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Search Results for " antineoplastic "

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カタログ番号	製品名	別名	ターゲット
T31424	DIBA	PD022551,NSC 654077,DIBA-1,PD-22551,DIBA (Antineoplastic)
	DIBA is an ER zinc finger inhibitor that inhibits ligand-dependent and non-dependent cell growth in TAM resistant breast cancer in vitro and in vivo.
T9262	MAT2A inhibitor 4		Others , Methionine Adenosyltransferase (MAT)
	MAT2A Inhibitor 4 acts as an inhibitor targeting the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A), offering potential utility in cancer research.		Others , Methionine Adenosyltransferase (MAT)
T7747	Datelliptium chloride hydrochloride		DNA/RNA Synthesis
	Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.		DNA/RNA Synthesis
T13386	Zandelisib		PI3K
	Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.		PI3K
T1564	Cisplatin	cis-Diaminodichloroplatinum,CDDP	DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T12401	Pemigatinib	INCB054828	FGFR
	Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).		FGFR
T9473	4SC-203		FLT
	4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEG...		FLT
T1307	Carmofur	HCFU	Nucleoside Antimetabolite/Analog , Virus Protease , SARS-CoV , DNA/RNA Synthesis
	Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
T8003	Methotrexate disodium		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
	Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
T12317	Orelabrutinib	ICP-022	BTK
	Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).		BTK
T15012	Crolibulin	EPC2407	Microtubule Associated
	Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.		Microtubule Associated
T1921	Alpelisib	BYL-719	PI3K
	Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity. Alpelisib inhibits PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM). Alpelisib has antitumor activity and is targeted to P...		PI3K
T23256	RS-25344 hydrochloride		PDE
	RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor		PDE
T4552	Fursultiamine	Diteftin,Judolor,Alinamin F	Others
	Fursultiamine (Alinamin F) is a disulfide derivative of thiamine, or an allithiamine. It has potential uses in the treatment of vitamin B1 deficiency.		Others
T1120	Dacarbazine	Imidazole Carboxamide,DTIC-Dome	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.
T7539	O6-Benzylguanine		Apoptosis , DNA Alkylation , DNA/RNA Synthesis
	O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.		Apoptosis , DNA Alkylation , DNA/RNA Synthesis
T5462	Almonertinib	HS-10296	EGFR
	Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.		EGFR
T20681	Estramustine	NSC-89201,NSC 89201,LEO 275,LEO275,NSC89201,LEO-275	Microtubule Associated
	Estramustine (LEO-275) is a nitrogen mustard linked to estradiol, usually as phosphate. Estramustine has been used to treat prostatic neoplasms; also has radiation protective properties. Estramustine is selectively taken...		Microtubule Associated
T5675	Almonertinib hydrochloride	HS-10296 hydrochloride	EGFR
	Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.		EGFR
T6410	Bexarotene	Ro 26-4455,Targretin,LGD1069	Retinoid Receptor , Autophagy
	Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).		Retinoid Receptor , Autophagy
T1199	Mitotane	Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD	Apoptosis , AChR
	Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors a...		Apoptosis , AChR
T1485	Methotrexate	NCI-C04671,WR19039,Amethopterin,CL14377	Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
	Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v...		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
T9445	Vepafestinib		c-RET
	Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].		c-RET
T1241	Altretamine	Hexamethylmelamine,NSC13875,RB-1515,ENT-50852,WR-95704	DNA Alkylator/Crosslinker , DNA Alkylation
	Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.		DNA Alkylator/Crosslinker , DNA Alkylation
T26972	Cedazuridine	(4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine	DNA Methyltransferase
	Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.		DNA Methyltransferase
T7660	IDO inhibitor 1		Indoleamine 2,3-Dioxygenase (IDO)
	IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.		Indoleamine 2,3-Dioxygenase (IDO)
T0244	Tilorone dihydrochloride		Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR
	Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.		Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR
T2492	Perifosine	NSC 639966,D21266,KRX-0401	Apoptosis , Akt , Autophagy
	Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.		Apoptosis , Akt , Autophagy
T1961	Vistusertib	AZD2014	Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
	Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.		Apoptosis , Akt , PI3K , S6 Kinase , mTOR , Autophagy
T2510	Galunisertib	LY2157299	TGF-beta/Smad
	Galunisertib (LY2157299) is an orally available inhibitor of TGFβRI kinase (IC50: 56 nM) with potential antineoplastic activity.		TGF-beta/Smad
T20048	Vidarabine phosphate		Antiviral
	Vidarabine phosphate is an adenosine monophosphate analog. It is the monophosphate ester of VIDARABINE. It also has antiviral and possibly antineoplastic properties.		Antiviral
T3389	Antitumor agent-21	TRX818	Others
	Antitumor agent-21 (TRX818) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities.		Others
T6153	Icotinib	BPI-2009,BPI-2009H,Conmana	EGFR
	Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.		EGFR
T1250	Thio-TEPA	Tiofosyl,Triethylenethiophosphoramide,Tiofosfamid	DNA Alkylator/Crosslinker , DNA Alkylation , Antibacterial , Antibiotic
	Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.
T17172	Trofosfamide		Antibacterial
	Trofosfamide is an orally bioavailable derivative of oxazaphosphorine.		Antibacterial
T6131	Pimasertib	AS703026,MSC1936369B,SAR 245509	MEK
	Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.		MEK
T6487	Encorafenib	LGX818	Raf
	Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.		Raf
T3091	Carmustine	bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris	DNA Alkylator/Crosslinker , DNA Alkylation
	Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.		DNA Alkylator/Crosslinker , DNA Alkylation
T6279L	Givinostat hydrochloride	ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl	HDAC
	Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineopla...		HDAC
T26889	Borofalan(10B)	L-4-Boronophenylalanine	Others
	Borofalan(10B) (L-4-Boronophenylalanine) echibits antineoplastic effects. Borofalan can be used in studies on recurrent or locally advanced head and neck cancer.		Others
T2666	Taladegib	LY2940680	Hedgehog/Smoothened , Smo
	Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.		Hedgehog/Smoothened , Smo
T2243	Serdemetan	JNJ-26854165	Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
	Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.		Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
T6121	Tepotinib	EMD-1214063,MSC2156119	Trk receptor , c-Met/HGFR , TAM Receptor
	Tepotinib (EMD-1214063) is an inhibitor of MET tyrosine kinase with potential antineoplastic activity.		Trk receptor , c-Met/HGFR , TAM Receptor
T8151	Mobocertinib	tak788	EGFR
	Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent		EGFR
T8945L	AST5902 mesylate(2412155-74-7 free base)		Drug Metabolite
	AST5902 mesylate is principal metabolite of Alflutinib in vivo. AST5902 mesylate exerts antineoplastic activity.		Drug Metabolite
T4320	Flumatinib	HHGV678	Bcr-Abl , PDGFR , c-Kit
	Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.		Bcr-Abl , PDGFR , c-Kit
T1524	Nilotinib	Tasigna,AMN107	Bcr-Abl , Autophagy
	Nilotinib (AMN107) is a second-generation Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.		Bcr-Abl , Autophagy
T8495	Alobresib	Vorolanib,GS-5829	Epigenetic Reader Domain
	Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.		Epigenetic Reader Domain
T3677	GSK2879552	GSK2879552 2HCl	Histone Demethylase
	GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential antineoplastic activity.		Histone Demethylase
T1759	OTSSP167	MELK inhibitor,OTS167	MELK
	OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.		MELK

Compounds

DIBA

T31424

Synonym: PD022551,NSC 654077,DIBA-1,PD-22551,DIBA (Antineoplastic)

Target: Others, Methionine Adenosyltransferase (MAT)

Datelliptium chloride hydrochloride

T7747

Synonym:

Target: DNA/RNA Synthesis

Synonym: cis-Diaminodichloroplatinum,CDDP

Target: DNA Alkylator/Crosslinker, Ferroptosis, DNA/RNA Synthesis, Autophagy

Target: Nucleoside Antimetabolite/Analog, Virus Protease, SARS-CoV, DNA/RNA Synthesis

Methotrexate disodium

T8003

Synonym:

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate

Target: Microtubule Associated

RS-25344 hydrochloride

Synonym: Diteftin,Judolor,Alinamin F

Target: Others

Dacarbazine

T1120

Synonym: Imidazole Carboxamide,DTIC-Dome

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

O6-Benzylguanine

T7539

Synonym:

Target: Apoptosis, DNA Alkylation, DNA/RNA Synthesis

Synonym: NSC-89201,NSC 89201,LEO 275,LEO275,NSC89201,LEO-275

Target: Microtubule Associated

Almonertinib hydrochloride

T5675

Synonym: HS-10296 hydrochloride

Target: EGFR

Bexarotene

T6410

Synonym: Ro 26-4455,Targretin,LGD1069

Target: Retinoid Receptor, Autophagy

Mitotane

T1199

Synonym: Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD

Target: Apoptosis, AChR

Methotrexate

T1485

Synonym: NCI-C04671,WR19039,Amethopterin,CL14377

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate

Synonym: Hexamethylmelamine,NSC13875,RB-1515,ENT-50852,WR-95704

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Cedazuridine

T26972

Synonym: (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine

Target: DNA Methyltransferase

IDO inhibitor 1

T7660

Synonym:

Target: Indoleamine 2,3-Dioxygenase (IDO)

Tilorone dihydrochloride

T0244

Synonym:

Target: Influenza Virus, HIF/HIF Prolyl-Hydroxylase, IFNAR

Perifosine

T2492

Synonym: NSC 639966,D21266,KRX-0401

Target: Apoptosis, Akt, Autophagy

Vistusertib

T1961

Synonym: AZD2014

Target: Apoptosis, Akt, PI3K, S6 Kinase, mTOR, Autophagy

Galunisertib

T2510

Synonym: LY2157299

Target: TGF-beta/Smad

Synonym: BPI-2009,BPI-2009H,Conmana

Target: EGFR

Thio-TEPA

T1250

Synonym: Tiofosyl,Triethylenethiophosphoramide,Tiofosfamid

Target: DNA Alkylator/Crosslinker, DNA Alkylation, Antibacterial, Antibiotic

Trofosfamide

T17172

Synonym:

Target: Antibacterial

Pimasertib

T6131

Synonym: AS703026,MSC1936369B,SAR 245509

Synonym: bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Givinostat hydrochloride

T6279L

Synonym: ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl

Target: HDAC

Borofalan(10B)

T26889

Synonym: L-4-Boronophenylalanine

Target: Hedgehog/Smoothened, Smo

Serdemetan

T2243

Synonym: JNJ-26854165

Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53

Tepotinib

T6121

Synonym: EMD-1214063,MSC2156119

Target: Trk receptor, c-Met/HGFR, TAM Receptor

AST5902 mesylate(2412155-74-7 free base)

T8945L

Synonym:

Target: Drug Metabolite

Flumatinib

T4320

Synonym: HHGV678

Target: Bcr-Abl, PDGFR, c-Kit

Nilotinib

T1524

Synonym: Tasigna,AMN107

Target: Bcr-Abl, Autophagy

Alobresib

T8495

Synonym: Vorolanib,GS-5829

Target: Epigenetic Reader Domain

GSK2879552

T3677

Synonym: GSK2879552 2HCl

Target: Histone Demethylase

OTSSP167

T1759

Synonym: MELK inhibitor,OTS167

Target: MELK

カタログ番号	製品名	別名	ターゲット
T5778	5,7-DIMETHOXYFLAVONE		Anti-infection , P450
	5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.		Anti-infection , P450
T6431	Levoleucovorin Calcium	Calcium Levofolinate,CL307782	Others , Antifolate
	Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.		Others , Antifolate
TN1375	α-Lapachone	alpha-Lapachone	Topoisomerase , Antifection
	α-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi.		Topoisomerase , Antifection
T1174	Topotecan hydrochloride	SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,Topotecan HCl	Apoptosis , Topoisomerase , Autophagy
	Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.		Apoptosis , Topoisomerase , Autophagy
T2807	Caffeic Acid		Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel
	Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities.		Lipoxygenase , Endogenous Metabolite , TRP/TRPV Channel
TN2101	Primin		Antifection
	Primin has antimycobacterial, and strong antineoplastic actions.		Antifection
T4614	Ellipticine hydrochloride	Ellipticine HCl,NSC 71795 (hydrochloride)	Topoisomerase
	Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.		Topoisomerase
T3801	(Rac)-Byakangelicin	Bjacangelicin,Bjakangelicin,Biacangelicin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-,Byakangelicin	Others
	(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) is an antineoplastic agent.		Others
T3S1707	Dendrophenol	Moscatilin	NF-κB
	Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.		NF-κB
TN1372	Alpha-Amyrin	alpha-Amyrenol,α-Amyrin,alpha-Amyrine,Viminalol	P450 , Serine Protease , ROS
	Alpha-Amyrin (alpha-Amyrine) is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepatomodulatory.		P450 , Serine Protease , ROS
T5784	Topotecan	NSC 609669,SKF 104864A	Topoisomerase , Autophagy
	Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.		Topoisomerase , Autophagy
T0051	Urethane	Ethyl carbamate,Ethylurethane,Carbamic acid ethyl ester	Chloride channel , GABA Receptor , Antibacterial , GluR , NMDAR , AChR , Parasite
	Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
T5A2455	Arenobufagin		Others
	Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells.		Others
T1059	Retinyl palmitate	Retinol palmitate,Vitamin A palmitate,Retinyl (Vitamin A) Palmitate	Others , Endogenous Metabolite
	Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.		Others , Endogenous Metabolite
T2898	Andrographolide	Andrographis	SARS-CoV , Influenza Virus , NF-κB , Autophagy
	Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic.		SARS-CoV , Influenza Virus , NF-κB , Autophagy
T1511	Daunorubicin hydrochloride	Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy
	Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
T2218	8-Azaguanine	Azaguanine-8,SK 1150,NSC-749,SF-337	Nucleoside Antimetabolite/Analog , Others , Endogenous Metabolite
	8-Azaguanine (SK 1150) is a purine analogue with potential antineoplastic activity.
T4803	(E/Z)-Demethoxycurcumin		Others
	Demethoxycurcumin is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent.		Others
T2993	Cordycepin	3'-Deoxyadenosine	MMP , TNF , Antibacterial , Antibiotic , Autophagy
	Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity.		MMP , TNF , Antibacterial , Antibiotic , Autophagy
T1737	Genistein	NPI 031L	Apoptosis , EGFR , Endogenous Metabolite , Autophagy
	Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.		Apoptosis , EGFR , Endogenous Metabolite , Autophagy
T2543	Cabazitaxel	XRP6258,RPR-116258A,TXD 258,taxoid XRP6258	Microtubule Associated , Autophagy
	Cabazitaxel (taxoid XRP6258) is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel.		Microtubule Associated , Autophagy
T8373	6-Diazo-5-oxo-L-nor-Leucine	DON,L-6-Diazo-5-oxonorleucine,Diazooxonorleucine	Influenza Virus , Glutaminase , Antibacterial , Antibiotic
	6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM). It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil.		Influenza Virus , Glutaminase , Antibacterial , Antibiotic
T2336	Vitamin K2	Menatetrenone	Endogenous Metabolite
	Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signaling of certain tyrosine kinases, thereby affecting several...		Endogenous Metabolite
T0983	Penicillamine	d-penicillamin,Dimethyl Cysteine,Artamine,D-(-)-Penicillamine	Antibiotic
	Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl a...		Antibiotic
T0650	Phenyl acetate	Acetylphenol,Phenol acetate,Acetic acid phenyl ester	Others , Endogenous Metabolite
	Phenyl acetate (Acetic acid phenyl ester) is an aromatic fatty acid metabolite of phenylalanine with potential antineoplastic activity. Naturally occurring in mammals, phenylacetate induces differentiation, growth inhibi...		Others , Endogenous Metabolite
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
T1705	5-Amino-3H-imidazole-4-Carboxamide	4-Amino-5-imidazolecarboxamide,AICA,5-Aminoimidazole-4-carboxamide	Endogenous Metabolite
	5-Amino-3H-imidazole-4-Carboxamide (AICA) is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparat...		Endogenous Metabolite
TN1087	Deoxypodophyllotoxin		Apoptosis , Microtubule Associated , Autophagy
	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.		Apoptosis , Microtubule Associated , Autophagy
T3314	Perillyl alcohol	Isocarveol,Perilla alcohol	Apoptosis , Endogenous Metabolite
	Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol (Isocarveol) inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-...		Apoptosis , Endogenous Metabolite
T6569	Mimosine	Leucenine,NSC 69188,Leucenol,L-Mimosine	Others
	L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.		Others
T1633	β-Carotene	Carotaben,Beta-Carotene,Provitamin A	Apoptosis , ROS , Endogenous Metabolite
	β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...		Apoptosis , ROS , Endogenous Metabolite
T1506	Vidarabine	Adenine Arabinoside,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A	Nucleoside Antimetabolite/Analog , Tyrosine Kinases , DNA/RNA Synthesis , Antibiotic , HSV
	Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and signific...
T1166	Ellipticine	NSC 71795,Elliptisine	Topoisomerase
	Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-6...		Topoisomerase
TN1215	(2S)-2'-Methoxykurarinone	2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt , Antifection
	(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone inhibits osteo...		Akt , Antifection
T1121	Podofilox	Podophyllotoxin,(+)-Shikonin	Microtubule Associated , Topoisomerase
	Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit...		Microtubule Associated , Topoisomerase
T1719	Bufalin		ATPase
	Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potenti...		ATPase
T5S0661	Koumine		Others
	1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of infla...		Others
T3524	Halofuginone hydrobromide	Tempostatin,RU-19110 (hydrobromide),Stenorol	Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T5S1467	Cucurbitacin E		CDK , Autophagy
	Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot...		CDK , Autophagy
T0186	Docetaxel trihydrate	RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate	Apoptosis , BCL , Microtubule Associated
			Apoptosis , BCL , Microtubule Associated
T1611	Isotretinoin	13-cis-Retinoic acid	Retinoid Receptor , Endogenous Metabolite , Autophagy
	Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall...		Retinoid Receptor , Endogenous Metabolite , Autophagy
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
T1591	Ancitabine hydrochloride	NSC 145668 HCl,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C	Others , DNA/RNA Synthesis , Autophagy
	Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytar...		Others , DNA/RNA Synthesis , Autophagy
T6429	Caffeic Acid Phenethyl Ester	Phenylethyl Caffeate,CAPE	Apoptosis , NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective...		Apoptosis , NF-κB
T4919	Ureidopropionic acid	Carbamoyl-b-alanine,3-Ureidopropionic acid	Endogenous Metabolite
	Ureidopropionic acid (3-Ureidopropionic acid) is an intermediate in the metabolism of uracil. More specifically it is a breakdown product of dihydrouracil and is produced by the enzyme dihydropyrimidase. It is further de...		Endogenous Metabolite
T4S0797	Berberine	Berberin,Umbellatine	Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy
	1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3....
T3S0027	Picropodophyllotoxin	AXL 1717,Picropodophyllin	IGF-1R
	Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...		IGF-1R
T26030	Rabdosin C	Isodonoiol,Rabdophyllin G
	Rabdosin C is an antineoplastic isolated from the leaves of Rabdosia japonic.
T3022	Anhydrovinblastine	3',4'-Anhydrovinblastine	Others
	3', 4'-Anhydrovinblastine (3',4'-Anhydrovinblastine) is an antineoplastic agent.		Others
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天然物製品

5,7-DIMETHOXYFLAVONE

T5778

Synonym:

Target: Anti-infection, P450

Levoleucovorin Calcium

T6431

Synonym: Calcium Levofolinate,CL307782

Target: Others, Antifolate

α-Lapachone

TN1375

Synonym: alpha-Lapachone

Target: Topoisomerase, Antifection

Topotecan hydrochloride

T1174

Synonym: SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,Topotecan HCl

Target: Apoptosis, Topoisomerase, Autophagy

Caffeic Acid

T2807

Synonym:

Target: Lipoxygenase, Endogenous Metabolite, TRP/TRPV Channel

Ellipticine hydrochloride

T4614

Synonym: Ellipticine HCl,NSC 71795 (hydrochloride)

Target: Topoisomerase

(Rac)-Byakangelicin

T3801

Synonym: Bjacangelicin,Bjakangelicin,Biacangelicin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-,Byakangelicin

Synonym: alpha-Amyrenol,α-Amyrin,alpha-Amyrine,Viminalol

Target: P450, Serine Protease, ROS

Topotecan

T5784

Synonym: NSC 609669,SKF 104864A

Target: Topoisomerase, Autophagy

Urethane

T0051

Synonym: Ethyl carbamate,Ethylurethane,Carbamic acid ethyl ester

Target: Chloride channel, GABA Receptor, Antibacterial, GluR, NMDAR, AChR, Parasite

Synonym: Retinol palmitate,Vitamin A palmitate,Retinyl (Vitamin A) Palmitate

Target: Others, Endogenous Metabolite

Andrographolide

T2898

Synonym: Andrographis

Target: SARS-CoV, Influenza Virus, NF-κB, Autophagy

Daunorubicin hydrochloride

T1511

Synonym: Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

8-Azaguanine

T2218

Synonym: Azaguanine-8,SK 1150,NSC-749,SF-337

Target: Nucleoside Antimetabolite/Analog, Others, Endogenous Metabolite

(E/Z)-Demethoxycurcumin

Synonym: 3'-Deoxyadenosine

Target: MMP, TNF, Antibacterial, Antibiotic, Autophagy

Genistein

T1737

Synonym: NPI 031L

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

Cabazitaxel

T2543

Synonym: XRP6258,RPR-116258A,TXD 258,taxoid XRP6258

Target: Microtubule Associated, Autophagy

6-Diazo-5-oxo-L-nor-Leucine

T8373

Synonym: DON,L-6-Diazo-5-oxonorleucine,Diazooxonorleucine

Target: Influenza Virus, Glutaminase, Antibacterial, Antibiotic

Vitamin K2

T2336

Synonym: Menatetrenone

Target: Endogenous Metabolite

Penicillamine

T0983

Synonym: d-penicillamin,Dimethyl Cysteine,Artamine,D-(-)-Penicillamine

Target: Antibiotic

Phenyl acetate

T0650

Synonym: Acetylphenol,Phenol acetate,Acetic acid phenyl ester

Target: Others, Endogenous Metabolite

Hypericin

T6S0923

Synonym: Hypericine,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

5-Amino-3H-imidazole-4-Carboxamide

T1705

Synonym: 4-Amino-5-imidazolecarboxamide,AICA,5-Aminoimidazole-4-carboxamide

Target: Endogenous Metabolite

Deoxypodophyllotoxin

TN1087

Synonym:

Target: Apoptosis, Microtubule Associated, Autophagy

Perillyl alcohol

T3314

Synonym: Isocarveol,Perilla alcohol

Target: Apoptosis, Endogenous Metabolite

Mimosine

T6569

Synonym: Leucenine,NSC 69188,Leucenol,L-Mimosine

Target: Others

β-Carotene

T1633

Synonym: Carotaben,Beta-Carotene,Provitamin A

Target: Apoptosis, ROS, Endogenous Metabolite

Vidarabine

T1506

Synonym: Adenine Arabinoside,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A

Target: Nucleoside Antimetabolite/Analog, Tyrosine Kinases, DNA/RNA Synthesis, Antibiotic, HSV

Ellipticine

T1166

Synonym: NSC 71795,Elliptisine

Target: Topoisomerase

(2S)-2'-Methoxykurarinone

TN1215

Synonym: 2'-Methoxykurarinone,2'-O-Methylkurarinone

Target: Akt, Antifection

Podofilox

T1121

Synonym: Podophyllotoxin,(+)-Shikonin

Target: Microtubule Associated, Topoisomerase

Halofuginone hydrobromide

T3524

Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Cucurbitacin E

T5S1467

Synonym:

Target: CDK, Autophagy

Docetaxel trihydrate

T0186

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate

Target: Apoptosis, BCL, Microtubule Associated

Isotretinoin

T1611

Synonym: 13-cis-Retinoic acid

Target: Retinoid Receptor, Endogenous Metabolite, Autophagy

2-Methoxyestradiol

T2220

Synonym: NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

Calycosin

T3923

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

Ancitabine hydrochloride

T1591

Synonym: NSC 145668 HCl,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C

Target: Others, DNA/RNA Synthesis, Autophagy

Caffeic Acid Phenethyl Ester

T6429

Synonym: Phenylethyl Caffeate,CAPE

Target: Apoptosis, NF-κB

Ureidopropionic acid

T4919

Synonym: Carbamoyl-b-alanine,3-Ureidopropionic acid

Target: Endogenous Metabolite

Berberine

T4S0797

Synonym: Berberin,Umbellatine

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Picropodophyllotoxin

T3S0027

Synonym: AXL 1717,Picropodophyllin

Target: IGF-1R

Rabdosin C

T26030

Synonym: Isodonoiol,Rabdophyllin G

Target:

Anhydrovinblastine

T3022

Synonym: 3',4'-Anhydrovinblastine

Target: Others

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03431	HDAC4 Protein, Human, Recombinant (aa 612-1084)	Human	Baculovirus-Insect Cells
	HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups ...

HDAC4 Protein, Human, Recombinant (aa 612-1084)

TMPY-03431

Species: Human

Expression System: Baculovirus-Insect Cells

カタログ番号	製品名
L6100	Polyphenolic Natural Product Library		635 compounds
	A unique collection of 635 natural polyphenolic compounds for high throughput screening (HTS) and high content screening (HCS);

ライブラリー

Polyphenolic Natural Product Library

L6100

Compounds: 635