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TQ0084 |
Lumateperone Tosylate
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ITI-007 |
Dopamine Receptor
,
5-HT Receptor
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lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki: 32 nM). |
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T21069 |
Lumateperone
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ITI 722,ITI722,ITI-007,ITI007 |
5-HT Receptor
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Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM). |
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T3280 |
Clodronate disodium tetrahydrate
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clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium |
IL Receptor
,
TNF
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Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification. |
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T7386 |
Bretylium tosylate
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Others
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Bretylium tosylate is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters, a available antiarrhythmic drug for ventricular arrhythmias. |
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T21766 |
ML352
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ML352, a noncompetitive inhibitor of the presynaptic choline transporter (CHT), exhibits K i values of 92 nM in HEK293 cells with human CHT expression and 166 nM in mouse forebrain synaptosomes [1]. |
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T1540 |
Doxepin hydrochloride
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Toruan,Doxepin HCl,Aponal,Novoxapin |
P450
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
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Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap... |
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T22530 |
6-Chloromelatonin
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Melatonin Receptor
,
Dopamine Receptor
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6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]... |
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T7218 |
Endomorphin 2
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Opioid Receptor
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Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP. EM-2-IR fibers originated from primary afferent fibers f... |
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T0869 |
Atomoxetine hydrochloride
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Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
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Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou... |
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T12118 |
MSOP
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GluR
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MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR). |
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T10779 |
CGP 25454A
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Others
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CGP 25454A is a novel and selective antagonist of the presynaptic dopamine autoreceptor. |
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T23662 |
Aganodine
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Aganodin |
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Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors. |
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T71439 |
Opc 4392
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Opc 4392 is an agonist of presynaptic dopamine D(2) receptor. |
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T24462 |
Mezilamine
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Mezilamine is an antagonist of dopamine. It also blocks presynaptic but stimulating postsynaptic alpha-adrenoceptors. |
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T68767 |
Mezilamine HCl
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Mezilamine HCl is a dopamine antagonist, blocking presynaptic but stimulating postsynaptic alpha-adrenoceptors. |
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T38975 |
WAY-100135 dihydrochloride
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WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compou... |
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T78062 |
Dendrotoxin K TFA
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Potassium Channel
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Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1]. |
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T40541 |
α-Synuclein (61-75)
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α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disea... |
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T76187 |
Dendrotoxin K
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Dendrotoxin K, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by regulating the presynaptic spike waveform in a time-dependent manner [1]. |
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T68183 |
PPMC
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The alpha-adrenoceptors blocking effect of (N-piperidinomethyl)-2-chromanne was studied in vivo and in vitro in the rat. In the pithed rat, (N-piperidinomethyl)-2-chromanne (1 mg/kg i.v.) antagonized the pressor effects ... |
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T76199 |
α-Synuclein (61-75) (TFA)
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α-Synuclein (61-75) TFA is a fragment (residues 61-75) of the abundant neuronal protein α-Synuclein, which is predominantly located in presynaptic nerve terminals. α-Synuclein serves as a potential biomarker for Parkinso... |
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T78456 |
DASPEI
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DASPEI is a cationic styrenyl mitochondrial dye characterized by a large Stokes shift and excitation/emission wavelengths at 550/573 nm, yielding robust chromogenic properties. It effectively stains mitochondria in live ... |
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T60492 |
Lamotrigine hydrate
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Lamotrigine hydrate is an effective oral active anticonvulsant or antiepileptic agent that selectively blocks voltage-gated Na + channels, stabilizes presynaptic neuronal membranes and inhibits glutamate release. Lamotri... |
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T37608 |
Riluzole-13C,15N2
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Riluzole-13C,15N2 |
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Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic... |
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T68190 |
Carmoxirole (free base)
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Carmoxirole (free base) is a dopamine D2 receptor agonist with limited central activity that modulates sympathetic activation and subsequently reduces pre-load and afterload in animals. It was shown, that carmoxirole ind... |
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T70077 |
Fadolmidine HCl
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Fadolmidine, also known as MPV-2426, is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia. Fadolmidine displayed high affinity and full agonist efficacy at all three human alpha... |
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T20886 |
Atomoxetine
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Tomoxetine,HSDB7352,HSDB-7352,HSDB 7352 |
Norepinephrine
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Atomoxetine (HSDB 7352) is a selective norepinephrine inhibitor that may cause an increase in blood pressure by increasing norepinephrine concentrations in peripheral sympathetic neurons .Atomoxetine is a highly selectiv... |
