PI3Kγ | TargetMol

カタログ番号	製品名	別名	ターゲット
T40196	PI3Kγ inhibitor 5
	PI3Kγ inhibitor 5 is a potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ), exhibiting an exceptional IC50 value of 34 nM.
T12465	PI3Kγ inhibitor 2		PI3K
	PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).		PI3K
T12464	PI3Kγ inhibitor 1		PI3K
	PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.		PI3K
T72613	PI3Kγ inhibitor 6
	PI3Kγ Inhibitor 6, a specific inhibitor of PI3Kγ, is utilized in the study of inflammatory and autoimmune diseases.
T79111	PI3Kγ inhibitor 7		PI3K
	PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1]. It also exhibits varying inhibitory effects on other PI3K i...		PI3K
T62165	PI3Kγ inhibitor 4
	PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM). PI3Kγ inhibitor 4 is ~7-fold more selective for PI3Kγ than the α subtype, 43-fold more selective than the β subtype and 18-fold more ...
T14214	AMG 511		PI3K
	AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG...		PI3K
T7879	TASP0415914		Akt , PI3K
	TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T		Akt , PI3K
T21938	AS-041164		PI3K
	AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory e...		PI3K
T6704	TG 100713	TG100713	PI3K
	TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.		PI3K
T22339	GNE-490		Others , PI3K
	GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM).		Others , PI3K
T6208	AS-252424		Casein Kinase , PI3K
	AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.		Casein Kinase , PI3K
T2672	TG100-115		PI3K
	TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.		PI3K
T6394	AS-604850		PI3K
	AS-604850 is a specific and ATP-competitive PI3Kγ inhibitor (IC50: 250 nM), 18-fold more selective for PI3Kγ than PI3Kα, and over 80-fold selectivity for PI3Kγ than PI3Kδ/β.		PI3K
T2248	AS-605240	AS 605240	PI3K , Autophagy
	AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).		PI3K , Autophagy
T6433	CAY10505		Apoptosis , PI3K
	CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).		Apoptosis , PI3K
T6799	IITZ-01		Apoptosis , PI3K , Autophagy
	IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)		Apoptosis , PI3K , Autophagy
T5432	Eganelisib	IPI-549	PI3K
	Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)		PI3K
T7166	GNE-493		PI3K , mTOR
	GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.		PI3K , mTOR
T13119	Tenalisib	RP6530	PI3K
	Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)		PI3K
T64392	PI3K-IN-46		PI3K
	PI3K-IN-46 is a specific inhibitor of PI3Kγ.		PI3K
T6731	WYE-354		Apoptosis , PI3K , mTOR , Autophagy
	WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ ...		Apoptosis , PI3K , mTOR , Autophagy
T12459	PI3K/mTOR Inhibitor-2		PI3K , mTOR
			PI3K , mTOR
T6557	KU-0060648	KU0060648	DNA-PK , PI3K , mTOR
	KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.		DNA-PK , PI3K , mTOR
T6732	WYE-687		p38 MAPK , PI3K , Src , mTOR
	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fol...		p38 MAPK , PI3K , Src , mTOR
T1949	CZC24832		PI3K
	CZC24832 is a selective inhibitor of PI 3-kinase γ.		PI3K
T3656	PKI-402		PI3K , mTOR
	PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.		PI3K , mTOR
T3986	SF2523		DNA-PK , Epigenetic Reader Domain , PI3K , mTOR
	SF2523 is a highly selective and potent inhibitor.		DNA-PK , Epigenetic Reader Domain , PI3K , mTOR
T36200	AZD 3147		mTOR
	AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.		mTOR
T12469	PI4KIIIbeta-IN-9		PI3K , PI4K
	PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .		PI3K , PI4K
T6072	BGT226 maleate	BGT226,NVP-BGT226 (maleate),NVP-BGT226	Apoptosis , PI3K , mTOR , Autophagy
	BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .		Apoptosis , PI3K , mTOR , Autophagy
T1916	Apitolisib	RG 7422,GNE 390,GDC-0980	Apoptosis , PI3K , mTOR
	Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce...		Apoptosis , PI3K , mTOR
T14998	Copanlisib dihydrochloride	BAY 80-6946 dihydrochloride	Apoptosis , PI3K , mTOR
	Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Copanlisib dihydrochloride has super...		Apoptosis , PI3K , mTOR
T1970	Gedatolisib	PF-05212384,PKI-587	PI3K , mTOR
	Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway.		PI3K , mTOR
T36083	DS-7423		PI3K , mTOR
	DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser...		PI3K , mTOR
T6730	WAY-600	WAY600	VEGFR , PI3K , Src , mTOR
	WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold...		VEGFR , PI3K , Src , mTOR
T6103	VS-5584	SB2343,VS 5584,VS5584	PI3K , mTOR
	VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.		PI3K , mTOR
T1999	Taselisib	RG-7604,GDC-0032	PI3K , Carbonic Anhydrase
	Taselisib (GDC-0032) is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity.		PI3K , Carbonic Anhydrase
T6168	ZSTK474		PI3K , Autophagy
	PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.		PI3K , Autophagy
T6319	OSI-027	ASP4786,OSI027	DNA-PK , PI3K , mTOR , Autophagy
	OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. Phase 1.		DNA-PK , PI3K , mTOR , Autophagy
T6072L	BGT226	BGT226 free base,NVP-BGT226	PI3K , mTOR , Autophagy
	BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.		PI3K , mTOR , Autophagy
T6773	AZD8186		PI3K
	AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).		PI3K
T10804	CHMFL-PI3KD-317		PI3K , PI4K
	CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, ...		PI3K , PI4K
T2365	Pilaralisib	SAR245408,XL-147	PI3K
	Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials studying the treatment of Cancer, Lymphoma, Solid...		PI3K
T2616	PIK-93	PIK 93	ATM/ATR , DNA-PK , Virus Protease , PI3K , Carbonic Anhydrase , PI4K , mTOR , HSV
	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T6883	Samotolisib	GTPL8918,LY3023414	DNA-PK , PI3K , mTOR , Autophagy
	Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, ...		DNA-PK , PI3K , mTOR , Autophagy
T25399	ETP-45658	ETP45658,ETP 45658	DNA-PK , PI3K , mTOR
	ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively...		DNA-PK , PI3K , mTOR
T6322	Copanlisib	BAY 80-6946	Apoptosis , PI3K
	Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor c...		Apoptosis , PI3K
T2265	Bimiralisib	5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2	Others , PI3K , S6 Kinase , mTOR
	Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to ...		Others , PI3K , S6 Kinase , mTOR
TQ0313	NVP-BAG956	BAG956	PI3K
	NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).		PI3K

Compounds

PI3Kγ inhibitor 5

T40196

Target: Casein Kinase, PI3K

Target: PI3K, Autophagy

CAY10505

T6433

Synonym:

Target: Apoptosis, PI3K

IITZ-01

T6799

Synonym:

Target: Apoptosis, PI3K, Autophagy

Target: Apoptosis, PI3K, mTOR, Autophagy

PI3K/mTOR Inhibitor-2

Target: DNA-PK, PI3K, mTOR

WYE-687

T6732

Synonym:

Target: p38 MAPK, PI3K, Src, mTOR

Target: DNA-PK, Epigenetic Reader Domain, PI3K, mTOR

Synonym: BGT226,NVP-BGT226 (maleate),NVP-BGT226

Target: Apoptosis, PI3K, mTOR, Autophagy

Apitolisib

T1916

Synonym: RG 7422,GNE 390,GDC-0980

Target: Apoptosis, PI3K, mTOR

Copanlisib dihydrochloride

T14998

Synonym: BAY 80-6946 dihydrochloride

Target: Apoptosis, PI3K, mTOR

Gedatolisib

T1970

Synonym: PF-05212384,PKI-587

Target: VEGFR, PI3K, Src, mTOR

VS-5584

T6103

Synonym: SB2343,VS 5584,VS5584

Target: PI3K, mTOR

Taselisib

T1999

Synonym: RG-7604,GDC-0032

Target: PI3K, Carbonic Anhydrase

ZSTK474

T6168

Synonym:

Target: PI3K, Autophagy

OSI-027

T6319

Synonym: ASP4786,OSI027

Target: DNA-PK, PI3K, mTOR, Autophagy

BGT226

T6072L

Synonym: BGT226 free base,NVP-BGT226

Target: PI3K, mTOR, Autophagy

Synonym: SAR245408,XL-147

Target: ATM/ATR, DNA-PK, Virus Protease, PI3K, Carbonic Anhydrase, PI4K, mTOR, HSV

Samotolisib

T6883

Synonym: GTPL8918,LY3023414

Target: DNA-PK, PI3K, mTOR, Autophagy

ETP-45658

T25399

Synonym: ETP45658,ETP 45658

Target: DNA-PK, PI3K, mTOR

Copanlisib

T6322

Synonym: BAY 80-6946

Target: Apoptosis, PI3K

Bimiralisib

T2265

Synonym: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2

Target: Others, PI3K, S6 Kinase, mTOR

カタログ番号	製品名	別名	ターゲット
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
T1879	3-Methyladenine	3-MA,NSC 66389	Mitophagy , PI3K , Endogenous Metabolite , Autophagy
	3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy.		Mitophagy , PI3K , Endogenous Metabolite , Autophagy
T2174	Quercetin	Sophoretin	Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy
	Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.
T3040	Gallein	Pyrogallolphthalein,Mordant violet 25,Alizarin violet	Others
	Gallein (Mordant violet 25) is a small molecule inhibitor of Gβγ activity.		Others
T0579	Myricetin	Cannabiscetin	Apoptosis , PI3K , Endogenous Metabolite , Autophagy
	Myricetin (Cannabiscetin) is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source. It has been shown that myricetin has anti...		Apoptosis , PI3K , Endogenous Metabolite , Autophagy
T6630	Quercetin Dihydrate	Sophoretin	Apoptosis , PI3K
	Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effect...		Apoptosis , PI3K

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Compounds

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