Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).
説明 | SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively). |
ターゲット&IC50 | CXCR2 (CINC-1-induced calcium mobilization):3.7 nM, CXCR2 (neutrophil chemotaxis):70 nM |
In vitro | SB-265610 decreases the antiapoptotic effect of CINC-1 to the levels of those untreated with CINC-1. SB-265610 antagonizes rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization (IC50 of 3.7 nM) and rat neutrophil chemotaxis in a concentration-dependent manner (IC50 of 70 nM) [1]. |
In vivo | SB-265610 (100 mg/kg/day;p.o; daily; for 5 days; CXCR2 wild type mice) treatment markedly delays healing parameters in CXCR2 wild type mice during the wound repair process[2]. |
別名 | GSK-CXCR2 |
分子量 | 357.16 |
分子式 | C14H9BrN6O |
CAS No. | 211096-49-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 66 mg/mL (184.79 mM)
You can also refer to dose conversion for different animals. 詳細
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SB-265610 211096-49-0 Autophagy GPCR/G Protein Immunology/Inflammation CXCR nonpeptide inhibit Inhibitor inflammation recruitment SB 265610 Delay healing neutrophil wound CXC chemokine receptors GSK-CXCR2 SB265610 inhibitor