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Search Results for " uPAR "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T61932	Nesuparib	JPI-547/OCN-201	PARP , Wnt/beta-catenin
	Nesuparib (JPI-547/OCN-201) is a potent PARP inhibitor with inhibitory effects on PARP and TNKS1.Nesuparib has antitumor activity and can be used in the treatment of tumors, endocrine and metabolic disorders, genitourina...		PARP , Wnt/beta-catenin
T77566	(3aR,9aR)-Fluparoxan		Adrenergic Receptor
	(3aR,9aR)-Fluparoxan is a highly selective and potent adrenergic receptor α2B antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases.		Adrenergic Receptor
T1827	Buparlisib	BKM120,NVP-BKM120	Apoptosis , PI3K
	Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).		Apoptosis , PI3K
T77565	Fluparoxan hydrochloride		Adrenergic Receptor
	Fluparoxan hydrochloride is a highly selective and potent α2-adrenoceptor antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases.		Adrenergic Receptor
T77412	Lupartumab	BAY 1112623	Others
	Lupartumab (BAY 1112623) is an anti-LYPD3 (C4.4A) monoclonal antibody that can be used to synthesize antibody-active molecular couplers that can be used to study LYPD3-associated tumor diseases.		Others
T4269	Buparvaquone	Butalex,BW 720C	Antibiotic , Parasite
	Buparvaquone (BW 720C) is a hydroxynaphthoquinone antiprotozoal drug related to atovaquone and parvaquone.		Antibiotic , Parasite
T80918	Tuparstobart	Incagn-02385
	Tuparstobart (Incagn-02385) is an IgG1κ monoclonal antibody that targets the immune checkpoint receptor protein LAG-3, which is predominantly expressed on activated T cells, NK cells, B cells, and plasmacytoid dendritic ...
T16365	Buparlisib Hydrochloride	NVP-BKM120 Hydrochloride,BKM120 Hydrochloride	Others
	Buparlisib Hydrochloride is an inhibitor of pan-class I PI3K (IC50: 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively).		Others
T11992	Mefuparib hydrochloride	MPH	PARP
	Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, substrate-competitive and selective PARP1/2 inhibitor with IC...		PARP
T68074	Fluparoxan
	Fluparoxan is a highly selective and potent alpha 2-adrenoceptor antagonist.
T70785	Mefuparib Free Base
	Mefuparib Free Base is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively. Mefuparib (CVL218), has been shown to have promising antiviral activity against the virus that cause...
T27340	Fluparoxan HCl	GR50360,GR 50360,Fluparoxan hydrochloride,GR-50360A,GR-50360
	Fluparoxan is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold).
TP2338L	Cenupatide acetate	Cenupatide acetate(1006388-38-0 Free base)	Others
	Cenupatide acetate is an urokinase plasminogen activator receptor (uPAR) inhibitor for treating disorders associated altered cell migration, such as cancer.		Others
T11666	IPR-803		Serine/threonin kinase
	IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM.		Serine/threonin kinase
T26629	Angstrom6	A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide	PAI-1
	Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.Angstrom6 has antitumor a...		PAI-1
TP2338	Cenupatide	UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2)
	Cenupatide is a urokinase plasminogen activator receptor (uPAR) inhibitor. Cenupatide inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of STZ-induced diabetes. Cenupa...

Compounds

Nesuparib

T61932

Synonym: JPI-547/OCN-201

Target: PARP, Wnt/beta-catenin

(3aR,9aR)-Fluparoxan

T77566

Synonym:

Target: Adrenergic Receptor

Buparlisib

T1827

Synonym: BKM120,NVP-BKM120

Target: Apoptosis, PI3K

Fluparoxan hydrochloride

T77565

Synonym:

Target: Adrenergic Receptor

Synonym: Butalex,BW 720C

Target: Antibiotic, Parasite

Tuparstobart

T80918

Synonym: Incagn-02385

Target:

Buparlisib Hydrochloride

T16365

Synonym: NVP-BKM120 Hydrochloride,BKM120 Hydrochloride

Target: Others

Mefuparib hydrochloride

Synonym: GR50360,GR 50360,Fluparoxan hydrochloride,GR-50360A,GR-50360

Target:

Cenupatide acetate

TP2338L

Synonym: Cenupatide acetate(1006388-38-0 Free base)

Target: Serine/threonin kinase

Angstrom6

T26629

Synonym: A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide

Target: PAI-1

Cenupatide

TP2338

Synonym: UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2)

Target:

カタログ番号	製品名	別名	ターゲット
TN6762	(+)-Cuparene		Others
	(+)-Cuparene is a bioactive chemical.		Others
TN3469	Aucuparin	2,6-dimethoxy-4-phenylphenol	NADPH-oxidase
	Aucuparin (2,6-dimethoxy-4-phenylphenol) is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP showed clear scavenging act...		NADPH-oxidase
TN2693	2,3-Dihydro-12,13-dihydroxyeuparin		Others
	2,3-Dihydro-12,13-dihydroxyeuparin is a natural product for research related to life sciences. The catalog number is TN2693 and the CAS number is 135531-75-8.		Others
T81653	Noraucuparin
	Noraucuparin, a biphenyl-type phytoalexin with antifungal properties, can be isolated from the leaves of Sorbus pohuashanensis [1].
TN4258	Isocuparenal		Others
	Isocuparenal is a natural product for research related to life sciences. The catalog number is TN4258 and the CAS number is 16982-01-7.		Others
TN2596	12-Hydroxy-2,3-dihydroeuparin		Others
	12-Hydroxy-2,3-dihydroeuparin is a natural product of Eupatorium, Asteraceae. The catalog number is TN2596 and the CAS number is 68776-42-1. 12-Hydroxy-2,3-dihydroeuparin can be used as a reference standard.		Others
TN4036	Euparone		Others
	Euparone is a benzofuran from Ruscus aculeatus L..		Others
TN1632	Euparin		Antifection
	Euparin exhibits a moderate antioxidant activity, it also exhibits antifungal activity against Trichophyton mentagrophytes. Euparin has antiviral activity, it exerts its effect during the early events of the replication ...		Antifection
TN5160	Trans-2,3-Dihydro-3-ethoxyeuparin		Others
	trans-2,3-Dihydro-3-ethoxyeuparin is a natural product for research related to life sciences. The catalog number is TN5160 and the CAS number is 1015698-14-2.		Others
TN5161	Trans-2,3-Dihydro-3-hydroxyeuparin		Others
	trans-2,3-Dihydro-3-hydroxyeuparin is a natural product for research related to life sciences. The catalog number is TN5161 and the CAS number is 64185-57-5.		Others

天然物製品

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

2,3-Dihydro-12,13-dihydroxyeuparin

12-Hydroxy-2,3-dihydroeuparin

trans-2,3-Dihydro-3-ethoxyeuparin

TN5160

Synonym:

Target: Others

trans-2,3-Dihydro-3-hydroxyeuparin

TN5161

Synonym:

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01257	uPAR/PLAUR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	uPAR/PLAUR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.4 kDa and the accession number is P35456-1.
TMPY-02141	uPAR/PLAUR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	uPAR/PLAUR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q03405-1.
TMPY-01017	uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293 Cells
	uPAR/PLAUR Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 58 kDa and the accession number is P35456-1.
TMPK-01175	uPAR/PLAUR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasmin...
TMPK-00228	uPAR/PLAUR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasmin...
TMPK-00227	uPAR/PLAUR Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasmin...
TMPK-00216	uPAR/PLAUR Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293 Cells
	The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasmin...
TMPK-00226	uPAR/PLAUR Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasmin...
TMPK-00215	uPAR/PLAUR isoform 1 Protein, Mouse, Recombinant (His & Avi)	Mouse	HEK293 Cells
	The receptor (u-PAR) for urokinase plasminogen activator (u-PA) is a three-domain protein, GPI-anchored to the cell surface, which focuses the enzymatic activity of u-PA, and allows the cell surface activation of plasmin...
TMPH-03397	uPAR/PLAUR Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. uPAR/PLAUR Protein,...
TMPK-01225	MRC2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	MRC2 (Mannose Receptor C Type 2) is a constitutively recycling endocytic receptor belonging to the mannose receptor family, which has been found to be closely involved with cancer metastasis. MRC2 expresses an extracellu...
TMPJ-00541	CD177 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is express...
TMPJ-00709	LY6H Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Lymphocyte Antigen 6H (LY6H) is a novel member of the LY6 family of glycosylphosphatidylinositol-anchored cell surface glycoproteins. LY6H contains one UPAR/Ly6 domain. Human LY6H is synthesized as a 140 amino acid precu...