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Search Results for " mutations "

ターゲット

Raf Ras

152

阻害剤

天然化合物

386

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T5469	K-Ras-IN-1		Raf , Ras
	K-Ras-IN-1 is a K-Ras inhibitor.		Raf , Ras
T36287	Pirtobrutinib		BTK
	Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to t...		BTK
T9689	M4205		c-Kit
	M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.		c-Kit
T22318	Taletrectinib	DS-6051b,AB-106	Trk receptor , ROS , ROS Kinase
	Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.		Trk receptor , ROS , ROS Kinase
T2680	NVP-BVU972		c-Met/HGFR
	NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.		c-Met/HGFR
T6311	Bafetinib	NS-187,INNO-406	Bcr-Abl , Src , Autophagy
	Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.		Bcr-Abl , Src , Autophagy
T4473	Ibiglustat	Venglustat,SAR402671,GZ402671	Transferase
	Ibiglustat (GZ402671) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a key intermediate in the synthe...		Transferase
T5462	Almonertinib	HS-10296	EGFR
	Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.		EGFR
T0975	Chlorambucil	CB-1348,Chloroambucil,WR-139013	DNA Alkylator/Crosslinker , DNA Alkylation
	Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arr...		DNA Alkylator/Crosslinker , DNA Alkylation
T5675	Almonertinib hydrochloride	HS-10296 hydrochloride	EGFR
	Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.		EGFR
T3709	XMD8-87	ACK1-B19	Tyrosinase , PPAR
	XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.		Tyrosinase , PPAR
T3630	Relugolix	RVT-601,TAK-385	GNRH Receptor
	Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively bi...		GNRH Receptor
T31425	Dibenz[a,h]anthracene	CCRIS 208,NSC 22433,AI3-18996,DB(a,h)A	DNA
	Dibenz[a,h]anthracene (CCRIS 208) has induced DNA damage and gene mutations in bacteria and gene mutations and transformation in several types of mammalian cell cultures.		DNA
T67839	HG106		Others
	HG106, which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene., which is anti-inflammatory and may be used to treat the growth of diseases...		Others
T33296	Merodantoin		Apoptosis
	Merodantoin is an apoptosis inducer and triggers cell apoptosis associated with ROS-dependent autophagy. Merodantoin targets cancer cells expressing KRAS mutations involved in Akt-dependent ROS production.		Apoptosis
T9754	BLU-945	BLU945,BLU 945	EGFR
	BLU-945 is a potent, highly selective, reversible, and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effective against EGFR with L858R and/or exon 19 deletion mutations, T790M, and C797...		EGFR
T7175	Alflutinib mesylate	AST2818 mesylate	EGFR
	Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.		EGFR
T15551	IDH889		Dehydrogenase
	IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).		Dehydrogenase
T8006	Oncrasin-1		Apoptosis , Raf , Ras
	Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations		Apoptosis , Raf , Ras
T22254	Alflutinib	AST2818,ASK120067	EGFR , P450
	Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.		EGFR , P450
T9601	Tepotinib hydrochloride(1 : x)		c-Met/HGFR , P-gp , ABC
	Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.		c-Met/HGFR , P-gp , ABC
T2473	PLX-4720	PLX4720	Raf
	PLX-4720 is a potent and selective inhibitor of B-Raf (V600E) (IC50: 13 nM), equally potent to c-Raf-1(Y340D and Y341D mutations).		Raf
T1805	Ataluren	PTC124	CFTR , Autophagy
	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...		CFTR , Autophagy
T35366	4-Nitroquinoline 1-oxide	4-Nitroquinoline 1-oxide,4Nqo,NQO,4-NQO,4-Nitroquinoline-N-oxide,NQNO	Others
	4-Nitroquinoline 1-oxide (4-NQO) is a chemical carcinogen that induces mutations in bacteria, fungi, and animals through the formation of large amounts of purine adducts.		Others
T11224	Rineterkib	ERK-IN-1	ERK , Raf
			ERK , Raf
T22438	Tetramethylthiuram monosulfide	TMTM	Others
	Tetramethylthiuram monosulfide is widely used as a catalyst in rubber-processing techniques, it possesses a medium-degree toxicity and causes point mutations in strains TA 100 and TA 1535 (Salmonella typhimurium LT 2).		Others
T9865	Almonertinib mesylate		EGFR
	Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer st...		EGFR
T38846	Vevorisertib trihydrochloride	ARQ 751 trihydrochloride	Akt
	Vevorisertib trihydrochloride (ARQ 751 trihydrochloride) is a selective and potent inhibitor of pan-AKT and AKT1-E17K mutations, inhibiting AKT1, AKT2 and AKT3. Vevorisertib trihydrochloride is used in the study of hepat...		Akt
T9141	ERK-IN-3	ASN007 free base	ERK
	ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.		ERK
T9072	Tuxobertinib	BDTX-189	EGFR , HER , BTK , RIP kinase
	Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activ...		EGFR , HER , BTK , RIP kinase
T22324	Ensartinib hydrochloride	Ensartinib dihydrochloride,X-396 dihydrochloride	Others , Trk receptor , c-Met/HGFR , ALK
	Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both...		Others , Trk receptor , c-Met/HGFR , ALK
T2551	Etravirine	TMC125,R165335	HIV Protease , Reverse Transcriptase
	Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribe...		HIV Protease , Reverse Transcriptase
T14118	Acridine Orange hydrochloride		Others
	Acridine Orange hydrochloride is a fluorescent dye of cell-permeable. It binds to nucleic acids, resulting in an altered spectral emission.It is used as a supravital stain and in fluorescence cytochemistry. It may cause ...		Others
T13416	ZX-29		ALK
	ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.		ALK
T1765	Erastin		Ferroptosis , VDAC
	Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner. Erastin has anti-tumor activity and acts selectively on tumor cells with RAS-carcinogenic mutations. The product...		Ferroptosis , VDAC
T75129	Luxdegalutamide	ARV-766	Androgen Receptor , PROTACs
	Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades the wild-type androgen receptor AR, as well as AR LBD mutants incl...		Androgen Receptor , PROTACs
T72953	Zidesamtinib	NVL-520
	Zidesamtinib (NVL-520) is a potent, selective inhibitor of ROS1 fusions and resistance mutations, including the wild-type ROS1 and ROS1 G2032R, exhibiting IC50 values of 0.7 and 7.9 nM, respectively. It is orally active,...
T38995	Taletrectinib free base	AB-106freebase,Taletrectinib free base,IBI-344 free base,DS-6051b free base	ROS Kinase
	Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s...		ROS Kinase
T1448L	Dasatinib monohydrate	BMS-354825 Monohydrate	Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy
	Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit...
T3678	Entrectinib	RXDX-101,NMS-E628	Trk receptor , ROS , ALK , Autophagy , ROS Kinase
	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini...		Trk receptor , ROS , ALK , Autophagy , ROS Kinase
T4565	Tafamidis	Fx-1006A	Others
	Tafamidis (Fx-1006A) is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR di...		Others
T68599	Orphenadrine	Orphenadrine (free base)	Sodium Channel , NMDAR , AChR
	Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagoni...		Sodium Channel , NMDAR , AChR
T76883	Talacotuzumab	CSL 362,JNJ 56022473	Immunology/Inflammation related , Interleukin
	Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affinity for CD123, CD32b/c, CD16-158F and CD16-158V, with KD of...		Immunology/Inflammation related , Interleukin
T33946	PF-06439015 mesylate	PF 06439015,PF-06439015,PF06439015
	PF-06439015 overcomes clinical ALK (receptor tyrosine kinase anatropic lymphoma kinase) mutations resistant to krizotinib. Pf-06439015 is an effective selective inhibitor.
T31954	Glycidamide	LS1386,HSDB 7804,LS-1386,HSDB7804,HSDB-7804
	Glycidamide is a carcinogen and metabolite of acrylamide that induces DNA adduct formation and mutations.
T31013	Corrector C18	Corrector C 18,Corrector C-18
	Corrector C18 is a class I mutation corrector which rescues CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis.
T71051	OSU-53
	OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.
T39809	PRMT5-IN-14	PRMT5-IN-14
	PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
T39670	Oritinib mesylate	SH-1028 mesylate,Oritinib mesylate
	Oritinib mesylate (SH-1028) is a highly selective, orally active, pyrimidine-based irreversible inhibitor of epidermal growth factor receptor (EGFR) with a low half maximal inhibitory concentration (IC50) of 18 nM. It de...
T28409	Photoregulin1
	Photoregulin1 is a modulator of Nr2e3. Photoregulin1 slows the progression of photoreceptor degeneration in two common mouse models of autosomal dominant RP, the RhoP23H and the Pde6brd1 mutations.

Compounds

Synonym: DS-6051b,AB-106

Target: Trk receptor, ROS, ROS Kinase

Synonym: NS-187,INNO-406

Target: Bcr-Abl, Src, Autophagy

Ibiglustat

T4473

Synonym: Venglustat,SAR402671,GZ402671

Synonym: CB-1348,Chloroambucil,WR-139013

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Almonertinib hydrochloride

T5675

Synonym: HS-10296 hydrochloride

Target: Tyrosinase, PPAR

Relugolix

T3630

Synonym: RVT-601,TAK-385

Target: GNRH Receptor

Dibenz[a,h]anthracene

T31425

Synonym: CCRIS 208,NSC 22433,AI3-18996,DB(a,h)A

Synonym: BLU945,BLU 945

Target: EGFR

Alflutinib mesylate

T7175

Synonym: AST2818 mesylate

Target: Dehydrogenase

Oncrasin-1

T8006

Synonym:

Target: Apoptosis, Raf, Ras

Alflutinib

T22254

Synonym: AST2818,ASK120067

Target: EGFR, P450

Tepotinib hydrochloride(1 : x)

T9601

Synonym:

Target: c-Met/HGFR, P-gp, ABC

Target: CFTR, Autophagy

4-Nitroquinoline 1-oxide

T35366

Synonym: 4-Nitroquinoline 1-oxide,4Nqo,NQO,4-NQO,4-Nitroquinoline-N-oxide,NQNO

Tetramethylthiuram monosulfide

T22438

Synonym: TMTM

Target: Others

Almonertinib mesylate

T9865

Synonym:

Target: EGFR

Vevorisertib trihydrochloride

T38846

Synonym: ARQ 751 trihydrochloride

Target: Akt

ERK-IN-3

T9141

Synonym: ASN007 free base

Target: EGFR, HER, BTK, RIP kinase

Ensartinib hydrochloride

T22324

Synonym: Ensartinib dihydrochloride,X-396 dihydrochloride

Target: Others, Trk receptor, c-Met/HGFR, ALK

Etravirine

T2551

Synonym: TMC125,R165335

Target: HIV Protease, Reverse Transcriptase

Acridine Orange hydrochloride

Target: Ferroptosis, VDAC

Luxdegalutamide

T75129

Synonym: ARV-766

Target: Androgen Receptor, PROTACs

Taletrectinib free base

T38995

Synonym: AB-106freebase,Taletrectinib free base,IBI-344 free base,DS-6051b free base

Target: ROS Kinase

Dasatinib monohydrate

T1448L

Synonym: BMS-354825 Monohydrate

Target: Apoptosis, Bcr-Abl, Src, c-Kit, Ephrin Receptor, Autophagy

Entrectinib

T3678

Synonym: RXDX-101,NMS-E628

Target: Trk receptor, ROS, ALK, Autophagy, ROS Kinase

Synonym: Orphenadrine (free base)

Target: Sodium Channel, NMDAR, AChR

Talacotuzumab

T76883

Synonym: CSL 362,JNJ 56022473

Target: Immunology/Inflammation related, Interleukin

PF-06439015 mesylate

T33946

Synonym: PF 06439015,PF-06439015,PF06439015

Target:

Glycidamide

T31954

Synonym: LS1386,HSDB 7804,LS-1386,HSDB7804,HSDB-7804

Target:

Corrector C18

T31013

Synonym: Corrector C 18,Corrector C-18

Synonym: SH-1028 mesylate,Oritinib mesylate

カタログ番号	製品名	別名	ターゲット
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
T30969	Clitocine		Apoptosis , BCL
	Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carryin...		Apoptosis , BCL
T4918	DL-Glyceraldehyde	Glyceric aldehyde	Reductase
	DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, ...		Reductase
T36472	Tetrahydro-11-deoxy Cortisol
	Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cyto...
T36915	21-Deoxycortisol
	21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital a...
TN4108	Ganoderic acid Z		Antifection
	The binding affinities of ganoderic acid DM and ganoderic acid Z (ÎGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential s...		Antifection
TN1694	Gliotoxin		Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection
	Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.

天然物製品

Gefitinib

T1181

Synonym: ZD1839

Target: EGFR, Tyrosine Kinases, Autophagy

Clitocine

T30969

Synonym:

Target: Apoptosis, BCL

DL-Glyceraldehyde

T4918

Synonym: Glyceric aldehyde

Target: Reductase

Tetrahydro-11-deoxy Cortisol

Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02650	Alkaline phosphatase Protein, Human, Recombinant (His)	Human	HEK293
	ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activit...
TMPY-01059	BMPR2 Protein, Human, Recombinant (His)	Human	HEK293
	The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin...
TMPY-04153	RNF43 Protein, Human, Recombinant (His)	Human	HEK293
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr...
TMPY-05081	Notch 1 Protein, Human, Recombinant (hFc)	Human	HEK293
	NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair...
TMPY-04165	FGFR3 Protein, Human, Recombinant (His)	Human	HEK293
	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His)	Human	HEK293
	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-01935	C-Kit Protein, Human, Recombinant (His)	Human	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-01802	C-Kit Protein, Mouse, Recombinant (His)	Mouse	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-05655	C-Kit Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-04051	C-Kit Protein, Human, Recombinant (hFc)	Human	HEK293
	C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPJ-00249	TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated	Human	Human Cells
	Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-...
TMPJ-00735	PDGF-BB Protein, Human, Recombinant	Human	E. coli
	Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P...
TMPY-01168	ALK-1 Protein, Human, Recombinant (His)	Human	HEK293
	Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. ...
TMPY-00949	VEGFR3/FLT4 Protein, Human, Recombinant (His)	Human	HEK293
	Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-01936	VEGFR3/FLT4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belo...
TMPY-04113	KRAS Protein,Human,Recombinant(G12D & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-03855	DNase I Protein, Human, Recombinant (His)	Human	HEK293
	DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phos...
TMPY-04116	KRAS Protein,Human,Recombinant(G12C & Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-06056	KRAS Protein, Human, Recombinant (G12D, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-01888	KRAS Protein,Human, Recombinant (Q61H, His)	Human	E. coli
	K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-01009	TGFBI Protein, Human, Recombinant (His)	Human	HEK293
	TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several ...
TMPY-02312	CSF3R/G-CSFR Protein, Human, Recombinant (His)	Human	HEK293
	Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regula...
TMPY-03407	NQO1 Protein, Human, Recombinant (His)	Human	E. coli
	NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-...
TMPY-01413	Cripto Protein, Human, Recombinant (His)	Human	HEK293
	Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hy...
TMPY-02731	SPINK4 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-6 homolog and SPINK4, is a secreted protein that contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine...
TMPY-00751	TrkB Protein, Human, Recombinant (His)	Human	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-00828	Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)	Human	HEK293
	Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfat...
TMPY-05435	ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)	Human	HEK293
	The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In dis...
TMPY-03762	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadher...
TMPY-02231	TrkB Protein, Mouse, Recombinant (His)	Mouse	HEK293
	TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-01384	Endoglin/CD105 Protein, Human, Recombinant (His)	Human	HEK293
	Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD...
TMPY-03357	FGFR2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-01305	OSMR Protein, Human, Recombinant (His)	Human	HEK293
	Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the typ...
TMPY-00972	FGFR2 Protein, Human, Recombinant (His & hFc)	Human	HEK293
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-05242	CRLF2/TSLPR Protein, Human, Recombinant (His)	Human	HEK293
	Overexpression of cytokine receptor-like factor 2 (CRLF2) due to chromosomal rearrangement has been observed in acute lymphoblastic leukemia (ALL) and reported to contribute to oncogenesis and unfavorable outcome in ALL....
TMPY-00423	FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)	Human	HEK293
	FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibro...
TMPY-02335	OSMR Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the typ...
TMPY-02112	FGFR4 Protein, Human, Recombinant (His)	Human	HEK293
	Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid seque...
TMPY-01247	FLT3 Protein, Human, Recombinant (T227M, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-05157	TGFBR2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodoma...
TMPY-02934	IL-2RG Protein, Rat, Recombinant (His)	Rat	HEK293
	The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its...
TMPY-02476	CD96 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00857	IL-2RG Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its...
TMPY-02011	CD96 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-06022	FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
	The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product i...
TMPY-01815	FOLR1 Protein, Human, Recombinant (His)	Human	HEK293
	The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product i...
TMPY-01756	Transthyretin Protein, Human, Recombinant (His)	Human	HEK293
	Prealbumin/Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein that belongs to the Prealbumin / Transthyretin family. Prealbumin / Transthyretin is detected in serum and cereb...
TMPY-02926	IL-2RG Protein, Human, Recombinant (hFc)	Human	HEK293
	The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its...
TMPY-01803	FOLR1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product i...
TMPY-01084	TrkA Protein, Human, Recombinant (His)	Human	HEK293
	TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promot...
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Alkaline phosphatase Protein, Human, Recombinant (His)

TMPY-02650

Species: Human

Expression System: HEK293

BMPR2 Protein, Human, Recombinant (His)

TMPY-01059

Species: Human

Expression System: HEK293

RNF43 Protein, Human, Recombinant (His)

TMPY-04153

Species: Human

Expression System: HEK293

Notch 1 Protein, Human, Recombinant (hFc)

TMPY-05081

Species: Human

Expression System: HEK293

FGFR3 Protein, Human, Recombinant (His)

TMPY-04165

Species: Human

Expression System: HEK293

FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

TMPY-00341

Species: Human

Expression System: HEK293

c-Kit Protein, Human, Recombinant (His)

TMPY-01935

Species: Human

Expression System: HEK293

c-Kit Protein, Mouse, Recombinant (His)

TMPY-01802

Species: Mouse

Expression System: HEK293

c-Kit Protein, Rhesus, Recombinant (hFc)

TMPY-05655

Species: Rhesus

Expression System: HEK293

c-Kit Protein, Human, Recombinant (hFc)

TMPY-04051

Species: Human

Expression System: HEK293

TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated

TMPJ-00249

Species: Human

Expression System: Human Cells

PDGF-BB Protein, Human, Recombinant

TMPJ-00735

Species: Human

Expression System: E. coli

ALK-1 Protein, Human, Recombinant (His)

TMPY-01168

Species: Human

Expression System: HEK293

VEGFR3/FLT4 Protein, Human, Recombinant (His)

TMPY-00949

Species: Human

Expression System: HEK293

VEGFR3/FLT4 Protein, Mouse, Recombinant (His)

TMPY-01936

Species: Mouse

Expression System: HEK293

KRAS Protein,Human,Recombinant(G12D & Q61H, His)

TMPY-04113

Species: Human

Expression System: E. coli

DNase I Protein, Human, Recombinant (His)

TMPY-03855

Species: Human

Expression System: HEK293

KRAS Protein,Human,Recombinant(G12C & Q61H, His)

TMPY-04116

Species: Human

Expression System: E. coli

KRAS Protein, Human, Recombinant (G12D, His)

TMPY-06056

Species: Human

Expression System: E. coli

KRAS Protein,Human, Recombinant (Q61H, His)

TMPY-01888

Species: Human

Expression System: E. coli

TGFBI Protein, Human, Recombinant (His)

TMPY-01009

Species: Human

Expression System: HEK293

CSF3R/G-CSFR Protein, Human, Recombinant (His)

TMPY-02312

Species: Human

Expression System: HEK293

NQO1 Protein, Human, Recombinant (His)

TMPY-03407

Species: Human

Expression System: E. coli

Cripto Protein, Human, Recombinant (His)

TMPY-01413

Species: Human

Expression System: HEK293

SPINK4 Protein, Mouse, Recombinant (hFc)

TMPY-02731

Species: Mouse

Expression System: HEK293

TrkB Protein, Human, Recombinant (His)

TMPY-00751

Species: Human

Expression System: HEK293

Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)

TMPY-00828

Species: Human

Expression System: HEK293

ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)

TMPY-05435

Species: Human

Expression System: HEK293

E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc)

TMPY-03762

Species: Human

Expression System: HEK293

TrkB Protein, Mouse, Recombinant (His)

TMPY-02231

Species: Mouse

Expression System: HEK293

Endoglin/CD105 Protein, Human, Recombinant (His)

TMPY-01384

Species: Human

Expression System: HEK293

FGFR2 Protein, Mouse, Recombinant (hFc)

TMPY-03357

Species: Mouse

Expression System: HEK293

OSMR Protein, Human, Recombinant (His)

TMPY-01305

Species: Human

Expression System: HEK293

FGFR2 Protein, Human, Recombinant (His & hFc)

TMPY-00972

Species: Human

Expression System: HEK293

CRLF2/TSLPR Protein, Human, Recombinant (His)

TMPY-05242

Species: Human

Expression System: HEK293

FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)

TMPY-00423

Species: Human

Expression System: HEK293

OSMR Protein, Mouse, Recombinant (His)

TMPY-02335

Species: Mouse

Expression System: HEK293

FGFR4 Protein, Human, Recombinant (His)

TMPY-02112

Species: Human

Expression System: HEK293

FLT3 Protein, Human, Recombinant (T227M, His)

TMPY-01247

Species: Human

Expression System: HEK293

TGFBR2 Protein, Human, Recombinant (His)

TMPY-05157

Species: Human

Expression System: Baculovirus-Insect Cells

IL-2RG Protein, Rat, Recombinant (His)

TMPY-02934

Species: Rat

Expression System: HEK293

CD96 Protein, Mouse, Recombinant (His)

TMPY-02476

Species: Mouse

Expression System: HEK293

IL-2RG Protein, Mouse, Recombinant (His & hFc)

TMPY-00857

Species: Mouse

Expression System: HEK293

CD96 Protein, Human, Recombinant (His)

TMPY-02011

Species: Human

Expression System: HEK293

FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His)

TMPY-06022

Species: Cynomolgus,Rhesus

Expression System: HEK293

FOLR1 Protein, Human, Recombinant (His)

TMPY-01815

Species: Human

Expression System: HEK293

Transthyretin Protein, Human, Recombinant (His)

TMPY-01756

Species: Human

Expression System: HEK293

IL-2RG Protein, Human, Recombinant (hFc)

TMPY-02926

Species: Human

Expression System: HEK293

FOLR1 Protein, Mouse, Recombinant (His)

TMPY-01803

Species: Mouse

Expression System: HEK293

TrkA Protein, Human, Recombinant (His)

TMPY-01084

Species: Human

Expression System: HEK293

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カタログ番号	製品名
L1580	GPCR Compound Library Plus	338 compounds
	Well-chosen 338 GPCR targeting compounds with unique structures;
L1500	GPCR Compound Library	1940 compounds
	A unique collection of 1940 GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target identification and research;
L5300	Mitochondria-Targeted Compound Library	830 compounds
	A unique collection of 830 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
L9410	Covalent Inhibitor Library	1949 compounds
	A unique collection of 1949 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc.

ライブラリー

GPCR Compound Library Plus

L1580

Compounds: 338

GPCR Compound Library

L1500

Compounds: 1940

Mitochondria-Targeted Compound Library

L5300

Compounds: 830

Covalent Inhibitor Library

L9410

Compounds: 1949