JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .

Cat. No.	製品名	CAS No.	Purity
TP1897L1	JIP-1 (153-163) acetate(438567-88-5 free base)	TP1897L1	98%
TP1897L1	Peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar ...
T3200	DB07268	929007-72-7	98%
T3200	DB07268 is a potent and selective JNK1 inhibitor.
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T16927	SR-3306	1128096-91-2	98%
T16927	SR-3306 is a potent and highly inhibitor of brain penetrant JNK.
TN3967	Epieriocalyxin A	191545-24-1	98%
TN3967	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
T9688	CC-90001	1403859-14-2	98%
T9688	CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
TN1493	Chrysosplenol D	14965-20-9	98%
TN1493	Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
T2234	TCS JNK 5a	312917-14-9	98%
T2234	TCS JNK 5a is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
TN1403	Arjunolic acid	465-00-9	98%
TN1403	Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
T4S2326	Cornuside	131189-57-6	98%
T4S2326	1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human en...
T8661	AS601245.2TFA (345987-15-7 free base)	345987-16-8	98%
T8661	AS601245.2TFA is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively).
T8477	IQ-3	312538-03-7	98%
T8477	IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in ...
TN1918	Medicarpin	32383-76-9	98%
TN1918	Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of pea...
TN1448	(-)-Bornyl acetate	5655-61-8	98%
TN1448	(-)-Bornyl acetate is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal activity. (-)-Bornyl ...
T7190	Actein	18642-44-9	98%
T7190	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
T3S0209	Vincristine	57-22-7	98%
T3S0209	Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
T6784	BI-78D3	883065-90-5	98%
T6784	BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
T2675	Bentamapimod	848344-36-5	98%
T2675	AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.
T13018	SU3327	40045-50-9	98%
T13018	SU3327 is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
T73182	BSJ-04-122	2513289-74-0	98%
T73182	BSJ-04-122 is a covalent MKK4/7 dual inhibitor that inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively.BSJ-04-122 can be used for cancer re...