|
T7776 |
ADH-503
|
GB1275 |
Complement System
|
|
ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. |
|
T1676 |
Rosuvastatin
|
ZD 4522 |
Potassium Channel
,
HMG-CoA Reductase
,
Autophagy
|
|
Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting... |
|
T1510 |
Rosuvastatin calcium
|
ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium |
Potassium Channel
,
HMG-CoA Reductase
,
Autophagy
|
|
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. |
|
T13379 |
(Z)-Leukadherin-1
|
ADH-503 free base |
Complement System
|
|
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b. |
|
T14077 |
A-935142
|
|
EGFR
|
|
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. a-935142 enhances hERG currents by slowing inactivation, promoting activation, reducing inactivation, shortening atrial and ventricular re... |
|
T7195 |
GSK369796 Dihydrochloride
|
N-tert-butylisoquine |
Potassium Channel
,
Parasite
|
|
GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM) |
|
T6476 |
Dofetilide
|
UK 68789,UK-68798,Tikosyn |
Potassium Channel
|
|
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik... |
|
T16444 |
PD-118057
|
|
Potassium Channel
,
HER
|
|
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential ... |
|
T25934 |
Pentisomide
|
Pentisomidum |
|
|
Pentisomide is a class-I antiarrhythmic agent with a marked effect on depolarization (action of class Ia and Ic) and on repolarization. Pentisomide dose-dependently inhibited ischaemia-reperfusion arrhythmia. Pentisomide... |
|
T36561 |
(3S)-hydroxy Quinidine
|
|
|
|
(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 be... |
