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T15108 |
DG-041
|
|
Prostaglandin Receptor
|
|
DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per... |
|
T0328 |
Hexetidine
|
NSC-17764 |
Antibacterial
,
Antifungal
|
|
Hexetidine (NSC-17764) is a bactericidal and fungicidal antiseptic. It is used as a 0.1% mouthwash for local infections and oral hygiene. |
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T14369 |
AZD-0284
|
|
ROR
|
|
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. |
|
T7657 |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat
|
MOG (35-55) |
Others
|
|
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a truncated peptide derived from the human Myelin Oligodendrocyte Glycoprotein (MOG). |
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TP2045 |
CH 275
|
|
|
|
Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin r... |
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T68006 |
Orilotimod potassium
|
APO805K1 |
|
|
Orilotimod potassium (APO805K1) can be used to study plaque psoriasis. |
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T17038 |
Tepilamide fumarate
|
XP-23829 |
Others
|
|
Tepilamide fumarate (XP-23829) is an oral fumaric acid ester and is used in the research of moderate to severe chronic plaque psoriasis. |
|
T1147 |
Chlorhexidine dihydrochloride
|
Chlorhexidine hydrochloride,Chlorhexidine 2HCl,NSC-185 |
CAT
,
Cell wall
,
Antibacterial
,
Antibiotic
,
Antifection
|
|
Chlorhexidine dihydrochloride (NSC-185) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. |
|
T37445 |
Etanercept
|
|
TNF
|
|
Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β to the TNF receptors on cell surfaces, thereby rendering TN... |
|
T1000L |
Chlorhexidine diacetate
|
Hibitane diacetate,Chlorhexidine Acetate,Bactigras |
CAT
,
Antibacterial
,
Antibiotic
,
Antifection
|
|
Chlorhexidine diacetate (Bactigras) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. |
|
T0305 |
Erythrosine B
|
Erythrosine I,Erythrosin extra bluish,Erythrosin B |
Others
|
|
Erythrosine B (Erythrosine I) , a tetraiodofluorescein, is served as a red coloring in some foods (cherries, fish), as a disclosure of dental plaque, and as a stain of some cell types. Its structural was similar to thyro... |
|
T0578 |
Erythrosin B
|
Iodeosin,Tetraiodofluorescein |
Others
|
|
Erythrosin B (Iodeosin) , a tetraiodofluorescein, is used as a red coloring in some foods (cherries, fish), as a stain of some cell types, and as a disclosure of DENTAL PLAQUE. Its molecular structure is similar to THYRO... |
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T77170 |
Siplizumab
|
MEDI-507 |
Others
|
|
Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody targeting CD2. Siplizumab selectively depletes effector memory T cells and promotes relative expansion of alloreactive regulatory T cells in vitro. Siplizumab... |
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T9930 |
Secukinumab
|
|
IL Receptor
|
|
Secukinumab is a fully humanized monoclonal anti-IL-17A antibody and the first in its class to be approved by the US Food and Drug Administration for the treatment of moderate to severe plaque psoriasis. |
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T16094 |
MK-3328
|
|
Others
|
|
MK-3328 has a high affinity for β-Amyloid (IC50:10.5 nM), and can be used as a candidate PET ligand for clinical assessment of β-amyloid plaque load. MK-3328 is a potential treatment for Alzheimer's disease. |
|
T64167 |
Ifebemtinib
|
IN-10018,BI-853520 |
FAK
|
|
Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesoth... |
|
T76924 |
Efalizumab
|
Hu1124,HU 1124 |
Integrin
|
|
Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinoc... |
|
T0900 |
Cetylpyridinium chloride monohydrate
|
Hexadecylpyridinium chloride monohydrate |
Antibacterial
,
Antibiotic
|
|
Cetylpyridinium chloride monohydrate (Hexadecylpyridinium chloride monohydrate) , a cationic quaternary ammonium compound, is used in certain classes of throat sprays, mouthwashes, lozenges, toothpaste, nasal sprays, and... |
|
T38105 |
Ixekizumab
|
LY2439821 |
IL Receptor
,
Interleukin
|
|
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A with a Kd value of <3 pM.Ixekizumab blocks the binding of IL-17A to IL-17RA but not to other IL-17 ... |
|
T1267L |
Abacavir acetate
|
KM-133,KM133,KM 133 |
|
|
Abacavir acetate (Prurisol) has the potential to be used in the treatment of plaque psoriasis. |
|
T68494 |
Octenidine saccharin
|
|
|
|
Octenidine saccharin is a Dental Plaque Inhibitor |
|
T68705 |
Salifluor
|
|
|
|
Salifluor is a broad spectrum antimicrobial agent that has been investigated for its abilities to inhibit dental plaque formation. |
|
T38175 |
MPro N3
|
|
|
|
Coronavirus main protease (Mpro) inhibitor (respective IC50 values are 2.7, 4 and 8.8 μM for MHV-A29, HCoV-229E and FOPV replication in vitro). Inhibits viral cell infection in an MHV plaque reduction assay. Also inhibit... |
|
T69456 |
Melagatran monohydrate
|
|
|
|
Melagatran monohydrate is a thrombin inhibitor. Melagatran prevents tissue factor expression in human platelet-monocyte heterotypic complexes. Melagatran reduces advanced atherosclerotic lesion size and may promote plaqu... |
|
TP1494 |
β-Amyloid (4-10)
|
β-Amyloid 4-10 |
|
|
Antibodies corresponding to beta-amyloid (4-10) are effective in vivo inhibitors of cytotoxicity, amyloid plaque formation and special memory disturbances in mice. This peptide does not elicit an inflammatory response. |
|
TP2171 |
β-amyloid (12-28) (TFA) (107015-83-8 free base)
|
Amyloid β-Protein (12-28) (TFA),β-amyloid (12-28) (TFA) |
Others
|
|
β-amyloid (12-28) TFA, a peptide fragment of β-amyloid protein (β1-42), is the major component of senile plaque cores. β-amyloid (12-28) has aggregation properties and the potential for Alzheimer’s disease research. |
|
TP2135 |
CAC 253
|
|
|
|
Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's d... |
|
T69664 |
Umibecestat HCl
|
|
|
|
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD... |
|
T77098 |
Netakimab
|
|
|
|
Netakimab, an anti-IL-17 monoclonal antibody, is utilized in the research of ankylosing spondylitis, psoriatic arthritis, and moderate-to-severe plaque psoriasis [1] [2]. |
|
T78298 |
Alefacept
|
LFA 3TIP,Human LFA 3IgG fusion protein,BG 9273 |
|
|
Alefacept (BG 9273), a fusion protein combining human lymphocyte function-associated antigen 3 with immunoglobulin 1, is utilized in the research of chronic plaque psoriasis [1]. |
|
T76885 |
Sonelokimab
|
|
|
|
Sonelokimab (ALX 0761; M 1095) is a trivalent nanobody that combines monovalent camelid-derived nanobodies targeting human interleukin (IL)-17A and IL-17F, along with human serum albumin VHHs. This composition presents s... |
|
T21814 |
ONO 4817
|
|
|
|
ONO-4817 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor that potentially mitigates atherosclerotic neointimal proliferation and atheromatous plaque progression by suppressing matrix metalloproteinases (MMPs... |
|
T75779 |
β-Amyloid (12-28) (TFA)
|
|
|
|
β-Amyloid (12-28) (TFA), a peptide fragment of the β-amyloid protein (β1-42)—a 42 amino acid protein primarily found in senile plaque cores—exhibits aggregation properties. This compound holds significance for research i... |
|
T71306 |
Gemfibrozil-d6
|
|
|
|
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil redu... |
|
T78541 |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA
|
MOG (35-55) (TFA) |
|
|
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA, a minor constituent of central nervous system (CNS) myelin, demonstrates encephalitogenic properties by inducing T cell proliferation and... |
|
T63558 |
IRAK4-IN-21
|
|
|
|
IRAK4-IN-21 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 5 nM) and TAK1 (IC50: 56 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.17 μM. can be ... |
|
T63559 |
IRAK4-IN-22
|
|
|
|
IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN... |
|
T38118 |
Zanamivir-13C,15N2
|
Zanamivir-13C,15N2 |
|
|
Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus... |
|
T78542 |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate
|
MOG (35-55) (acetate) |
|
|
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) acetate, a minor component of CNS myelin, exhibits encephalitogenic activity by inducing T cell proliferation and a Th1 cytokine response, alo... |
|
T72893 |
AChE/MAO-IN-2
|
|
|
|
Dual AChE-MAO B-IN-5, an indanone derivative, serves as an effective dual inhibitor for AChE and MAO-B, displaying IC50 values of 0.0224 μM for AChE, 0.0412 μM for MAO-B, and 0.1116 μM for MAO-A. Additionally, it exhibit... |
|
T83710 |
Gastric Inhibitory Peptide (22-51) (human) TFA
|
GIP (22-51),Glucose-dependent Insulinotropic Peptide (22-51) |
|
|
Gastric inhibitory peptide (GIP) (22-51), a pro-atherogenic peptide comprised of 30 amino acids from the residues 22-51 of its precursor protein proGIP, is present in human plasma. It activates the degradation of IκB-α a... |
|
T72454 |
AChE/BChE/MAO-B-IN-4
|
|
|
|
AChE/BChE/MAO-B-IN-4, an indan-1-one derivative, serves as a potent inhibitor for both monoamine oxidase B (MAO-B) and acetylcholinesterase/butyrylcholinesterase (AChE/BChE) enzymes. It exhibits a strong inhibitory effec... |
