| T0983 |
Penicillamine
|
d-penicillamin,Dimethyl Cysteine,Artamine,D-(-)-Penicillamine |
Antibiotic
|
|
Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl a... |
| T22644 |
C2 Ceramide
|
Ceramide |
Others
|
|
A potent modulator of cell proliferation and differentiation. |
| T3S2019 |
Lathyrol
|
|
Others
|
|
1.Lathyrol diterpenes is a modulator of P-glycoprotein dependent multidrug resistance. |
| T10233 |
Acetylarenobufagin
|
|
HIF
|
|
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator. |
| TN6773 |
Acetoxyvalerensre
|
acetylvalerenolic acid |
GABA Receptor
|
|
Acetoxyvalerensre (acetylvalerenolic acid) (acetylvalerenolic acid) is a derivative of valerenic acid, which is a a GABAA receptor modulator. |
| TQ0274 |
27-Hydroxycholesterol
|
25(R)-27-hydroxy Cholesterol |
Estrogen/progestogen Receptor
,
Liver X Receptor
|
|
|
| TN6457 |
N-trans-caffeoyltyramine
|
Trans-N-Caffeoyltyramine,N-(E)-Caffeoyl-lambda-tyramine,N-cis-Caffeoyltyramine,Typheramide |
Immunology/Inflammation related
|
|
N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) is a modulator of inflammatory responses and can be used in studies about treatment for chronic inflammatory diseases. |
| T2845 |
Imperatorin
|
Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen |
TRP/TRPV Channel
,
AChR
,
AChE
,
NOD
|
|
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo. |
| T34295 |
Resiniferatoxin
|
RTX,[3H]resiniferatoxin |
IL Receptor
|
|
Resiniferatoxin ([3H]resiniferatoxin) inhibits the production of Th1 cytokines, contributing to the defense against T. spiralis infection, and can be used in studies about the modulator of the immune response. |
| T3318 |
Wogonoside
|
Glychionide B,Wogonin 7-O-glucuronide,Oroxindin |
GABA Receptor
,
Autophagy
|
|
Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor. |
| T4720 |
6-Hydroxypyridin-2(1H)-one hydrochloride
|
2,6-Dihydroxypyridine hydrochloride |
Others
,
Endogenous Metabolite
|
|
6-Hydroxypyridin-2(1H)-one hydrochloride (2,6-Dihydroxypyridine hydrochloride) is used as a reagent to synthesize uridine phosphorylase inhibitors that increase Uridine (Urd) (U829910) levels. Uridine is a promising bioc... |
| TN2359 |
Iristectorigenin B
|
Iristectrigenin B |
Liver X Receptor
|
|
Iristectorigenin B (Iristectrigenin B) is a potent hepatic X-receptor (LXR) modulator, a small molecule compound isolated from Belamcanda chinensis.Iristectrigenin B promotes the expression of ABCA264 and ABCG7 in macrop... |
| TN1879 |
Lucideric acid A
|
Lucidenic acid A |
MMP
,
p38 MAPK
,
JNK
|
|
Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK/MAPKs activation. |
| TN3174 |
6-Methoxyflavanone
|
NSC50184 |
GABA Receptor
|
|
6-Methoxyflavanone (6-MeOF) is A positive allosteric modulator of the GABA response of human recombinant GABA A receptor, with antianxiety and anti-inflammatory activity, and can be used to reduce cisplatin induced neuro... |
| T14046 |
Anandamide
|
(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide |
Cannabinoid Receptor
,
Endogenous Metabolite
|
|
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous sy... |
| TN1325 |
(2S)-6-Prenylnaringenin
|
6-Prenylnaringenin,6-PN |
GABA Receptor
|
|
(2S)-6-Prenylnaringenin (6-Prenylnaringenin) is an isomer of the potent phytoestrogen, 8-prenylnaringenin. (2S)-6-Prenylnaringenin is the most potent compound in the forebrain and acts as a positive allosteric modulator ... |
| TN1420 |
Bacopaside I
|
|
Others
|
|
Bacopaside I is a saponin isolated from Bacopa monniera. Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 ... |
| T2946 |
Tanshinone IIA sulfonate sodium
|
Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium |
CaMK
,
P450
,
Calcium Channel
|
|
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor... |
| TN1202 |
(-)-α-Pinene
|
(1S)-(-)-Alpha-Pinene |
Virus Protease
,
GABA Receptor
,
Endogenous Metabolite
,
Antibacterial
|
|
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directl... |
| T1549 |
Raloxifene hydrochloride
|
LY156758 hydrochloride,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl |
Estrogen Receptor/ERR
,
Others
,
MAO
,
Estrogen/progestogen Receptor
,
Autophagy
|
|
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and chol... |
| T4S0181 |
Hinokiflavone
|
|
MMP
,
BCL
,
E1/E2/E3 Enzyme
|
|
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO... |
| T15248 |
Estetrol
|
Donesta |
Estrogen Receptor/ERR
,
Endogenous Metabolite
|
|
Estetrol(Donesta) is an orally available, selective modulator of the estrogen receptor, a naturally occurring estrogen synthesized by the human fetal liver during pregnancy.Estetrol has effects on the endometrium or cent... |
| T3923 |
Calycosin
|
Cyclosin,3'-Hydroxyformononetin |
Apoptosis
,
Tyrosinase
|
|
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c... |
| T4S21320 |
ISOGINKGETIN
|
4',4'''-Dimethylamentoflavone |
MMP
,
Others
|
|
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... |
| T3753 |
Sinapinic Acid
|
Sinapic acid,Synapoic acid |
Apoptosis
,
RAAS
,
Reactive Oxygen Species
,
HDAC
|
|
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap... |
| T24744 |
Rubone
|
|
|
|
Rubone is the tumor suppressor miRNA-34a modulator that acts by inhibiting the growth of hepatocellular carcinoma. |
| TMA1004 |
Lucidenic acid F
|
|
p38 MAPK
,
JNK
|
|
Lucidenic acid F as a modulator of JNK and p38, it shows potent inhibitory effects on EBV-EA induction. |
| TN2116 |
Pteropodine
|
|
BCL
,
Calcium Channel
,
5-HT Receptor
|
|
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows strong apoptotic effect on acute leukaemic l... |
| T12787 |
Ryanodine
|
|
Others
|
|
Ryanodine, a diterpenoid poison derived from Ryania speciosa, acts as a modulator of the ryanodine receptor, which is permeable to cells. Depending on its concentration, ryanodine can either stimulate or inhibit Ca2+ rel... |
| T14831 |
Bryostatin 1
|
|
HIV Protease
,
PKC
|
|
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.0... |
| TN1099 |
Dihydroevocarpine
|
|
MAO
,
P-gp
,
Antifection
|
|
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it s... |
| TN1842 |
Kushenol I
|
|
GABA Receptor
,
Antifection
|
|
Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumeri... |
| TN4016 |
Ethyl 2,4,6-trihydroxybenzoate
|
|
Liver X Receptor
|
|
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular ch... |
| TMA0424 |
Martynoside
|
|
ROS
|
|
Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynoside has the potential of antagonizing sports anaemia, the me... |
| TN1790 |
Isopteropodine
|
Uncarine E |
5-HT Receptor
,
Antibacterial
,
AChR
|
|
Isopteropodine (Uncarine E) is an isoyohimbine-type octindole alkaloid isolated from Hamelia patens micropropagated and has antimicrobial activity and stimulates the immune system. Isopteropodine has antimicrobial activi... |
| TN4635 |
Neoechinulin A
|
|
NADPH-oxidase
,
Beta Amyloid
,
ASK
,
IκB/IKK
,
p38 MAPK
,
TNF
,
NOS
,
NF-κB
,
COX
,
Prostaglandin Receptor
|
|
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) ... |
