Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.
説明 | Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. |
ターゲット&IC50 | M1 receptor:9.5 nM(ki) |
別名 | HF 1854, LX 100-129 |
分子量 | 326.82 |
分子式 | C18H19ClN4 |
CAS No. | 5786-21-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.7 mg/mL (100 mM)
2eq.HCl: 16.3 mg/mL (50 mM)), Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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Clozapine 5786-21-0 GPCR/G Protein Neuroscience AChR Adrenergic Receptor Dopamine Receptor antipsychotic Inhibitor psychosis mAChR 5-hydroxytryptamine Receptor Beta Receptor 5-HT Receptor HF 1854 HF-1854 schizophrenia HF1854 inhibit LX 100-129 HeLa Serotonin Receptor Muscarinic acetylcholine receptor inhibitor