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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T21654 | 1-Oleoyl lysophosphatidic acid sodium | 1-Oleoyl lysophosphatidic acid sodium salt | LPA Receptor |
1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2 | |||
T36907 | 1-Oleoyl Lysophosphatidic Acid | Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid | |
1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through ... | |||
T33076 | Lysophosphatidic acid | ||
Lysophosphatidic acid is a bioactive chemical. | |||
T83879 | 1-Arachidoyl Lysophosphatidic Acid sodium | 1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid | |
1-Arachidoyl lysophosphatidic acid (1-arachidoyl LPA), a glycerophospholipid with arachidic acid at the sn-1 position, functions as an agonist for lysophosphatidic acid receptor 1 (LPA1). It effectively induces calcium m... | |||
T36768 | 1-Octadecyl Lysophosphatidic Acid | ||
1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses... | |||
T37283 | 1-Palmitoyl Lysophosphatidic Acid (sodium salt) | ||
1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological... | |||
T36452 | 1-Arachidonoyl Lysophosphatidic Acid (ammonium salt) | ||
1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is... | |||
T37282 | 1-Palmitoyl Lysophosphatidic Acid | Antibacterial | |
1-Palmitoyl Lysophosphatidic Acid is an analog of LPA and improves the the action of ampicillin, piperacillin, and ceftazidime on various strains of P. aeruginosa via binding both Ca2+ and Mg2+. | |||
T77789 | Oleoyl-L-alpha-lysophosphatidic acid sodium salt | LPA sodium salt | |
Oleoyl-L-alpha-lysophosphatidic acid sodium salt is an essential cell membrane biosynthetic metabolite that mediates signal transduction by interacting with G protein-coupled receptors (GPCRs) (ie, LPA receptors). It is ... | |||
T83772 | 1-Linoleoyl Lysophosphatidic Acid sodium | 1-Linoleoyl-2-hydroxy-sn-glycero-3-PA,LPA(18:2),PA(18:2(9Z,12Z)/0:0),1-Octadecadienoyl-2-hydroxy-sn-glycero-3-phosphate,18:2 Lyso PA,1-Octadecadienoyl-2-hydroxy-sn-glycero-3-PA,PA(18:2/0:0),1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphate,1-Linoleoyl LPA | |
1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This co... | |||
T22834 | H2L 5765834 | LPA Receptor , LPL Receptor | |
H2L 5765834 is a lysophosphatidic acid receptors antagonist | |||
T21694 | (R)-Lisofylline | (R)-Lisophylline | STAT |
(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM). (R)-Lisofylline interrupts IL-12 signaling-mediated STAT4 activation and can be used in studies about the treat... | |||
T11533 | Z-HA155 | CS-963 | PDE |
Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM. | |||
T2008 | LY294002 | LY 294002,NSC 697286,SF 1101 | Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy |
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ... | |||
T4079 | LY-294002 hydrochloride | SF 1101,LY 294002,NSC 697286 | PI3K |
LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation... | |||
T7393 | ONO-7300243 | LPA Receptor , LPL Receptor | |
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM). | |||
T10415 | Autotaxin-IN-3 | PDE | |
Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma. | |||
T15785 | LPA1 receptor antagonist 1 | LPA1 R antagonist 1 | LPA Receptor |
LPA1 receptor antagonist 1(LPA1 R antagonist 1) is a selective and potent lysophosphatidic acid (LPA1) receptor antagonist (IC50 : 25 nM) for the study of idiopathic pulmonary fibrosis. | |||
T7689 | Tetradecyl Phosphonate | LPA Receptor | |
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors. | |||
T10381 | AS2717638 | Others | |
AS2717638 is an orally active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50: 38 nM for hLPA5). It also significantly improves PGF2α-, PGE2-, and AMPA-induced allodynia. | |||
T3631 | PF-8380 | PDE | |
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib... | |||
T22070 | DBIBB | LPA Receptor | |
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of acute radiation syndrome caused by high intensity gamma ra... | |||
T25847 | NAEPA | ||
NAEPA, an LPA mimetic, is a selective agonist of the lysophosphatidic acid-1 (LPA1) receptor. | |||
T29109 | VPC12249 | VPC-12249,VPC 12249 | |
VPC12249, a lysophosphatidic acid receptor type 1 (LPA1) antagonist, plays a functional role in osteoclast differentiation and bone resorption activity. | |||
T63645 | ONO-9780307 | ||
ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM). | |||
T14335 | ASP6432 | LPA Receptor | |
ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively. | |||
T28300 | PAT-347 sodium | PAT-347,PAT347,PAT 347 | |
PAT-347 is a potent inhibitor of Autotaxin (ATX), a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. | |||
T73017 | ONO-0740556 | ||
ONO-0740556 is a potent agonist of the Gi-coupled human lysophosphatidic acid receptor 1 (LPA1), exhibiting an EC50 value of 0.26 nM. | |||
T69647 | UCM-05194 | ||
UCM-05194 is a potent Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1). UCM-05194 Shows Efficacy in Neuropathic Pain Amelioration. UCM-05194 stands out as the most potent and selective LPA1 receptor agonist de... | |||
T83882 | XY-4 | ||
XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively induces reporter gene expression in RAW 264.7 macrophages h... | |||
T63231 | LPA5 antagonist 1 | ||
LPA5 antagonist 1 is a selective and potent lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 32 nM. LPA5 antagonist 1 has high brain permeability and antinociceptive activity and can be used to st... | |||
T27094 | CT-2584 | CT2584 | |
CT-2584 is an angiogenesis inhibitor and lysophosphatidic acid acyltransferase inhibitor. CT-2584 inhibits phospholipid signaling. By inhibiting CTP:choline-phosphate cytidylyltransferase (CT), CT-2584 caused de novo pho... | |||
T36138 | BMP-22 | ||
BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid... | |||
T63439 | BMS-986020 sodium | ||
BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist that inhibits bile acids and phospholipid transport proteins, and inhibits BSEP (IC50: 4.8 μM), MRP4 (IC50: 6.2 μM) and MDR3 (IC50: ... | |||
T16434 | PAT-048 | PDE | |
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic ac... | |||
T70275 | PAT-347 | ||
PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signali... | |||
T37691 | Phosphatidic Acids (egg) (ammonium salt) | ||
Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis. It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple rout... | |||
T36502 | DCP-Rho1 | DCP-Rho1 | |
DCP-Rho1 is a fluorescent probe for the detection of sulfenic acid-containing proteins.1,2 It displays excitation/emission maxima of 560/581 nm, respectively, and has been used to visualize protein oxidation sites in sit... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-00463 | ENPP2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-02778 | ENPP2 Protein, Human, Recombinant (His) | Human | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPH-00846 | ABHD5 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-ly... | |||
TMPH-00556 | 1-AGPAT Protein, E. coli, Recombinant (His) | E. coli | Yeast |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor. | |||
TMPK-00027 | PLA2G1B Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Phospholipase A2 (PLA2) plays crucial roles in diverse cellular responses, including phospholipid digestion and metabolism, host defense and signal transduction. PLA2 provides precursors for generation of eicosanoids, su... | |||
TMPH-01222 | DGKA Protein, Human, Recombinant (His) | Human | E. coli |
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pa... | |||
TMPK-00028 | PLA2G1B Protein, Human, Recombinant (hFc) | Human | HEK293 |
Phospholipase A2 (PLA2) plays crucial roles in diverse cellular responses, including phospholipid digestion and metabolism, host defense and signal transduction. PLA2 provides precursors for generation of eicosanoids, su... | |||
TMPY-02055 | ENPP2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... |