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T5023 |
Propiverine hydrochloride
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|
Others
,
Calcium Channel
,
AChR
|
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Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB). |
|
T19723 |
AMTB hydrochloride
|
AMTB |
TRP/TRPV Channel
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|
AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl... |
|
T9419 |
Fesoterodine
|
(R) Fesoterodine |
AChR
|
|
Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB). |
|
T4612 |
NS309
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|
EGFR
,
Potassium Channel
,
HER
|
|
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat... |
|
T1472 |
Trospium chloride
|
Spasmex,Sanctura |
AChR
|
|
Trospium chloride (Spasmex) is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium chloride has not been implicated in causing liver enzyme elevations o... |
|
T1475 |
Fesoterodine fumarate
|
Toviaz,SPM 907 |
AChR
|
|
Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo... |
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T0703 |
Flavoxate hydrochloride
|
Flavoxate HCl,NSC-114649,DW61,Rec-7-0040 |
AChR
|
|
Flavoxate hydrochloride (DW61) , a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic. |
|
T15273 |
Fedovapagon
|
VA483,A106483 |
Vasopressin Receptor
|
|
Fedovapagon (VA106483) is a selective and potent agonist of the vasopressin V2 receptor (V2R) that inhibits the growth of intersegmental vessels in zebrafish. Fedovapagon can be used to study overactive bladder, nocturia... |
|
T1671 |
Mirabegron
|
YM178 |
Adrenergic Receptor
|
|
Mirabegron (YM178) is a beta-3 adrenergic agonist that is used for treatment of overactive bladder syndrome. |
|
T1534 |
Darifenacin hydrobromide
|
Darifenacin HBr,UK-88525 |
AChR
|
|
Darifenacin hydrobromide (UK-88525) is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome. |
|
T1049L |
Oxybutynin
|
Oxytrol,Ditropan,Oxibutyninum |
Potassium Channel
,
AChR
|
|
Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome. |
|
T12970 |
Solabegron
|
GW 427353 |
Adrenergic Receptor
|
|
Solabegron (GW 427353) is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladd... |
|
T76690 |
Mavrilimumab
|
CAM 3001 |
Virus Protease
,
CSF-1R
|
|
Mavrilimumab (CAM 3001) is a monoclonal antibody with antiviral activity that has an affinity for the α subunit of the granulocytic-macrophage colony-stimulating factor (GM-CSF) receptor and blocks downstream intracellul... |
|
T0357 |
Potassium iodide
|
|
Tyrosinase
|
|
Potassium iodide is used as the treatment of overactive thyroid and as protection of the thyroid gland from the influences of radiation from swallowed or inhaled radioactive iodine. It may be used after accidental exposu... |
|
T11275 |
Fesoterodine L-mandelate
|
|
Others
|
|
Fesoterodine L-mandelate is a efficacious antimuscarinic agent for the overactive bladder (OAB). |
|
T35052 |
Vibegron
|
MK4618,MK 4618,MK-4618 |
|
|
Vibegron (MK-4618) is an effective and selective Beta 3 adrenergic receptor agonist, used to treat overactive bladder (OAB). |
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T70338 |
Lu AF58786
|
|
|
|
Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively. |
|
T28465 |
PSD-506
|
PSD 506,RO 3202904,RO3202904,RO-3202904 |
|
|
PSD-506, a muscarinic M2/M3 antagonist, is used potentially for the treatment of overactive bladder, and urinary incontinence. |
|
T28125 |
N-5984
|
N5984,KRP-204,KRP 204,KRP204 |
|
|
N-5984, a β3-adrenergic receptor agonist, is used potentially for the treatment of obesity, overactive bladder and type 2 diabetes. |
|
T29208 |
ZD-0947
|
AZD0947,AZD-0947,ZD 0947,AZD 0947 |
|
|
ZD-0947, a K(ATP) channel activator, is used potentially for the treatment of overactive bladder (OAB). |
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T68548 |
Tolterodine Dimer
|
|
|
|
Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder. |
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T61438 |
Propiverine
|
|
|
|
Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscl... |
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T61357 |
EP3 antagonist 3
|
|
|
|
EP3 antagonist 3 (compound 2) is a highly effective and specific antagonist of the EP3 receptor. It displays significant oral bioavailability and exhibits a strong pKi value of 8.3. Furthermore, EP3 antagonist 3 possesse... |
|
T40161 |
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
|
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride,(Rac)-PNU-200577hydrochloride,(Rac)-Desfesoterodine hydrochloride |
|
|
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride, also known as (Rac)-Desfesoterodine hydrochloride, is an active metabolite of Tolterodine that functions as a mAChR antagonist. It exhibits significant affinity (K i value... |
|
T72091 |
ADRA1D receptor antagonist 1 free base
|
|
|
|
ADRA1D receptor antagonist 1 (free base) antagonist ( K i =1.6 nM). ADRA1D receptor antagonist 1 (free base) dose-dependently inhibits bladder contraction with an IC 30 value of 15 nM. ADRA1D receptor antagonist 1 (free... |
