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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T22994 | ML 154 | Neuropeptide Y Receptor | |
neuropeptide S receptor (NPSR) antagonist | |||
T8318 | BNC210 | H-Ile-Trp-OH,IW-2143 | AChR |
BNC210 (IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression. | |||
T2200 | Hydroxyzine dihydrochloride | Hydroxyzine 2HCl | Histamine Receptor |
Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIR... | |||
T1997 | JNJ-31020028 | JNJ 31020028 | Neuropeptide Y Receptor |
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22, rat); it exhibits >100-fold selectivity for Y2 versus human Y1/Y4/Y5 receptors. | |||
T7061 | Duloxetine | Serotonin Transporter | |
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder. | |||
T5406 | SNAP 94847 | SNAP-94847 | GPR , Melanin-concentrating Hormone Receptor (MCHR) |
SNAP 94847 (SNAP-94847) is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice. | |||
T16421 | P-MPPI hydrochloride | 5-HT Receptor | |
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. | |||
T3183 | SAX-187 | WAY 181187,WAY181187 | 5-HT Receptor |
SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor. | |||
T16472 | Pericyazine | Propericiazine,RP 8909 | Dopamine Receptor |
Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psych... | |||
T6043 | PF-3845 | FAAH , Autophagy | |
PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2. | |||
T9272 | Xaliproden hydrochloride | Dopamine Receptor , 5-HT Receptor | |
Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist. | |||
T8004 | SNAP 94847 hydrochloride | GPR , Melanin-concentrating Hormone Receptor (MCHR) | |
SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM) | |||
T2710 | TCS 1102 | OX Receptor | |
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). | |||
T21011 | Buspirone | Buspirone free base,Ansial | 5-HT Receptor |
Buspirone (Buspirone free base) is an azaspiro compound which has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. | |||
T7644 | DPN | Diarylpropionitrile | Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy |
DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) . | |||
T2067 | NS11394 | NS 11394 | GABA Receptor |
NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors. | |||
T2463 | ML141 | CID-2950007 | Apoptosis , CDK , Ras |
ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM). | |||
T7699 | AZD7325 | AZD-7325 | P450 , GABA Receptor |
AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator. | |||
T21654 | 1-Oleoyl lysophosphatidic acid sodium | 1-Oleoyl lysophosphatidic acid sodium salt | LPA Receptor |
1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2 | |||
T2132 | Buspirone hydrochloride | Buspirone HCl,Narol,Buspar | Dopamine Receptor , 5-HT Receptor |
Buspirone hydrochloride (Buspar) is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD). | |||
T1471 | Duloxetine hydrochloride | Duloxetine HCl,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl | Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine |
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a thiophene derivative and selective neurotransmitter uptake inhibitor for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC and i... | |||
T28197 | NS-2710 | NS2710,NS 2710 | |
NS-2710, a GABA receptor agonist, is used potentially for the treatment of anxiety. | |||
T28537 | Ricasetron | Brl 46470,Brl46470,Brl-46470 | 5-HT Receptor |
Ricasetron (Brl 46470) is a 5-HT3 receptor antagonist with pro-axonal lysis and antiemetic properties, and is used in the study of anxiety and anxiety disorders. | |||
T1696 | 2-(1-Piperazinyl)pyrimidine | Adrenergic Receptor | |
2-(1-Piperazinyl)pyrimidine is used as an anti-anxiety drug. | |||
T28270 | Osemozotan HCl | Osemozotan hydrochloride,MN-305,MCI-242,MKC-242,MKC242,MCI242 | |
Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder. | |||
T32105 | Cipepofol | HSK3486,HSK 3486,HSK-3486 | |
HSK3486 is similar to propofol and is a general anesthetic, which may have therapeutic potential in insomnia, migraine, anxiety, analgesia, and other aspects. | |||
T26559 | ACT-462206 | OX Receptor | |
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studies of sleep and anxiety. | |||
T7136 | AZD-6280 | GABA Receptor | |
AZD6280 is a novel, subtype-selective GABAAα2/3 receptor positive modulators, used for treatment of generalized anxiety disorder. | |||
T25672 | Lesopitron | 5-HT Receptor | |
Lesopitron is an anxiolytic with pre- and postsynaptic 5-HT1A agonist activity and is more effective than 5-HT1A agonists in rat social interaction and marmoset anxiety models. lesopitron counteracts benzodiazepine withd... | |||
T26600 | Alpidem | Ananxyl | GABA Receptor |
Alpidem (Ananxyl) is an anxiolytic drug from the imidazopyridine family. Alpidem does not produce sedative effects at normal doses, and is instead used specifically for the treatment of anxiety. Alpidem has nanomolar bin... | |||
T61816 | EMD 56551 | 5-HT Receptor | |
EMD 56551 is a selective small molecule 5-HT1A receptor agonist with anxiolytic activity for the study of anxiety disorders. | |||
T0715 | Chlormezanone | Trancopal | Others , GABA Receptor |
Chlormezanone (Trancopal) is a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | |||
T0240 | Trimetozine | Sedoxazine,Trioxazin | Others |
Trimetozine (Sedoxazine) is a sedative that has been marketed in Europe since 1959. It has mild tranquilizing effects and has been used to treat anxiety. | |||
T27186 | Divaplon | RU-32698,RU32698,RU 32698 | GABA Receptor |
Divaplon is a GABA receptor agonist (IC50: 0.056 µM) that displays non-sedating anxiolytic behavioral characteristics in a rat model of anxiety. | |||
T23444 | TCS 1105 | N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide | Others |
TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice. | |||
T13110 | Tedatioxetine hydrobromide | Lu AA 24530 hydrobromide | Dopamine Receptor , 5-HT Receptor , Norepinephrine |
Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) is a serotonin-norepinephrine-dopamine reuptake inhibitor and an antagonist of 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors, which can be used to treat depress... | |||
T68172 | Zalospirone | 5-HT Receptor | |
Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder. | |||
T68142 | Serazapine | 5-HT Receptor | |
Serazapine is a highly specific serotonin (5-HT2) binding inhibitor with anxiolytic activity for the treatment of anxiety disorders. | |||
T1077 | Fluvoxamine maleate | MK-264,DU-23000 (maleate) | 5-HT Receptor , Serotonin Transporter |
Fluvoxamine maleate (DU-23000 (maleate)) is a selective serotonin reuptake inhibitor that is used in the treatment of depression and a variety of anxiety disorders. | |||
T27262 | Enciprazine | WY-48624,D-3112,WY48624,WY 48624,D 3112,D3112 | 5-HT Receptor |
Enciprazine (D-3112) has anxiolytic activity with high affinity for 5-HT1A receptor and ADRA1, which can be used for the treatment of anxiety disorders and can be used to study depression. | |||
T67954 | Endixaprine | SR 41378 | |
Endixaprine (SR 41378) is a small molecule compound used to treat neurological disorders and may be used to study anxiety disorders and epilepsy. | |||
T67966 | Triflubazam | ||
Triflubazam has a wide range of biological activities that can affect sleep and can be used to treat anxiety syndromes and psychological disorders. | |||
T68154 | TC-2216 | AChR | |
TC-2216 is a partial agonist at the neural nicotinic acetylcholine receptor and is used to treat anxiety and depression. | |||
T31592 | E6801 | E 6801,E-6801 | 5-HT Receptor |
E6801 is a novel selective 5-HT6 receptor agonist with a wide range of biological activities.E6801 can be used in the study of dementia, Parkinson's disease, depression, obesity epilepsy, anxiety, and many other diseases... | |||
T22442 | Trazodone | AF-1161 | 5-HT Receptor |
Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder. | |||
T90597 | SSR504734 HCl | ||
SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 ( IC 50 =18, 15, and 38 nM, respectively). SSR504734 exhibits activity in schizophrenia, anxiety and depression models [1]. | |||
T5828 | MS21570 | GPR | |
MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice. | |||
T26646 | AQW051 | AQ W051,VQW-765,AQW-051 | AChR |
AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attrac... | |||
T28294 | Panadiplon | FG10571,FG-10571,FD-10571,PNU 78875,FG 10571,FD10571,FD 10571 | GABA Receptor |
Panadiplon (FG 10571) is a selective gamma-aminobutyric acid receptor agonist and partial agonist of 5GABAA, a benzodiazepine receptor, used in the treatment of anxiety disorders.Panadiplon exhibits selectivity for 5GABA... | |||
T22453 | Venlafaxine | Wy 45030 | Serotonin Transporter |
Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T20884 | Hydroxyzine | Hydroxyzine free base | Histamine Receptor |
Hydroxyzine (Hydroxyzine free base) is an antagonist of histamine H1-receptor. | |||
TN2004 | Obtusin | MAO , Monoamine Oxidase | |
Obtusin is a natural product. | |||
T4939 | Indole-3-pyruvic acid | 3-(3-Indolyl)-2-oxopropanoic acid | Others |
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmenta... | |||
T4S1999 | Valepotriate | Valtrate | Apoptosis , HIV Protease |
Valepotriate (Valtrate) fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agen... | |||
T4814 | (R)-5-Oxopyrrolidine-2-carboxylic acid | D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid | Others , Endogenous Metabolite |
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and di... | |||
T2O2777 | L-Threonine | threonine | Others , Endogenous Metabolite |
L-Threonine (threonine) is an essential amino acid in humans,an important amino acid for the nervous system,L-Threonine also plays an important role in porphyrin and fat metabolism and prevents fat buildup in the liver. ... | |||
T68953 | Arecoline | Reactive Oxygen Species , AChR | |
Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can in... | |||
T2940 | 6-Hydroxyflavone | 6-HF | GABA Receptor |
6-Hydroxyflavone (6-HF) is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It is reported in leaves of Barleria prionitis Linn. (a common Acanthaceae from India). 6-Hydro... | |||
TCS2170 | 2,5-Dihydroxyacetophenone | Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP | ERK , NF-κB , Tyrosinase |
1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-02924 | RGS1 Protein, Human, Recombinant (His) | Human | E. coli |
RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type I diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization o... | |||
TMPY-03991 | DBI Protein, Human, Recombinant (His) | Human | E. coli |
The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine rece... | |||
TMPY-01618 | GLO1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyox... | |||
TMPY-02648 | PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediate... |