Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is on the World Health Organization's List of Essential Medicines.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 7,500 | |||
50 mg | 在庫あり | ¥ 11,000 | |||
100 mg | 在庫あり | ¥ 18,000 | |||
200 mg | 在庫あり | ¥ 26,000 | |||
500 mg | 在庫あり | ¥ 43,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,000 |
説明 | Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is on the World Health Organization's List of Essential Medicines. |
In vitro | ART could alter the biomechanical properties of the glioma cells to inhibit cell proliferation, migration and invasion [2]. The ART significantly suppresses the cell proliferation, induces the apoptosis and promoted cell cycle arrest at G0/G1 phase in SKM-1 cells. The mechanisms of ART anti-MDS is associated with the increase of intracellular calciumion concentration and ROS levels. In addition, the pro-apoptotic activity of ART may be involved in the regulation of BCL-2 /BAX ratio and the expressions of P-bad and survivin[3]. ART treatment demethylates CDH1, which, in turn recovers the E-cadherin activation in SKM-1 cells[1]. |
In vivo | Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice[5]. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen[6]. |
細胞研究 | Growth inhibition assay: The SKM-1 cells (1×105/mL) are firstly seeded in 96-well plates. Artesunate is diluted in 0.1% dimethyl sulfoxide (DMSO) producing 0, 12.5, 25, 50µg/mL concentrations and added to the SKM-1 cells with 100 µl per well. A negative control is treated with 0.1% DMSO. At 0, 24, 48, and 72 hours, same amount of MTT solution is added into each well and cultured for extra 4 hours. MTT treated cells are fixed with 150 µL DMSO for 30 min at room temperature and then determined with Evolution 201 and 220 UV-Vis spectrophotometer system at 540 nm. (Only for Reference) |
植物由来 |
別名 | WR-256283 |
分子量 | 384.42 |
分子式 | C19H28O8 |
CAS No. | 88495-63-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 9 mg/mL(23.4 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (143.07 mM)
You can also refer to dose conversion for different animals. 詳細
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Artesunate 88495-63-0 Apoptosis JAK/STAT signaling Microbiology/Virology Stem Cells STAT Parasite Ferroptosis Virus Protease inhibit WR256283 WR 256283 WR-256283 Inhibitor inhibitor