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T81283 |
RGD-targeted Proapoptotic Peptide
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RGD-Targeted Proapoptotic Peptide is a peptide that preferentially binds to integrins at sites of tumor angiogenesis through its C-terminal RGD-4C sequence (ACDCRGDCFC). |
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T6641 |
Rilmenidine Phosphate
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Apoptosis
,
Adrenergic Receptor
,
Autophagy
,
Imidazoline Receptor
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Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension. |
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TP2207 |
Pasireotide Acetate
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Somatostatin
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Pasireotide Acetate is a stable cyclohexapeptide somatostatin mimic |
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T12257 |
NSC 146109 hydrochloride
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Apoptosis
,
Others
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T6079 |
NVP-ADW742
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ADW742,ADW,GSK 552602A |
Apoptosis
,
IGF-1R
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NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
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T2111 |
Sepantronium bromide
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YM155 |
Survivin
,
Autophagy
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Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity. |
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T2453 |
BAM7
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BCL
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BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM). |
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T13867 |
RH01386
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Others
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RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ... |
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T4400 |
DIM-C-pPhOH
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CDIM8 |
Apoptosis
,
Others
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DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi... |
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T6301 |
Tosedostat
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CHR-2797 |
Aminopeptidase
,
AChR
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Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted intracellularly into a poorly membrane-permeable active metabo... |
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T12369 |
Pasireotide pamoate
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SOM230 pamoate |
Others
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Pasireotide pamoate is a stable cyclohexapeptide somatostatin mimic. Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity. |
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T15723 |
LBW242
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Others
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LBW242 is a 3-mer and Smac mimetic and is an effective and orally active proapoptotic IAP inhibitor. LBW242 has activity against multiple myeloma and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian ... |
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T26709 |
Azadirone
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Azadirone is a limonoid tetranortriterpene. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR4 and DR5 signaling, do... |
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T72658 |
CRIPGBM chloride
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cRIPGBM chloride is an orally active, proapoptotic compound derived from glioblastoma multiforme (GBM) cancer stem cells (CSCs). It specifically targets receptor-interacting protein kinase 2 (RIPK2) to trigger caspase 1-... |
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T19250 |
CRIPGBM
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TNF
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cRIPGBM, a proapoptotic derivative of RIPGBM, selectively induces apoptosis in GBM cancer stem cells (CSCs) by targeting receptor-interacting protein kinase 2 (RIPK2), demonstrating an EC50 of 68 nM in GBM-1 cells [1]. |
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T70430 |
XK469
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XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases,... |
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T82239 |
HAP-1
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HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin. When fused with the antimicrobial peptide (KLAK)2, HAP-1 form... |
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T75248 |
Pasireotide (diaspartate)
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Pasireotide diaspartate (SOM230), a long-acting cyclohexapeptide and somatostatin analog, enhances agonist activity across somatostatin receptor subtypes (sst1/2/3/4/5, with pK i values of 8.2, 9.0, 9.1, <7.0, and 9.9, r... |
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T35588 |
Ganglioside GM3 Mixture (sodium salt)
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Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. It suppresses angiogenesis and reduce... |
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T78708 |
JAK/HDAC-IN-2
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JAK
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JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations. This compound exhibits proapoptotic properties, inhibits histone deace... |
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T36963 |
CAY10503
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CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of... |
