029-0.110 μ M). |
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T61853 |
Antimycobacterial agent-1
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Antimycobacterial agent-1 (compound 33) demonstrates potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra, with a minimal inhibitory concentration (MIC) value of 1 μg/ml. Notably, antimycobacterial ... |
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T79281 |
Antimycobacterial agent-6
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Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting the Mtb DprE1-C387S mutant. It displays minimal inhibitory ... |
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T0891 |
Dapsone
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DDS,4,4‘-Sulfonyldianiline,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone |
Reactive Oxygen Species
,
Antibacterial
,
Antibiotic
,
Parasite
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Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. |
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T6425 |
BTZ043 Racemate
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BTZ044,BTZ10526038,Benzothiazinone 10526038 |
Antibacterial
,
DprE1
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BTZ043 Racemate (Benzothiazinone 10526038) is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor, used as a new antimycobacterial agent. |
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T7342 |
BM212
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Antibacterial
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BM212 is an antimycobacterial compound.It inhibits the growth of laboratory and clinical isolate M. tuberculosis strains. |
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T19794 |
Temafloxacin
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Omniflox |
Antibiotic
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Temafloxacin (Omniflox) is an antibiotic and antimycobacterial agent. It used to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. |
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T1501 |
Rifabutin
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LM-427,Ansamycin |
HSP
,
DNA/RNA Synthesis
,
Antibacterial
,
Antibiotic
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Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin... |
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T11594 |
I2906
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Others
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I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis. |
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T25565 |
Kahalalide A
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Kahalalide A has antimycobacterial activity isolated from the mollusk Elysia rufescens. |
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T25462 |
Griselimycin
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RP-11072-B,RP11072-B,RP 11072-B,Grisellimycin B |
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Griselimycin is a natural antimycobacterial product that is currently being pursued as a therapy for tuberculosis. |
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T61192 |
CBR-6672
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CBR-6672, a type II NADH dehydrogenase inhibitor, demonstrates potent antimycobacterial activity against mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 0.14 μM [1]. |
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T62086 |
Tuberculosis inhibitor 5
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Tuberculosis inhibitor 5 (Compound 11i) is a potent anti-tuberculosis agent with no apparent cytotoxicity. tuberculosis inhibitor 5 is an antimycobacterial biphenyl analogue. |
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T35872 |
BRD-8000.3
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BRD-8000.3 is a narrow-spectrum, bactericidal antimycobacterial agent known for its specific inhibition of EfpA. It exhibits potent activity against wild-type strains and proves to be a valuable tool in tuberculosis rese... |
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T80926 |
Tuberculosis inhibitor 11
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Compound 14, also known as Tuberculosis Inhibitor 11, enhances the antimycobacterial efficacy of antitubercular agent [1]. |
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T38355 |
Lariatin A
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Lariatin A is an antimycobacterial lasso peptide originally isolated from R. jostii. It is active against M. tuberculosis and M. smegmatis in vitro (MICs = 0.39 and 0.1 μg/ml, respectively). Lariatin A increases survival... |
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T7062 |
Ethambutol
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Ethambutol is a bacteriostatic antimycobacterial agent obstructed the formation of cell wall by inhibiting arabinosyl transferases. |
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T61984 |
MtMetAP1-IN-1
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MtMetAP1-IN-1 is an inhibitor of methionine aminopeptidase 1 ( MetAP1 ). MtMetAP1-IN-1 shows antimycobacterial activity. |
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T80927 |
Tuberculosis inhibitor 10
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Tuberculosis Inhibitor 10 moderately inhibits the enzyme MSMEG_6649 and potentiates the antimycobacterial activity of PAS [1]. |
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T79029 |
IpOHA
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IpOHA is a potent inhibitor of plant KARI and functions as an antimycobacterial agent, demonstrating a K_i value of 97.7 nM against Mycobacterium tuberculosis (Mt) [1]. |
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T60468 |
Anti-infective agent 3
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Anti-infective agent 3 is an antiprotozoal and antimycobacterial agent. Anti-infective agent 3 (compound 3l) exhibits antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC 50 values of 0.47 and ... |
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T37539 |
Amycolatopsin A
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Amycolatopsin A is a macrolide polyketide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.1It is active againstM. bovisandM. tuberculosis(IC50s = 0.4 and 4.4 μM, respectively) bu... |
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T62087 |
Tuberculosis inhibitor 4
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Tuberculosis inhibitor 4 (compound 16) is a spirothiazolidinone based on mandelic acid that exhibits potent antimycobacterial action. The inhibitor inhibited 98% of Mycobacterium tuberculosis strain H37Rv at concentratio... |
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T60465 |
Anti-infective agent 2
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Anti-infective agent 2 (compound 3k) is an antiprotozoal and antimycobacterial agent. Anti-infective agent 2 exhibits antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC 50 values of 0.07 and ... |
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T60315 |
Anti-infective agent 1
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Anti-infective agent 1 (compound 3a) serves as a potent, selective antiprotozoal and antimycobacterial compound. It showcases antiparasitic efficacy against P. falciparum and T. brucei rhodesiense, demonstrating IC50 val... |
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T60716 |
Antitubercular agent-28
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Antitubercular agent-28 (compound 2) has antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 is a potent antitubercular agent with an MIC value of 4.5 μM, an IC ... |
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T72262 |
Antituberculosis agent-6
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Antituberculosis agent-6 is a potent antimycobacterial and antifungal compound with significant activity against M. tuberculosis (MIC of 3.49 μM) and A. niger (MIC of 62.50 μM), respectively. It also demonstrates high ga... |
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T37541 |
Amycolatopsin C
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Amycolatopsin C is a polyketide macrolide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.1It is active againstM. bovisandM. tuberculosis(IC50s = 2.7 and 5.7 μM, respectively) bu... |
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T83222 |
AB131
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AB131, an inhibitor of MSMEG 6649 and Rv2172c (KD values of 0.16 and 0.02 μM, respectively), enhances the antimycobacterial efficacy of the antitubercular agent [1]. |
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T63286 |
Antituberculosis agent-3
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Antituberculosis agent-3 is an antituberculosis agent with antimycobacterial activity and inhibited the growth of Mycobacterium tuberculosis strain H37Rv with a MIC value of 12.5 μg/mL. |
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T37070 |
Pyridomycin
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Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (A... |
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T78918 |
Antitubercular agent-37
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Antitubercular Agent-37 exhibits antimycobacterial properties and functions as an antibacterial agent with an MIC (minimum inhibitory concentration) value of 0.16 μg/mL, making it suitable for tuberculosis research [1]. |
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T61665 |
Antibacterial agent 118
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Antibacterial agent 118 (also known as compound 20) is a potent antimycobacterial compound with activity against various mycobacterial strains, including Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv, and M. avium. The mi... |
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T78714 |
PptT-IN-4
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Calcium Channel
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PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM. It also demonstrates antimycobacterial activity against Mtb H37Rv, with a MIC of 42 μM, and inhibits hERG, hCav1.2, and hNav1.5 channels with IC5... |
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T79440 |
DprE1-IN-5
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DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates antimycobacterial efficacy against drug-resistant strains. Additionally, it ... |
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T61142 |
Antitubercular agent-17
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Antitubercular agent-17 (Compound 8a) is an efficacious antitubercular agent, demonstrating Minimum Inhibitory Concentration (MIC) values of 2 μg/ml against M. tuberculosis H37Rv, Spec. 192, and Spec 210, and 128 μg/ml a... |
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T78746 |
Mtb-IN-3
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Mtb-IN-3 (compound 10c), a selective and potent Mycobacterium tuberculosis (Mtb) inhibitor, exhibits strong antimycobacterial activity in vitro without inducing cytotoxic effects and inhibits colony formation in the sple... |
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T79442 |
DprE1-IN-7
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DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM against the Mtb H37Rv strain. It exhibits antimycobacterial effect... |
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T61141 |
Antitubercular agent-27
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Antitubercular agent-27 (compound 1) exhibits potent antitubercular properties, demonstrated by an IC50 of 3.2 μM, an MIC of 7.8 μM, and an IC90 of 7.0 μM. It effectively targets resistant Mycobacterium tuberculosis H37R... |
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T61143 |
Antitubercular agent-18
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Antitubercular agent-18 (Compound 9a) is an antitubercular agent that exhibits highly selective antimycobacterial effects, with minimum inhibitory concentration (MIC) values of 2 μg/ml against M. tuberculosis H37Rv, Spec... |
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T75019 |
Antituberculosis agent-7
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Antituberculosis agent-7, an oxetanyl-quinoline derivative, exhibits potent antibacterial activity against P. mirabilis, with a minimum inhibitory concentration (MIC) of 31.25 μM, and antifungal efficacy against A. niger... |
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T78883 |
DprE1-IN-9
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DprE1-IN-9 (compound B18) is an efficient reversible inhibitor of DprE1, interacting with the enzyme's receptor cavity. It exhibits potent antimycobacterial properties, demonstrating activity against both non-pathogenic ... |
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T38073 |
Thiocarlide
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Isoxyl |
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Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant stra... |
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T35706 |
25-Desacetyl Rifampicin
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25-Desacetyl rifampicin is a major active metabolite of the rifamycin antibiotic rifampicin .125-Desacetyl rifampicin is active againstM. smegmatis(MIC99= 2.66 μM).
1.Kigondu, E.M., Njoroge, M., Singh, K., et al.Synthesi... |
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T60560 |
Anti-inflammatory agent 15
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Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial agent that can be used in the research of tuberculosis (TB). Anti-inflammatory agent 15 inhibits the growth of Mtb H37Rv and M299 with MIC50 of 2.3 a... |
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T60570 |
Anti-inflammatory agent 11
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Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial agent that can be used in the research of tuberculosis(TB). Anti-inflammatory agent 11 inhibits the growth of Mtb H37Rv and M299 with MIC 50 of 1.3 a... |
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T37540 |
Amycolatopsin B
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Amycolatopsin B is a bacterial metabolite originally isolated fromAmycolatopsisthat has anticancer activity.1It is cytotoxic to NCI H460 lung and SW620 colon cancer cells (IC50s = 0.28 and 0.14 μM, respectively).
1.Khali... |
