|
T10395L |
ATM-3507
|
|
Myosin
|
|
ATM-3507 is a protomyosin inhibitor with anticancer activity that inhibits human melanoma and can be used to study ovarian cancer. |
|
T2685 |
KU-55933
|
ATM Kinase Inhibitor |
ATM/ATR
,
DNA-PK
,
PI3K
,
mTOR
,
Autophagy
|
|
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor. |
|
T62684 |
Lartesertib
|
ATM Inhibitor-5,M4076 |
ATM/ATR
|
|
Lartesertib (ATM Inhibitor-5) is an inhibitor of serine/threonine protein kinase ATM with potential anticancer activity for the study of lung cancer. |
|
T70113 |
ATM-1001
|
|
|
|
ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets. |
|
T10395 |
ATM-3507 trihydrochloride (1861449-70-8 free base)
|
ATM-3507 trihydrochloride |
Others
|
|
ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines). |
|
T10396 |
ATM Inhibitor-1
|
|
ATM/ATR
|
|
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50,... |
|
T63714 |
ATM-IN-1
|
|
|
|
ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases. |
|
T79306 |
ATM Inhibitor-9
|
|
ATM/ATR
|
|
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1]. |
|
T79305 |
ATM Inhibitor-8
|
|
ATM/ATR
|
|
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of 1.15 nM. |
|
T63279 |
ATM Inhibitor-2
|
|
|
|
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM). |
|
T63317 |
ATM Inhibitor-4
|
|
|
|
ATM Inhibitor -4 is a selective and potent ATM inhibitor (IC50: 0.32 nM) that strongly inhibits the activity of the PI3K kinase family and exhibits good metabolic stability. ATM Inhibitor -4 completely inhibits mTOR at 1... |
|
T63171 |
ATM Inhibitor-3
|
|
|
|
ATM Inhibitor-3 is a potent and selective inhibitor of ATM (IC50: 0.71 nM). ATM Inhibitor-3 inhibits the PI3K kinase family and exhibits good metabolic stability. |
|
T72218 |
ATM-3507 trihydrochloride
|
|
|
|
ATM-3507 trihydrochloride, a potent inhibitor of tropomyosin, demonstrates inhibition concentration (IC50) values ranging from 3.83 to 6.84 μM across various human melanoma cell lines. |
|
T5175 |
Azd1390
|
|
ATM/ATR
|
|
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes. |
|
T3338 |
Ceralasertib
|
AZD6738 |
ATM/ATR
|
|
Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. |
|
T4443 |
AZ32
|
|
ATM/ATR
|
|
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. |
|
T1958 |
AZ20
|
|
ATM/ATR
,
mTOR
|
|
AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR. |
|
T6770 |
AZD0156
|
|
Apoptosis
,
ATM/ATR
|
|
AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing. |
|
T1821 |
CGK733
|
CGK 733 |
ATM/ATR
|
|
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR. |
|
T6261 |
CP-466722
|
CP 466722,CP466722 |
ATM/ATR
|
|
CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells. |
|
T3032 |
VE-821
|
ATR Inhibitor IV |
ATM/ATR
|
|
VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays). |
|
T2084 |
ETP-46464
|
|
ATM/ATR
,
DNA-PK
,
PI3K
,
mTOR
|
|
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM). |
|
T6612 |
NU6027
|
|
ATM/ATR
,
DNA-PK
,
CDK
|
|
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors. |
|
T7318 |
Elimusertib
|
BAY-1895344 |
ATM/ATR
|
|
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target... |
|
T7122 |
AZD-7648
|
|
DNA-PK
|
|
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity. |
|
T5092 |
AIM-100
|
AIM100 |
ACK
|
|
AIM-100 is a Ack1 inhibitor (IC50: 24 nM). |
|
T1923 |
BRD4770
|
|
Histone Methyltransferase
|
|
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence. |
|
T70112 |
GT-2227
|
|
|
|
GT-2227 is a histamine H3 receptor antagonist. |
|
T13238 |
Tyrphostin AG1433
|
SU1433,AG1433 |
VEGFR
,
PDGFR
|
|
|
|
T19671 |
AZ31
|
AZ 31,AZ-31 |
ATM/ATR
|
|
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK f... |
|
T2474 |
KU60019
|
KU-60019,KU 60019 |
ATM/ATR
|
|
Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases. |
|
T70873 |
M3541
|
|
Apoptosis
,
ATM/ATR
|
|
M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage che... |
|
T63872 |
KU-60019
|
|
ATM/ATR
|
|
KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM). |
|
T6100 |
Torin 2
|
|
Apoptosis
,
ATM/ATR
,
DNA-PK
,
mTOR
,
Autophagy
|
|
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2... |
|
T16773 |
Ro 90-7501
|
RO-90-7501 |
Apoptosis
,
Phosphatase
,
ATM/ATR
,
Gamma-secretase
|
|
Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest... |
|
T62083 |
Camonsertib
|
ATR inhibitor 4,RP-3500 |
ATM/ATR
|
|
Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR... |
|
T2433 |
NU 7026
|
NU7026,DNA-PK Inhibitor II,LY293646 |
Apoptosis
,
ATM/ATR
,
DNA-PK
,
PI3K
|
|
NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR. |
|
T15673 |
KU 59403
|
|
ATM/ATR
|
|
KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively). |
|
T6283 |
Wortmannin
|
SL-2052,KY-12420 |
ATM/ATR
,
DNA-PK
,
Serine/threonin kinase
,
PLK
,
PI3K
,
Antibiotic
,
Autophagy
|
|
Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy. |
|
T78711 |
A011
|
|
ATM/ATR
|
|
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumo... |
|
T35942 |
AZ 5704
|
|
|
|
Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Pot... |
|
T39523 |
Antitumor agent-28
|
|
|
|
Antitumor agent-28 is a compound that specifically targets and inhibits the activity of the ataxia telangiectasia mutated (ATM) kinase. By doing so, it effectively impedes the progression of ATM-mediated diseases and dem... |
|
T60273 |
Mirin
|
|
|
|
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC 50 =12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activi... |
|
T68845 |
Americanin A
|
|
|
|
Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells. |
|
T73301 |
ATR-IN-20
|
|
|
|
ATR-IN-20, a potent ATM/ATR inhibitor, showcases an IC50 value of 3 nM. It also exhibits inhibitory activity against mTOR with an IC50 of 18 nM, while maintaining selectivity over PI3Kα (100 nM), ATM (100 nM), and DNA-PK... |
|
T62290 |
SKLB-197
|
|
|
|
SKLB-197 is able to act on ATR (IC50: 0.013 μM), but has little or no activity on the other 402 protein kinases. In vitro and in vivo, SKLB-197 has shown significant antitumour effects against ATM-deficient tumours. |
|
T68870 |
SU-11752
|
|
|
|
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in ... |
|
T36701 |
Phosphoramide mustard (cyclohexanamine)
|
|
|
|
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA d... |
