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JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .
Cat. No. 製品名 CAS No. Purity Chemical Structure
T2S1040 Jolkinolide B 37905-08-1 98%
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T6784 BI-78D3 883065-90-5 98%
BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
TN1403 Arjunolic acid 465-00-9 98%
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
T8661 AS601245.2TFA (345987-15-7 free base) 345987-16-8 98%
AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectivel...
T77694 JNK-IN-13 345986-38-1 98%
JNK-IN-13 is a selective and potent JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders....
T60534 JNK-IN-11 676594-38-0 98%
JNK-IN-11 is a potent JNK inhibitor that inhibits JNK1, JNK2, and JNK3 with IC50 values of 1.8, 21.4, and 2.2 µM, respectively.JNK-IN-11 can be used to study abn...
T3200 DB07268 929007-72-7
DB07268 is a potent and selective JNK1 inhibitor.
T8477 IQ-3 312538-03-7
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in ...
TN3967 Epieriocalyxin A 191545-24-1
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
TN1448 (-)-Bornyl acetate 5655-61-8
(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal...
T9688 CC-90001 1403859-14-2
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
T2234 TCS JNK 5a 312917-14-9
TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
T7190 Actein 18642-44-9
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
T3S0209 Vincristine 57-22-7 100%
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
TP1897L1 JIP-1 (153-163) acetate(438567-88-5 free base) 100%
JIP-1 (153-163) acetate(438567-88-5 free base) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (J...
T2675 Bentamapimod 848344-36-5 95.21%
Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.
T13018 SU3327 40045-50-9 97.13%
SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
T73182 BSJ-04-122 2513289-74-0 97.58%
BSJ-04-122 is a covalent MKK4/7 dual inhibitor that inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively.BSJ-04-122 can be used for cancer re...
T5094 IRAK inhibitor 1 1042224-63-4 97.78%
IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
T3627 IQ-1S free acid 23146-22-7 97.82%
IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inf...
Jolkinolide B
T2S1040
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
BI-78D3
T6784
BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
Arjunolic acid
TN1403
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
AS601245.2TFA (345987-15-7 free base)
T8661
AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectivel...
JNK-IN-13
T77694
JNK-IN-13 is a selective and potent JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders....
JNK-IN-11
T60534
JNK-IN-11 is a potent JNK inhibitor that inhibits JNK1, JNK2, and JNK3 with IC50 values of 1.8, 21.4, and 2.2 µM, respectively.JNK-IN-11 can be used to study abn...
DB07268
T3200
DB07268 is a potent and selective JNK1 inhibitor.
IQ-3
T8477
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in ...
Epieriocalyxin A
TN3967
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
(-)-Bornyl acetate
TN1448
(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal...
CC-90001
T9688
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
TCS JNK 5a
T2234
TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
Actein
T7190
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
Vincristine
T3S0209
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
JIP-1 (153-163) acetate(438567-88-5 free base)
TP1897L1
JIP-1 (153-163) acetate(438567-88-5 free base) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (J...
Bentamapimod
T2675
Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.
SU3327
T13018
SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
BSJ-04-122
T73182
BSJ-04-122 is a covalent MKK4/7 dual inhibitor that inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively.BSJ-04-122 can be used for cancer re...
IRAK inhibitor 1
T5094
IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
IQ-1S free acid
T3627
IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inf...
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