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CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.
Cat. No. 製品名 CAS No. Purity Chemical Structure
TP1364L ALX 40-4C acetate 98%
ALX 40-4C acetate is a CXCR4 inhibitor of the chemokine receptor (Ki = 1 μM) and suppresses the replication of X4 strains of HIV-1. ALX 40-4C acetate is an antag...
TP2051L CTCE 9908 acetate 98%
CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.
T76741 Eldelumab 946414-98-8 98%
Eldelumab (BMS-936557) is a humanized anti-IP-10 IgG type 1 monoclonal antibody with inhibitory activity against CXCL10.Eldelumab has anti-inflammatory activity ...
T9721 ML339 2579689-83-9 98%
ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
T5849 JMS-17-2 1380392-05-1
JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
T1776L Plerixafor octahydrochloride 155148-31-5
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting ...
TP2112L TC14012 acetate
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent C...
T14665L Motixafortide TFA(664334-36-5,Free) 100%
Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL...
T1955 SB225002 182498-32-4 96.86%
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
T3992 MSX-122 897657-95-3 97.02%
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
T6764L ATI-2341 acetate(1337878-62-2 free base) 97.14%
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. ATI-2341 acetate activates inhibitory heterotrimeric G protein (G...
T12705 Reparixin L-lysine salt 266359-93-7 97.31%
Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
T15805L LY2510924 acetate(1088715-84-7 free base) 97.32%
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.
T16850 SB-265610 211096-49-0 97.67%
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calciu...
T26035 Rac-NBI-74330 473722-68-8 97.85%
rac-NBI-74330 is an effective and selective CXCR3 antagonist.
T1776 Plerixafor 110078-46-1 98%
Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
T5193 Danirixin 954126-98-8 98%
Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
T11693L IT1t dihydrochloride 1092776-63-0 98.03%
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
T12269 NUCC-390 1060524-97-1 98.18%
NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compou...
T76662 Ac-Pro-Gly-Pro-OH 292171-04-1 98.32%
Ac-Pro-Gly-Pro-OH is an acetyl-modified tripeptide compound that acts as a CXCR2 agonist.Ac-Pro-Gly-Pro-OH exhibits bactericidal and anti-inflammatory activity, ...
ALX 40-4C acetate
TP1364L
ALX 40-4C acetate is a CXCR4 inhibitor of the chemokine receptor (Ki = 1 μM) and suppresses the replication of X4 strains of HIV-1. ALX 40-4C acetate is an antag...
CTCE 9908 acetate
TP2051L
CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.
Eldelumab
T76741
Eldelumab (BMS-936557) is a humanized anti-IP-10 IgG type 1 monoclonal antibody with inhibitory activity against CXCL10.Eldelumab has anti-inflammatory activity ...
ML339
T9721
ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.
JMS-17-2
T5849
JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
Plerixafor octahydrochloride
T1776L
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting ...
TC14012 acetate
TP2112L
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent C...
Motixafortide TFA(664334-36-5,Free)
T14665L
Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL...
SB225002
T1955
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
MSX-122
T3992
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
ATI-2341 acetate(1337878-62-2 free base)
T6764L
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. ATI-2341 acetate activates inhibitory heterotrimeric G protein (G...
Reparixin L-lysine salt
T12705
Reparixin L-lysine salt (Repertaxin L-lysine salt) is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
LY2510924 acetate(1088715-84-7 free base)
T15805L
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.
SB-265610
T16850
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calciu...
rac-NBI-74330
T26035
rac-NBI-74330 is an effective and selective CXCR3 antagonist.
Plerixafor
T1776
Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
Danirixin
T5193
Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
IT1t dihydrochloride
T11693L
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
NUCC-390
T12269
NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100. This compou...
Ac-Pro-Gly-Pro-OH
T76662
Ac-Pro-Gly-Pro-OH is an acetyl-modified tripeptide compound that acts as a CXCR2 agonist.Ac-Pro-Gly-Pro-OH exhibits bactericidal and anti-inflammatory activity, ...
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