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T9420 |
Prifinium bromide
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Others
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Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action. |
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T1460 |
Dicyclomine hydrochloride
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AChR
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Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence. |
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T5491 |
GSK3179106
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c-RET
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GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM |
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T13385 |
Zamifenacin fumarate
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UK-76654 fumarate |
AChR
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Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor. |
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T4691 |
Asimadoline hydrochloride
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EMD-61753 hydrochloride |
Opioid Receptor
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Asimadoline hydrochloride (EMD-61753 hydrochloride) is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline hydrochloride has also been shown to be used in the treatment of irritable bowel s... |
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T1551 |
Tegaserod maleate
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HTF-919,SDZ-HTF-919 |
5-HT Receptor
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Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... |
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T4633 |
Asimadoline
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EMD-61753 |
Opioid Receptor
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Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline... |
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T4562L |
Ramosetron hydrochloride
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YM 060,YM-060,YM060 |
5-HT Receptor
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Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea. |
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T28043L |
Minesapride
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5-HT Receptor
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Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation. |
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T11852 |
リナクロチド
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Guanylate cyclase
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Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist. |
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T22577 |
Antalarmin hydrochloride
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CRFR
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Immunology/Inflammation related
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Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel... |
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T38507 |
Renzapride
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BRL 24924 |
5-HT Receptor
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Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS). |
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T69984 |
Ticalopride
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5-HT Receptor
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Ticalopride is a 5-HT3 receptor agonist used in the treatment of digestive disorders, orofacial disorders, otorhinolaryngologic disorders, and may be used in the study of bulimia nervosa, gastroesophageal reflux, and irr... |
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T60680 |
Tegaserod
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5-HT Receptor
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Tegaserod is an orally available 5-HT4R agonist and 5-HT2B receptor antagonist with inhibitory effects on various 5-hydroxytryptamine receptors. Tegaserod has antitumor activity and is used in the treatment of irritable ... |
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T12970 |
Solabegron
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GW 427353 |
Adrenergic Receptor
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Solabegron (GW 427353) is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladd... |
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T0786 |
Clidinium bromide
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Ro 2-3773 |
AChR
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Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can... |
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T4562 |
Ramosetron
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5-HT Receptor
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Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondanse... |
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T0918 |
Trimebutine
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Mebutin |
Opioid Receptor
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Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl... |
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T30936 |
Cilansetron Hydrochloride
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KC-9946,KC9946,KC 9946 |
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Cilansetron Hydrochloride can be used for irritable Bowel Syndrome (IBS) with Diarrhea Predominance. |
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T10289 |
Alosetron ((Z)-2-butenedioate)
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GR 68755 ((Z)-2-butenedioate),GR 68755X ((Z)-2-butenedioate) |
Others
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Alosetron (GR 68755) (Z)-2-butenedioate is a Serotonin 5HT3-receptor antagonist that is used in the treatment of irritable bowel syndrome. |
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T17283 |
Zamifenacin
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UK-76654 |
Others
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Zamifenacin obviously decreases colonic motility in irritable bowel syndrome. Zamifenacin is an effective gut-selective muscarinic M3 receptor antagonist. |
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T14966 |
Cimetropium Bromide
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DA-3177 |
AChR
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T13002 |
SSR-241586
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Others
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SSR-241586 is a neurokinin receptors antagonist,and is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS). |
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T21235 |
Alosetron
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Lotronex,GR68755,GR-68755,GR 68755 |
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Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. |
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T16683 |
Pumosetrag Hydrochloride
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MKC-733,DDP-733 |
5-HT Receptor
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T38482 |
MM 419447
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MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research. |
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T35046 |
Velusetrag
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TD 5108,TD5108,TD-5108 |
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Velusetrag(TD-5108)is an effective, selective, and highly potent agonist of the 5-HT4 receptor, and being developed for the treatment of gastroparesis, chronic constipation, and irritable bowel syndrome. |
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T11852L |
Linaclotide acetate
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MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775 |
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Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation. |
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T80431 |
δ-Theraphotoxin-Hm1a toxin
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Sodium Channel
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δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications in irritable bowel syndrome research [1]. |
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T72809 |
(S)-Renzapride
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(S)-BRL 24924 |
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(S)-Renzapride ((S)-BRL 24924), an isomer of Renzapride, acts as a 5-HT4 receptor agonist with a K_i value of 115 nM and also antagonizes 5HT2b and 5HT3 receptors. It is utilized in studies focused on constipation-predom... |
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T16393 |
ONO-2952
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Others
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ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels, and enzymes. ONO-2952 is a potent and selective translocator protein 18 kDa (TSPO) antagonist (Ki: 0.33-9.30 nM for rat and human TSPO... |
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T64234 |
Alosetron (Hydrochloride(1:X))
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Alosetron (GR 68755) Hydrochloride (1:X) is a potent and highly selective 5-HT3 receptor antagonist with anti-inflammatory effects. Alosetron Hydrochloride (1:X) can be used in the study of irritable bowel syndrome (IBS)... |
