Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
説明 | Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K. |
ターゲット&IC50 | DNA-PK:0.28 μM |
In vitro | Compound 401 shows activity against mTOR (IC50 = 5.3 μM) but not p110α/p85α PI3K (IC50 > 100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr389 and Akt Ser473, respectively). |
別名 | 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one |
分子量 | 281.31 |
分子式 | C16H15N3O2 |
CAS No. | 168425-64-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.45 mg/mL (19.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Compound 401 168425-64-7 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling DNA-PK 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one Compound401 DNA-dependent protein kinase Compound-401 inhibit Inhibitor inhibitor