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T28073 |
MLS1547
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MLS000051547,MLS 1547,MLS-1547 |
Dopamine Receptor
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MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assa... |
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T23002 |
ML-335
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Opioid Receptor
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ML-335 is a μ-δ isomer-targeted agonist, a μOR-δOR-biased ligand that can serve as a scaffold for the development of unique types of (isomer-biased) drugs.ML-335 is a MOR (μ-opioid receptor)/DOR (δ-opioid receptor) heter... |
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T9596 |
AP1189 acetate
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Melanocortin Receptor
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AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors. |
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T7281 |
F-15599
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5-HT Receptor
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F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM). |
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T40508L |
TRV120056 acetate
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TRV120056 acetate (40678-47-5 Free base) |
Others
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TRV120056 acetate is a Gq-biased agonist with 10-fold greater molecular efficiency on AT1R-Gq fusion proteins than AT1R-βarr2 fusion proteins. |
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TP2158L1 |
TRV-120027 acetate (1234510-46-3 free base)
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RAAS
,
Arrestin
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TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling. |
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T16321 |
NI-42
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Epigenetic Reader Domain
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NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent sele... |
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TP2158 |
TRV-120027 TFA
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TRV-120027 TFA (1234510-46-3 free base) |
RAAS
,
Arrestin
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TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling. |
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T71946 |
ID110460003
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ID110460003 is a novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist. |
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T29064 |
UNC9975
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UNC-9975 |
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UNC9975 is an analog of aripiprazole and a β-arrestin-biased D2R agonist. |
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T71438 |
ID110460001
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ID110460001 is a novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist. |
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T71985 |
ID110460002
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ID110460002 is a novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist. |
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T40220 |
TRV055
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TRV055 |
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TRV055 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling. TRV055 can be used to develop the Gq-biased AT1R agonists. |
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T70040 |
BRD5814
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BRD5814 is a highly brain penetrant β-arrestin biased D2R antagonist. |
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T29061 |
UNC0006
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UNC 0006,UNC-0006 |
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UNC0006 is a β-arrestin-biased dopamine D2 ligand. |
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T69844 |
NLX-219
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NLX-219 is a selective 5-HT1A receptor-biased agonists. |
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T70765 |
TRV0109101
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TRV0109101 is a G protein-biased agonist of the µ-opioid receptor. |
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T40920 |
TRV056
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TRV056 |
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TRV056 is a Gq-biased agonist of the angiotensin II type 1 receptor (AT1R), demonstrating efficacy in stimulating Gq-mediated cellular signaling. It can serve as a foundation for the development of Gq-biased AT1R agonist... |
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T29066 |
UNC9995
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UNC-9995,UNC 9995 |
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UNC9995 is a β-Arrestin-Biased Dopamine D2 Receptor agonist (β-Arrestin, EC50 = 120 nM; Emax = 88%). |
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T29065 |
UNC9994
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UNC-9994,UNC 9994 |
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UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities. |
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TQ0075 |
ML314
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Neurotensin Receptor
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ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35. |
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T76196 |
TRV055 hydrochloride
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TRV055 hydrochloride, a Gq-biased ligand and G-protein-biased agonist of the angiotensin II receptor type 1 (AT1R), effectively stimulates cellular Gq-mediated signaling [1]. |
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T37622 |
F13714 fumarate
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F13714 fumarate |
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F13714 fumarate, a selective biased agonist of the 5-HT1A receptor, exhibits antidepressant-like effects upon single administration in the mouse model of chronic mild stress[1]. |
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T39870 |
5-HT7R antagonist 1 free base
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5-HT7R antagonist 1 free base |
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5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM. |
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T39995 |
TRV120055
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TRV120055 |
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TRV120055, a Gq-biased agonist, demonstrates a 10-fold higher molecular efficacy when tested against the AT1R-Gq fusion protein in comparison to the AT1R-βarr2 fusion protein. |
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T40508 |
TRV120056
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TRV120056 is a Gq-biased agonist that demonstrates a molecular efficacy ten times greater at the AT1R-Gq fusion protein than at the AT1R-βarr2 fusion protein. |
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T60790 |
5-HT7R antagonist 1
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5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R. |
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TP2158L |
TRV-120027
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Others
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TRV120027 is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. |
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T36946 |
PW0464
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PW0464 |
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PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1].
PW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R... |
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T41189 |
AY 254
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AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-woun... |
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TP2000 |
MM 07
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Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in... |
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T38716 |
SAR247799
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SAR247799,S1P1 agonist 3 |
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SAR247799 (S1P1 agonist 3) is an orally-active, selective G-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (S1P1). It demonstrates EC50 values ranging from 12.6 to 493 nM in S1P1-overexpressing cells a... |
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T37907 |
DL 175
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Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bo... |
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T76224 |
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)
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Compound 40, NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal), a macrocyclic analogue of Ape13, acts as a potent APJ agonist with a Ki of 5.7 nM. It demonstrates favorable Gα12-biased signaling and possesses an enhanced in vivo half-life... |
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T80471 |
α-Conotoxin MrIC
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α-Conotoxin MrIC is a biased agonist selective for the α7 nicotinic acetylcholine receptor (nAChR), with activation contingent upon the presence of type II positive allosteric modulators, such as PNU120596. It is utilize... |
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TP1354 |
ATI-2341 TFA (1337878-62-2 free base)
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ATI-2341 TFA |
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ATI-2341 is an effective functionally selective allosteric agonist for the c-x-c chemokine receptor type 4 (CXCR4), which ACTS as a biased ligand in favor of G G G G G 1 activation instead of G G G G G 13.ATI-2341 activa... |
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T60597 |
UCSF678
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UCSF678 is a 42 nM arrestin-biased partial agonist at the 5-HT5AR with a more restricted off-target profile and decreased assay liabilities versus the single commercial antagonist SB-699551. UCSF678 is a selective probe... |
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T62853 |
UNC9994 hydrochloride
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UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist (Ki: 79 nM) that selectively activates β- arresttin recruitment and signal transduction. UNC9994 hydrochloride is a ... |
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T82233 |
HCAR2 agonist 1
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HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokin... |
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T75721 |
ATI-2341 TFA
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ATI-2341 is a potent, functionally selective allosteric agonist of the C-X-C chemokine receptor type 4 (CXCR4), acting as a biased ligand that prefers Gαi activation over Gα13. This compound activates the inhibitory hete... |
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T37199 |
Bilaid C
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Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.1It inhibits forskolin-induced cAMP accumulation by 77% in HEK293... |
