PI3Kα | TargetMol

カタログ番号	製品名	別名	ターゲット
T12589	PI3Kα/mTOR-IN-1		PI3K , mTOR
	PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively.		PI3K , mTOR
T35527	PI3Kα-IN-4	PI3Kα-IN-4
	PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1].
T35488	(S)-PI3Kα-IN-4	(S)-PI3Kα-IN-4
	(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the...
T16529	BEBT-908	PI3Kα inhibitor 1,MDK9521	PI3K , HDAC
	BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).		PI3K , HDAC
T9312	PI3Kα Inhibitor 7
	PI3Kα Inhibitor 7 is a useful organic compound for research related to life sciences. The catalog number is T9312 and the CAS number is 1239978-63-2.
T62073	PI3Kα-IN-6
	PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor that exhibits anticancer effects without toxicity to normal cells. PI3Kα-IN-6 increases ROS production, decreases mitochondrial membrane potential and induces apoptosis.
T61654	PI3Kα-IN-9
	PI3Kα-IN-9 (compound 27) is a highly specific, orally active, and long-lasting inhibitor of PI3Kα, demonstrating potent inhibitory effects with IC50 values of 4.4, 128, 146, and 153 nM against PI3Kα, PI3Kγ, PI3Kδ, and PI...
T61967	PI3Kα-IN-7
	PI3Kα-IN-7 (Compound A12) is a potent PI3Kα inhibitor, and also inhibits PI3Kβ. PI3Kα-IN-7 can reduce cancer cells mitochondrial membrane potential and induce apoptosis.
T78804	PI3Kα-IN-12		PI3K
	PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values of 0.83 and 1.25 μM, respectively. Intraperitoneal administr...		PI3K
T81469	PI3Kα-IN-14		PI3K
	PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in cell cycle arrest at the G1 phase and apoptosis in U87-MG cel...		PI3K
T63477	PI3Kα-IN-8
	PI3Kα-IN-8 is a selective inhibitor of PI3Kα (IC50: 0.012 μM). PI3Kα-IN-8 increases intracellular levels of reactive oxygen species, decreases mitochondrial membrane potential, and induces apoptosis.
T79685	PI3Kα-IN-13		PI3K
	PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, exhibiting IC50 values of 0.75 μM (MCF-7), 3.79 μM (HCT-116)...		PI3K
T79710	PI3Kα/HDAC6-IN-1		HDAC
	PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively. It effectively hinders AKT(Ser473) phosphorylation and promotes the build-up of acetylated...		HDAC
T14214	AMG 511		PI3K
	AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG...		PI3K
T6704	TG 100713	TG100713	PI3K
	TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.		PI3K
T22339	GNE-490		Others , PI3K
	GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM).		Others , PI3K
T2256	CNX-1351		PI3K
	CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.		PI3K
T67704	MTOR inhibitor 9e		PI3K , mTOR
	mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.		PI3K , mTOR
T67706	MTOR inhibitor 9c		PI3K , mTOR
	mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.		PI3K , mTOR
T2308	HS-173	HS 173,HS173	Apoptosis , PI3K
	HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).		Apoptosis , PI3K
T15375	Inavolisib	GDC-0077,RG6114	Apoptosis , PI3K
	Inavolisib (GDC-0077) is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib exerts its activity by binding to the ATP binding ...		Apoptosis , PI3K
T9310	MTOR inhibitor 13		PI3K , mTOR
	mTOR inhibitor 13 is a selective mTOR inhibitor with IC50 of 0.29nM and 119nM for mTOR and PI3Kα, respectively.		PI3K , mTOR
T67701	MTOR inhibitor 9f		PI3K , mTOR
	mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.		PI3K , mTOR
TQ0229	ETP-46321		PI3K
	ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).		PI3K
T6774	AZD-8835	AZD8835	PI3K
	AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).		PI3K
T6072	BGT226 maleate	BGT226,NVP-BGT226 (maleate),NVP-BGT226	Apoptosis , PI3K , mTOR , Autophagy
	BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .		Apoptosis , PI3K , mTOR , Autophagy
T16355	NSC781406		PI3K , mTOR
	NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).		PI3K , mTOR
T2377	Pilaralisib analogue	XL147 analogue,SAR245408	Apoptosis , DNA-PK , PI3K
	Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.		Apoptosis , DNA-PK , PI3K
T2616	PIK-93	PIK 93	ATM/ATR , DNA-PK , Virus Protease , PI3K , Carbonic Anhydrase , PI4K , mTOR , HSV
	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T1970	Gedatolisib	PF-05212384,PKI-587	PI3K , mTOR
	Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway.		PI3K , mTOR
T6557	KU-0060648	KU0060648	DNA-PK , PI3K , mTOR
	KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.		DNA-PK , PI3K , mTOR
T12310	ON 146040	ZINC211117138	PI3K , Bcr-Abl
			PI3K , Bcr-Abl
T4079	LY-294002 hydrochloride	SF 1101,LY 294002,NSC 697286	PI3K
	LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation...		PI3K
T7166	GNE-493		PI3K , mTOR
	GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.		PI3K , mTOR
T6731	WYE-354		Apoptosis , PI3K , mTOR , Autophagy
	WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ ...		Apoptosis , PI3K , mTOR , Autophagy
T12459	PI3K/mTOR Inhibitor-2		PI3K , mTOR
			PI3K , mTOR
T21938	AS-041164		PI3K
	AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory e...		PI3K
T9788	SN32976		PI3K
	SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.		PI3K
T2672	TG100-115		PI3K
	TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.		PI3K
T3656	PKI-402		PI3K , mTOR
	PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.		PI3K , mTOR
T6510	GDC-0349	RG-7603	PI3K , mTOR , Autophagy
	GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.		PI3K , mTOR , Autophagy
T62083	Camonsertib	ATR inhibitor 4,RP-3500	ATM/ATR
	Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR...		ATM/ATR
T6208	AS-252424		Casein Kinase , PI3K
	AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.		Casein Kinase , PI3K
T11381	Pictilisib dimethanesulfonate	GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
T9315	MTOR kinase Inhibitor 2		Others
	2H-Imidazo[4,5-b]pyrazin-2-one, 1,3-dihydro-6-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(tetrahydro-2H-pyran-4-yl)methyl]- is a potent mTOR inhibitor with IC50 of 0.176 μM and >30 μM for mTOR and PI3Kα, respectively.		Others
T78211	STX-478		PI3K
	STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumor regression, making it a valuable agent in cancer research [1].		PI3K
T14511	BAY1082439		Apoptosis , PI3K
	BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2]. Additionally, BAY1082439 is effective against mutated forms o...		Apoptosis , PI3K
T36083	DS-7423		PI3K , mTOR
	DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser...		PI3K , mTOR
T6732	WYE-687		p38 MAPK , PI3K , Src , mTOR
	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fol...		p38 MAPK , PI3K , Src , mTOR
T36200	AZD 3147		mTOR
	AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively.		mTOR

Compounds

PI3Kα/mTOR-IN-1

T12589

Synonym: (S)-PI3Kα-IN-4

Target:

BEBT-908

T16529

Synonym: PI3Kα inhibitor 1,MDK9521

Synonym: HS 173,HS173

Target: Apoptosis, PI3K

Inavolisib

T15375

Synonym: GDC-0077,RG6114

Target: Apoptosis, PI3K

Synonym: BGT226,NVP-BGT226 (maleate),NVP-BGT226

Target: Apoptosis, PI3K, mTOR, Autophagy

Synonym: XL147 analogue,SAR245408

Target: Apoptosis, DNA-PK, PI3K

PIK-93

T2616

Synonym: PIK 93

Target: ATM/ATR, DNA-PK, Virus Protease, PI3K, Carbonic Anhydrase, PI4K, mTOR, HSV

Gedatolisib

T1970

Synonym: PF-05212384,PKI-587

Target: DNA-PK, PI3K, mTOR

ON 146040

T12310

Synonym: ZINC211117138

Target: PI3K, Bcr-Abl

LY-294002 hydrochloride

T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: Apoptosis, PI3K, mTOR, Autophagy

PI3K/mTOR Inhibitor-2

Target: PI3K, mTOR, Autophagy

Camonsertib

T62083

Synonym: ATR inhibitor 4,RP-3500

Target: Casein Kinase, PI3K

Pictilisib dimethanesulfonate

T11381

Synonym: GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

mTOR kinase Inhibitor 2

Target: Apoptosis, PI3K

Target: p38 MAPK, PI3K, Src, mTOR

カタログ番号	製品名	別名	ターゲット
T3208	Brevianamide F	Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)	BCRP , PI3K , Antibacterial
	Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F possess interesting breast cancer resistance protein inhibitory acti...		BCRP , PI3K , Antibacterial

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ターゲット

阻害剤

天然化合物

Compounds

天然物製品