Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 40,500 | |||
50 mg | 在庫あり | ¥ 68,500 | |||
100 mg | 在庫あり | ¥ 102,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator. |
In vivo | AZD7325 on synaptic responses was more prominent in mice on the 129S6/SvEvTac background strain that has been demonstrated to be seizure resistant in the model of Dravet syndrome (Scn1a+/?) and in which the α2 GABAA receptor subunits are higher relative to in the C57BL/6J strain.?Consistent with this, treatment of mice with AZD7325 is associated with a higher temperature threshold for hyperthermia-induced seizures in Scn1a+/? mice without apparent sedative effects.?Our results in a model system indicate that selective targeting α2 is a potential therapeutic option for Dravet syndrome[1]. |
動物実験 | Animal Model:Male and female P18 - P20 F1.Scn1a+/- mice. Dosage:10, 17.8 or 31.6 mg/kg. Administration:Oral administration[1] |
別名 | AZD-7325 |
分子量 | 354.38 |
分子式 | C19H19FN4O2 |
CAS No. | 942437-37-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (25.4 mM)
You can also refer to dose conversion for different animals. 詳細
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AZD7325 942437-37-8 Membrane transporter/Ion channel Metabolism Neuroscience GABA Receptor P450 modulator effect inhibit Cytochrome P450 Dravet syndrome Inhibitor γ-Aminobutyric acid Receptor CYPs sedative AZD 7325 PAM CYP1A2 Gamma-aminobutyric acid Receptor anxiety AZD-7325 inhibitor