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T36421 |
Immuno-Oncology Screening Library
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The Immuno-Oncology Screening Library consists of 2 plates and contains more than 90 cancer and immunology-associated compounds in a 96-well Matrix tube rack format as 10 mM stock solutions in DMSO. This library include... |
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T10777 |
CG347B
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HDAC
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CG347B is a selective inhibitor of HDAC6. |
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T0964 |
Floxuridine
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5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640 |
Apoptosis
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Nucleoside Antimetabolite/Analog
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Others
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DNA/RNA Synthesis
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Antibacterial
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HSV
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Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. |
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T4314 |
EPZ020411
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EPZ020411 2HCl |
Histone Methyltransferase
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EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM). |
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T21322 |
Mavelertinib
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PF 06747775,PFE-X775,PF-06747775,PF-7775,PF 6747775,PF6747775 |
EGFR
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Mavelertinib (PF-06747775) is an orally available, selective and potent EGFR tyrosine kinase (EGFR TKI) inhibitor with inhibitory effects on T790M/L858R and T790M/Del, and can be used in the study of oncology and respira... |
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T9523 |
TGFβRI-IN-3
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TGF-beta/Smad
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TGFβRI-IN-3 inhibits TGFβR1 with an IC 50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology [1]. |
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T27643 |
Izonsteride
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LY-320236,LY320236,UNII-A5E8C36F34 |
Reductase
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Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is used in the treatment of oncology and genitourinary disorders, ... |
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T9619 |
I-BET567
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I-BET567, a potent pan-BET inhibitor with oral activity, demonstrates pIC50 values of 6.9 and 7.2 for BRD4 BD1 and BD2, respectively. This compound has exhibited efficacy in mouse models of oncology and inflammation [1]. |
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T50100 |
3-hydroxy-3-phenylpentanamide
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Others
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3-hydroxy-3-phenylpentanamide is a chiral compound belonging to the class of beta-hydroxyamides. In neurology, it has been shown to have neuroprotective effects against ischemic brain injury and cerebral hemorrhage. In p... |
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T26723 |
AZD8542
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AZD-8542,AZD 8542 |
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AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic. |
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T31410 |
D-Fluoromethyltyrosine F-18
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BAY 86 9596,BAY 869596,BAY 86-9596,J2.566.882K,BAY-86-9596 F-18 |
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Fluoroethyl-l-tyrosine (18F) or 18F-FET is a neuro-oncology PET tracer. |
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T82920 |
Barzuxetan
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CHX-A''-DTPA-NCS |
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Barzuxetan is a potential research tool in oncology [1]. |
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T70870 |
AC430
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AC430 is a potent and specific small molecule inhibitor of janus kinase 2 (JAK2), which has been implicated as a target for therapy in both oncology and autoimmune disease. AC430 is currently being developed by Ambit. In... |
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T74666 |
KTX-497
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KTX-497, an IRAK4 degrader, demonstrates a potent DC50 value of 3 nM. It is utilized in oncology research[1]. |
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T74667 |
KTX-612
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KTX-612 is a compound that serves as an orally active IRAK4 degrader, exhibiting a DC50 value of 7 nM. It is primarily utilized in oncology research [1]. |
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T61336 |
Numidargistat dihydrochloride
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Numidargistat dihydrochloride (CB-1158) is a highly potent and orally active chemical compound that effectively inhibits arginase. It exhibits IC50 values of 86 nM and 296 nM for recombinant human arginase 1 and 2, respe... |
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T79018 |
GSK217
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Epigenetic Reader Domain
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GSK217 is a potent and selective inhibitor of the bromo and extraterminal domain (BET) second bromodomain (BD2) with high solubility, utilized in oncology and immune inflammation research [1]. |
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T69751 |
UK-356202
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UK-356,202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM). Urokinase plasminogen activator (uPA, urokinase) is a trypsinlike serine protease and a therapeutical target for many cancer types, ... |
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T63418 |
GSK040
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GSK040, a potent and highly selective inhibitor of BET BD2, exhibits a pIC50 of 8.3, demonstrating over 5000-fold selectivity against BET BD1 (pIC50=4.6). This compound is primarily utilized in oncology and immunology re... |
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T80141 |
Crotalicidin
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Crotalicidin, obtained from rattlesnake venom, is both an antimicrobial and anti-tumor peptide with potent efficacy against Gram-negative bacteria and cancerous cells, showing promise for research in microbial infections... |
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T73390 |
I-BET432
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I-BET432, a BET inhibitor, targets both the N-terminal (BD1) and C-terminal (BD2) bromodomains of BRD4, exhibiting pIC50 values of 7.5 and 7.2, respectively. As an orally administered candidate, I-BET432 holds potential ... |
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T73296 |
IBRD4-BD1
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iBRD4-BD1 is a selective inhibitor of the BRD4 bromodomain, exhibiting inhibition activity with an IC50 value of 12 nM. It is utilized in the research of inflammation and oncology. |
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T77040 |
Iparomlimab
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Iparomlimab, an IgG4κ anti-human PD-1/CD279/PDCD1 antibody, additionally binds to the human monoclonal PSB103 γ4-chain, forming a dimer through disulfide linkage with the human monoclonal PSB103 κ-chain. It is utilized i... |
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T36761 |
KRAS inhibitor-10
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KRAS inhibitor-10 (WO2021005165 A1, compound 11) is a potent and selective inhibitor of RAS proteins, with a specific focus on KRAS proteins. This orally active anti-cancer agent demonstrates strong efficacy in cancer re... |
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T82060 |
Interleukin-6 fragment (human)
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Interleukin-6 Fragment (human) is a pleiotropic cytokine originating from both lymphocytes and non-lymphocytes, encoded by a gene on human chromosome 7 spanning roughly 5 kilobases. This fragment shows promise for use in... |
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T81708 |
Nagrestipen
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Nagrestipen, a variant of the human macrophage inflammatory protein-1 alpha (MIP-1α), also referred to as ECI 301, exhibits antitumor activity. It is employed in therapeutic trials focused on cancer, assessing its effica... |
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T79313 |
BI 7446
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STING
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BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor ... |
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T37014 |
Inupadenant
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Inupadenant is an orally active, highly selective A2A receptor antagonist. Inupadenant is not brain-penetrant. Inupadenant has potent anti-tumor activity[1].
[1]. Laurence Buisseret, et al. Phase 1 trial of the adenosine... |
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T76986 |
Tarlatamab
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Tarlatamab (AMG-757) is a first-in-class, high-affinity, bispecific T-cell engager (BiTE) antibody that selectively targets delta-like ligand 3 (DLL3), a protein predominantly expressed in small-cell lung cancer (SCLC) t... |
