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271

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T37075	CB2R PAM	Ec2la	Cannabinoid Receptor
	CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive mutational modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors, but has no effect in the abs...		Cannabinoid Receptor
T37428	TRPC6-PAM-C20	TRPC6-PAM-C20,3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one	TRP/TRPV Channel
	TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced p...		TRP/TRPV Channel
T1111	Pralidoxime Chloride	2-PAM chloride,2-Pyridinealdoxime methochloride,2-PAM (chloride)	AChE
	Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates o...		AChE
T33872	Pam 1392	AI3 52841,AI352841,AI3-52841
	Pam 1392 is a chemotherapeutic agent.
T22404	Pralidoxime Iodide	2-PAM	Others
	Pralidoxime Iodide, also named 2-PAM, is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.		Others
TP2399	Palmitoyl tetrapeptide	Pam-ser-ser-asn-ala
	Palmitoyl tetrapeptide is an analog of the N-terminal part of lipoprotein from the outer membrane of E. coli.
T9177	BPAM344		iGluR
	BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.		iGluR
T23514	VU-1545	VU 1545	GluR
	VU-1545 is mGlu5 positive allosteric modulator.		GluR
T29123	VU0152099	VU 0152099,VU-0152099	AChR
	VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).		AChR
T8991	BMS986187		Opioid Receptor
	BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.		Opioid Receptor
T9021	Ro0711401	Ro-0711401,Ro 0711401	GluR
	Ro0711401 is an agonist of mGlu1 receptor.		GluR
T28069	ML380	ML 380,ML-380	AChR
	ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).		AChR
TP1962	Pam2CSK4
	Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.
T29137	VU0453595	VU 0453595,VU-0453595	AChR
	VU0453595 is a M1 positive allosteric modulator (PAM).		AChR
T7699	AZD7325	AZD-7325	P450 , GABA Receptor
	AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.		P450 , GABA Receptor
TP2282	Pam2CSK4 Biotin		Others
	biotinylated Pam2CSK4, a toll-like receptor 2/6 agonist		Others
T70460	HM5023507
	HM5023507, an orally active dual inhibitor of δγ isoforms in immune signaling. HM5023507 inhibited PI3Kδ and PI3Kγ isoforms with greater than 100-fold selectivity against PI3Kα and PI3Kβ in recombinant enzymatic assays a...
TP1067	Pam3CSK4 TFA (112208-00-1 free base)	Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA	TLR
	Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).		TLR
TP1068	Pam3CSK4	Pam3Cys-Ser-(Lys)4
	Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.
T60047	V-0219		Glucagon Receptor
	V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.		Glucagon Receptor
TP1066	Pam3CSK4-Biotin	Pam3Cys-Ser-(Lys)4-Biotin
	Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.
T34896	Tofisopam	Emandaxin,Grandaxin	Others
	Tofisopam (Grandaxin) is a 2,3-benzodiazepine compound with anxiolytic activity that can be taken orally.		Others
T11353	Gallopamil	Methoxyverapamil	Calcium Channel
			Calcium Channel
T16431	Pamatolol		Adrenergic Receptor
			Adrenergic Receptor
T6638	Retapamulin	SB-275833	ribosome , Antibacterial , Antibiotic
	Retapamulin (SB-275833), a Pleuromutilin Antibacterial, binds to both E. coli and S. aureus ribosomes with similar potencies (Kd: 3 nM).		ribosome , Antibacterial , Antibiotic
T15645	Pamicogrel	KBT3022	COX
	Pamicogrel (KBT3022) is an inhibitor of COX.		COX
T0490	Chlorpropamide	Diabinese	ATPase , ABC
	Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.		ATPase , ABC
T6835	Fenoldopam mesylate	Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526	Dopamine Receptor
	Fenoldopam mesylate (Corlopam mesylate) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.		Dopamine Receptor
T7333	Pyrvinium pamoate	Pyrvinium embonate	Wnt/beta-catenin
	Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types ...		Wnt/beta-catenin
T68081	Girisopam
	Girisopam is a novel selective benzodiazepine analog for the 2,3-benzodiazepine binding site, an atypical psychoanalytic with anxiolytic effects.
T1010	Verapamil hydrochloride	Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450 , Calcium Channel , P-gp
	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.		P450 , Calcium Channel , P-gp
T7809L	Ipamorelin 2 Pivalic acid	NNC-26-0161	Others
	Ipamorelin 2 Pivalic acid (NNC-26-0161) is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats.		Others
T12480	Pipamperone	Floropipamide,McN-JR 3345,R 3345	Others , Dopamine Receptor , 5-HT Receptor
	Pipamperone (McN-JR 3345) binds 5-HT2A closely as receptor.		Others , Dopamine Receptor , 5-HT Receptor
T11353L	Gallopamil hydrochloride	Methoxyverapamil hydrochloride	Calcium Channel
			Calcium Channel
T27275L	Epaminurad HCl（1198153-15-9 Free base）

T60075	Dopamine D2 receptor agonist-2	Dopamine D2 Receptor	Dopamine Receptor
	Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) is a ligand targeting the dopamine D2 receptor.		Dopamine Receptor
T68076L	Fosopamine(HCl)		Dopamine Receptor
	Fosopamine(HCl) is a DRDs agonist that can be used to study hypertension.		Dopamine Receptor
T28164	Nexopamil	LU49938,LU 49938,LU-49938	Calcium Channel , 5-HT Receptor
	Nexopamil (LU-49938) is a calcium channel antagonist and a 5-hydroxytryptamine 2A receptor antagonist. Nexopamil inhibits 5-HT-induced contraction and proliferation of mesenchymal cells.		Calcium Channel , 5-HT Receptor
T16339	Norverapamil hydrochloride	(±)-Norverapamil hydrochloride,D591 hydrochloride	Calcium Channel , P-gp , Drug Metabolite
	Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.		Calcium Channel , P-gp , Drug Metabolite
T17266	Xipamide	Diurexan,Aquaphor	Others
	Xipamide (Diurexan) is a sulfonamide-based diuretic with antihypertensive properties. Xipamide selectively inhibits anion exchanger.		Others
T0271	Iodipamide	Iodipamic acid,Adipiodone	Others
	Iodipamide (Iodipamic acid) is a water-soluble radiographic contrast media for intravenous cholangiography and cholecystography.		Others
T6927	Pamapimod	R1503,Ro4402257	p38 MAPK , Autophagy
	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv...		p38 MAPK , Autophagy
T12352L	Oxidopamine hydrobromide	6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T7809	Ipamorelin	NNC-26-0161	Others
	Ipamorelin (NNC-26-0161) is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats.		Others
T13257	Upamostat		PAI-1 , Serine/threonin kinase , Serine Protease
	Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.		PAI-1 , Serine/threonin kinase , Serine Protease
T8400	Pamidronic acid		Wnt/beta-catenin
	Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells		Wnt/beta-catenin
T1259	Pyrantel pamoate	Pyrantel embonate	Others , Antibiotic , Parasite
	Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent.		Others , Antibiotic , Parasite
T13512	5-Hydroxydopamine hydrochloride		Antifungal
	5-Hydroxydopamine hydrochloride is a naturally occurring amine in human urine with an IC50 value of 22 µM for the Luxaphone receptor.5-Hydroxydopamine has potential antimicrobial and anticancer activities.5-Hydroxydopami...		Antifungal
T0323	Oxantel Pamoate	Oxantel embonate	Others , Parasite
	Oxantel Pamoate (Oxantel embonate) is used as an Antinematodal agent.		Others , Parasite
TP1880L1	PAMP-12 (human, porcine) acetate	PAMP-12 (human, porcine) acetate(196305-05-2 free base)	Others
	PAMP-12 (human, porcine) acetate (PAMP-12 (human, porcine) acetate (196305-05-2 free base)) , a major component of ir-PAMP, is processed from the AM precursor, as is PAMP-20, and may participate in cardiovascular control...		Others

Compounds

CB2R PAM

T37075

Synonym: Ec2la

Target: Cannabinoid Receptor

TRPC6-PAM-C20

T37428

Synonym: TRPC6-PAM-C20,3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one

Target: TRP/TRPV Channel

Pralidoxime Chloride

T1111

Synonym: 2-PAM chloride,2-Pyridinealdoxime methochloride,2-PAM (chloride)

Target: AChE

Pam 1392

T33872

Synonym: AI3 52841,AI352841,AI3-52841

Palmitoyl tetrapeptide

TP2399

Synonym: Pam-ser-ser-asn-ala

Synonym: VU 0152099,VU-0152099

Target: Opioid Receptor

Ro0711401

T9021

Synonym: Ro-0711401,Ro 0711401

Target: GluR

ML380

T28069

Synonym: ML 380,ML-380

Synonym: VU 0453595,VU-0453595

Target: P450, GABA Receptor

Pam3CSK4 TFA (112208-00-1 free base)

TP1067

Synonym: Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA

Target: TLR

Pam3CSK4

TP1068

Synonym: Pam3Cys-Ser-(Lys)4

Target: Glucagon Receptor

Pam3CSK4-Biotin

TP1066

Synonym: Pam3Cys-Ser-(Lys)4-Biotin

Target:

Tofisopam

T34896

Synonym: Emandaxin,Grandaxin

Target: Others

Gallopamil

T11353

Synonym: Methoxyverapamil

Target: Calcium Channel

Pamatolol

T16431

Synonym:

Target: Adrenergic Receptor

Retapamulin

T6638

Synonym: SB-275833

Target: ribosome, Antibacterial, Antibiotic

Synonym: Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526

Target: Dopamine Receptor

Pyrvinium pamoate

T7333

Synonym: Pyrvinium embonate

Target: Wnt/beta-catenin

Verapamil hydrochloride

T1010

Synonym: Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride

Target: P450, Calcium Channel, P-gp

Ipamorelin 2 Pivalic acid

Synonym: Floropipamide,McN-JR 3345,R 3345

Target: Others, Dopamine Receptor, 5-HT Receptor

Gallopamil hydrochloride

T11353L

Synonym: Methoxyverapamil hydrochloride

Target: Calcium Channel

Epaminurad HCl（1198153-15-9 Free base）

T27275L

Synonym:

Target:

Dopamine D2 receptor agonist-2

T60075

Synonym: Dopamine D2 Receptor

Target: Dopamine Receptor

Fosopamine(HCl)

T68076L

Synonym:

Target: Dopamine Receptor

Nexopamil

T28164

Synonym: LU49938,LU 49938,LU-49938

Target: Calcium Channel, 5-HT Receptor

Norverapamil hydrochloride

T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride

Target: Calcium Channel, P-gp, Drug Metabolite

Xipamide

T17266

Synonym: Diurexan,Aquaphor

Target: Others

Iodipamide

T0271

Synonym: Iodipamic acid,Adipiodone

Target: Others

Pamapimod

T6927

Synonym: R1503,Ro4402257

Target: p38 MAPK, Autophagy

Oxidopamine hydrobromide

T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Target: PAI-1, Serine/threonin kinase, Serine Protease

Pamidronic acid

T8400

Synonym:

Target: Wnt/beta-catenin

Pyrantel pamoate

T1259

Synonym: Pyrantel embonate

Target: Others, Antibiotic, Parasite

5-Hydroxydopamine hydrochloride

Synonym: Oxantel embonate

Target: Others, Parasite

PAMP-12 (human, porcine) acetate

TP1880L1

Synonym: PAMP-12 (human, porcine) acetate(196305-05-2 free base)

Target: Others

カタログ番号	製品名	別名	ターゲット
T1644	Dopamine hydrochloride	Dopamine HCl,ASL279	Ferroptosis , Dopamine Receptor , 5-HT Receptor , Endogenous Metabolite
	Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b...
T0469	Octopamine hydrochloride	(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl	Dopamine Receptor , Endogenous Metabolite , Adrenergic Receptor
	Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) is a biogenic monoamine structurally associated with noradrenaline. It can serve as a neurohormone, a neurotransmitter, and a neuromodulator in invertebrates.
T2825	Cyclopamine	11-Deoxojervine	Hedgehog/Smoothened , Endogenous Metabolite , Smo
	Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.		Hedgehog/Smoothened , Endogenous Metabolite , Smo
TN1968	N-Feruloyloctopamine	N-Feruloyloctopamine	p38 MAPK , Akt
	N-Feruloyloctopamine is a natural product.		p38 MAPK , Akt
TN1970	N-trans-p-coumaroyloctopamine	N-p-Coumaroyloctopamine,p-coumaroylnoradrenaline	Others
	N-trans-p-coumaroyloctopamine (p-coumaroylnoradrenaline) is derived from the tuber tissue of potatoes.		Others
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T13108	Pamufetinib	H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115	VEGFR , c-Met/HGFR
	Pamufetinib (TAS-115) is a potent inhibitor of VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase(IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively).		VEGFR , c-Met/HGFR
T73775	Dopamine 3-O-sulfate
	Dopamine 3-O-sulfate, primarily found in plasma, serves as a biomarker for identifying aromatic amino acid decarboxylase (AADC) deficiency [1].
T81710	N-Acetyldopamine dimer-3
	N-Acetyldopamine dimer-3 (Compound 11), a naturally occurring chemical, is present in the species Aspongopus chinensis [1].
T40158	N-acetyldopamine	NADA
	N-acetyldopamine (NADA) is a catecholamine utilized by insects as a precursor for sclerotization, a process that strengthens their cuticle.
TN6456	N-trans-caffeoyloctopamine
	N-trans-Caffeoyltyramine has both arginase inhibitory property and antioxidant capacity.
T25305	Demethoxyrapamycin	AY 24668,AY24668,AY-24668
	Demethoxyrapamycin is a new antifungal antibiotic agent which is co-produced with rapamycin by Streptomyces hygroscopicus.

天然物製品

Dopamine hydrochloride

T1644

Synonym: Dopamine HCl,ASL279

Target: Ferroptosis, Dopamine Receptor, 5-HT Receptor, Endogenous Metabolite

Octopamine hydrochloride

T0469

Synonym: (±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl

Target: Dopamine Receptor, Endogenous Metabolite, Adrenergic Receptor

Cyclopamine

T2825

Synonym: 11-Deoxojervine

Target: Hedgehog/Smoothened, Endogenous Metabolite, Smo

N-Feruloyloctopamine

TN1968

Synonym: N-Feruloyloctopamine

Target: p38 MAPK, Akt

N-trans-p-coumaroyloctopamine

TN1970

Synonym: N-p-Coumaroyloctopamine,p-coumaroylnoradrenaline

Target: Others

Rapamycin

T1537

Synonym: Sirolimus,AY 22989,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Pamufetinib

T13108

Synonym: H2OL3Q4XRD,4-(2-Fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide,TAS-115

Target: VEGFR, c-Met/HGFR

N-Acetyldopamine dimer-3

N-trans-caffeoyloctopamine

Synonym: AY 24668,AY24668,AY-24668

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00392	PAM Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 94.4 kDa and the accession number is P19021-2.
TMPY-00149	PAM Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	PAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 104 kDa and the accession number is P19021-2.
TMPK-00188	JAM-A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor mi...
TMPY-00865	JAM-A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	JAM-A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50 kDa and the accession number is Q9BQB4-1.
TMPY-01035	JAM-A Protein, Human, Recombinant (His)	Human	HEK293 Cells
	JAM-A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Y624-1.
TMPJ-01087	TIM14 Protein, S. cerevisiae, Recombinant	S. cerevisiae	E. coli
	Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner memb...
TMPJ-00965	TIM16 Protein, S. cerevisiae, Recombinant	S. cerevisiae	E. coli
	Mitochondrial import inner membrane translocase subunit TIM16 (TIM16) is an ssential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membr...
TMPH-01509	SPAM1 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyal...
TMPY-03852	Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)	Human	HEK293 Cells
	DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH conta...
TMPH-01690	TIM14 Protein, Human, Recombinant (GST)	Human	E. coli
	Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins...