Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 15,500 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 60,500 | |||
25 mg | 在庫あり | ¥ 102,500 | |||
50 mg | 在庫あり | ¥ 148,500 | |||
100 mg | 在庫あり | ¥ 204,000 | |||
500 mg | 在庫あり | ¥ 411,000 |
説明 | 1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells. |
植物由来 |
別名 | Flavokavain B, Flavokawin B, 2'-Hydroxy-4',6'-Dimethoxychalcone |
分子量 | 284.31 |
分子式 | C17H16O4 |
CAS No. | 1775-97-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38 mg/mL(133.7 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
You can also refer to dose conversion for different animals. 詳細
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Flavokawain B 1775-97-9 Apoptosis Others Flavokavain B inhibit Flavokawin B 2'-Hydroxy-4',6'-Dimethoxychalcone Inhibitor inhibitor