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T7605 |
Avermectin B1a
|
Abamectin B1a,Avamectin B1a |
Antibiotic
,
Parasite
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Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent . |
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T13303 |
Virginiamycin M1
|
Pristinamycin IIA,Ostreogrycin A |
Antibacterial
|
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Virginiamycin M1 (Pristinamycin IIA) is a macrocyclic lactone peptide antibiotic and is a member of the streptogramin A group of antibiotics. |
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T19637 |
Aluminum phthalocyanine chloride
|
Phthalocyanine Chloroaluminum,Chloroaluminum Phthalocyanine |
Others
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Aluminum phthalocyanine chloride (Phthalocyanine Chloroaluminum) is an intensely blue-green-colored aromatic macrocyclic compound that is widely used in dyeing. Aluminum phthalocyanine chloride is a powerful photosensiti... |
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T4072 |
Methyl-β-cyclodextrin
|
Methyl-beta-cyclodextrin,beta-Cyclodextrin methyl ethers |
Others
|
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Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a macrocyclic compound used as a solubilizer for hydrophobic compounds in biological experiments. Methyl-β-cyclodextrin is also a lipid raft inhibitor with cholesterol-... |
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T0124 |
UK-124114
|
UNII-A2669OWX9N,Selamectin |
Others
|
|
UK-124114 (Selamectin) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel... |
|
T4059 |
Selamectin
|
UK-124114 |
Chloride channel
,
P-gp
,
Parasite
|
|
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel... |
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T33544 |
Myrotoxin B
|
Myrotoxin-B |
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Myrotoxin B is a macrocyclic trichothecene first isolated in 1985. |
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T31258 |
Deacylgymnemic acid
|
DAGA |
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Deacylgymnemic acid is a macrocyclic compound for proteomics research. |
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T70422 |
MDL-104168
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|
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MDL-104168 is a macrocyclic HIV-protease inhibitor. |
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T24195 |
Jatrophone
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NSC-135037,NSC135037,Jatropha principle,NSC 135037 |
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Jatrophone is a novel inhibitor of the macrocyclic diterpenoid tumor. |
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T71383 |
NB-533
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|
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NB-533 is a macrocyclic peptidic BACE-1 inhibitor. |
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T68278 |
NB-216
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NB-216 is a macrocyclic peptidic BACE-1 inhibitor. |
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T24193 |
Janthinocin C
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|
|
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Janthinocin C is a novel macrocyclic peptide lactone antibiotic. |
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T24192 |
Janthinocin B
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Janthinocin B is a novel macrocyclic peptide lactone antibiotic. |
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T24191 |
Janthinocin A
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|
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Janthinocin A is a macrocyclic peptide lactone antibiotic. |
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T19098 |
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)
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Others
|
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2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a macrocyclic DOTA derivative designed for tumor pretargeting. |
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T70457 |
MDL-73669
|
|
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MDL-73669 is a macrocyclic HIV-protease inhibitor that contains a difluorostatone peptide mimetic. |
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T12033 |
Micrococcin P1
|
|
HCV Protease
|
|
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM) |
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T70458 |
FXIa-6f
|
|
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FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species |
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T68335 |
MK-1220
|
|
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MK-1220 is a novel Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure. |
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T25882 |
7-O-Demethyl rapamycin
|
CJ 12263,CJ12263,7-O-Demethyl Rapammune,Novolimus (80%),7-O-Demethyl Cypher,Novolimus,CJ-12263 |
|
|
Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose. |
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T31360 |
Deepoxy-deoxynivalenol
|
DOM-I,DOM-1 |
|
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Deepoxy-deoxynivalenol is Metabolite of deoxynivalenol. Deepoxydeoxynivalenol is a macrocyclic polyol compound for proteomics research. Environmental contaminants; Food contaminants. |
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T26076 |
Rhizoxin
|
WF1360,WF 1360,WF-1360 |
|
|
Rhizoxin is an antitumor drug isolated from the fungus Rhizopus chinensis. It is a macrocyclic lactone compound that binds to tubulin and inhibits microtubule assembly. |
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T40838 |
20-O-Demethyl-AP3
|
20-O-Demethyl-AP3 |
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20-O-Demethyl-AP3 is a secondary metabolite derived from Ansamitocin P-3, and Ansamitocin P-3 is a macrocyclic antitumor antibiotic exerting its therapeutic effects by inhibiting microtubules. |
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T8675 |
Vaniprevir
|
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Others
|
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Vaniprevir is a macrocyclic hepatitis C virus NS3/4a protease inhibitor and is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir has good plasma exposure and excellent liver exposure... |
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T82958 |
ASGPR modulator-1
|
|
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Compound 5TJX (ASGPR modulator-1) is a macrocyclic compound utilized in the study of protein-protein interactions [1]. |
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T11972 |
Mcl-1 inhibitor 3
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|
BCL
|
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Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an... |
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T82650 |
Cy5-PEG7-endo-BCN
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|
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Cy5-PEG7-endo-BCN is a Cyanine 5 (Cy5) dye derivative featuring seven polyethylene glycol (PEG) units and the lipophilic bidentate macrocyclic ligand endo-BCN. This compound readily participates in click chemistry reacti... |
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T82678 |
Coumarin-C2-exo-BCN
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Coumarin-C2-exoBCN is a dye derivative of Coumarin featuring the hydrophilic bidentate macrocyclic ligand exo-BCN, which is conducive to further synthesis of macrocyclic complexes. Within the realm of click chemistry, ex... |
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T82659 |
Cy3-PEG2-endo-BCN
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|
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Cy3-PEG2-endo-BCN, a Cyanine 3 (Cy3) dye derivative with two polyethylene glycol (PEG) units, incorporates the hydrophobic bidentate macrocyclic ligand endo-BCN, which facilitates the synthesis of macrocyclic complexes. ... |
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T82652 |
Cy5-PEG2-exo-BCN
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Cy5-PEG2-exo-BCN, a Cyanine 5 (Cy5) dye derivative, incorporates two polyethylene glycol (PEG) units and features the hydrophilic bidentate macrocyclic ligand BCN. This compound is utilized in the synthesis of macrocycli... |
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T82651 |
Cy5-PEG3-endo-BCN
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|
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Cy5-PEG3-endo-BCN, a Cyanine 5 (Cy5) dye derivative, comprises three polyethylene glycol (PEG) units and the lyophilic bidentate macrocyclic ligand endo-BCN. The endo-BCN moiety facilitates the synthesis of macrocyclic c... |
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T80538 |
Lib2-1
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|
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Lib2-1, a macrocyclic peptide, inhibits the interaction between IL-17C and IL-17RE and is applicable in the study of autoimmune and inflammatory diseases [1]. |
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T34053 |
Phthalocyanine
|
|
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Phthalocyanine is an intensely blue-green-coloured aromatic macrocyclic compound that is widely used in dyeing. Phthalocyanine can be used as an agent for Photodynamic Therapy and Imaging. Phthalocyanines form coordinati... |
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T79719 |
8304-vs
|
|
Parasite
|
|
8304-vs is a macrocyclic anti-Plasmodial compound that irreversibly binds to and inhibits the Plasmodium proteasome, effectively halting the growth of Plasmodium falciparum [1]. |
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T74390 |
VD2173
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|
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VD2173, a macrocyclic peptide inhibitor with a side chain cyclization, effectively inhibits HGF-activating serine proteases including matriptase and hepsin, and is utilized in lung cancer research [1]. |
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T76276 |
Zilucoplan
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|
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Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide and potent complement component 5 (C5) inhibitor, is utilized in the study of immune-mediated necrotising myopathy (IMNM) [1] [2]. |
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T78042 |
JB-95 acetate
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JB-95 acetate, a β-hairpin macrocyclic peptide, demonstrates potent antimicrobial properties, selectively compromising the outer membrane of Escherichia coli while sparing the inner membrane [1]. |
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T76231 |
Cyclotheonellazole A
|
|
|
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Cyclotheonellazole A, a macrocyclic peptide naturally occurring, serves as a potent inhibitor of elastase (IC50 = 0.034 nM) and chymotrypsin with an IC50 of 0.62 nM [1] [2]. |
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T36885 |
BMSpep-57 hydrochloride
|
|
|
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BMSpep-57 hydrochloride, a potent macrocyclic peptide, competitively inhibits PD-1/PD-L1 interaction, exhibiting an IC50 value of 7.68 nM. It binds to PD-L1 with dissociation constants (Kds) of 19 nM and 19.88 nM as dete... |
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T71853 |
Enzastaurin HCl
|
|
|
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Enzastaurin HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin HCl selectively inhibits protein kina... |
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T69354 |
Enzastaurin 2HCl
|
|
|
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Enzastaurin 2HCl, also known as DB-102 and LY317615, is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, Enzastaurin 2HCl selectively inhibits protein ki... |
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T63713 |
Mytoxin B
|
|
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Mytoxin B is a macrocyclic endolipid that acts like LY294002 and is also an ADC cytotoxin (ADC cytotoxin). mytoxin B is able to exploit the PI3K/Akt pathway and thus induce apoptosis. |
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T80083 |
Zilucoplan TFA
|
RA101495 TFA |
Complement System
|
|
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5). It has applications in the study of immune-mediated necrotising myopathy (IMNM) [1] [2]. |
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T39106 |
BMSpep-57
|
|
|
|
BMSpep-57, a potent macrocyclic peptide inhibitor, competitively disrupts the PD-1/PD-L1 interaction, demonstrating a significant inhibitory concentration (IC50) of 7.68 nM. It exhibits binding affinity towards PD-L1 wit... |
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T62150 |
Cap-dependent endonuclease-IN-25
|
|
|
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Cap-dependent endonuclease-IN-25 is a macrocyclic pyridoxal derivative and a potent inhibitor of cap-dependent nucleic acid endonucleases (CEN). The Cap-dependent endonuclease IN-25 has potential for the study of viral i... |
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T76224 |
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)
|
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Compound 40, NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal), a macrocyclic analogue of Ape13, acts as a potent APJ agonist with a Ki of 5.7 nM. It demonstrates favorable Gα12-biased signaling and possesses an enhanced in vivo half-life... |
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T35746 |
Milbemycin A3
|
|
|
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Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound... |
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T61424 |
OD36 hydrochloride
|
OD 36 hydrochloride,OD-36 hydrochloride |
ALK
,
RIP kinase
|
|
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of the ALK2 kinase and effectively antago... |
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T82658 |
Cy3-PEG2-exo-BCN
|
|
|
|
Cy3-PEG2-exo-BCN is a derivative of the Cyanine 3 (Cy3) dye featuring two polyethylene glycol (PEG) units. It incorporates the hydrophilic bidentate ligand exo-cyclooctyne (BCN), which can be further used to synthesize m... |
