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Search Results for " cascade "

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カタログ番号 製品名 別名 ターゲット
T0432 Diclofenac diethylamine Apoptosis , COX
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).
T0196 Diclofenac Diclofenacum,Voltaren Apoptosis , COX
Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of a...
T6470 Diclofenac Potassium CGP-45840B,Cataflam,Voltfast Apoptosis , Others , COX
Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
T1555 Diclofenac sodium GP 45840 Apoptosis , COX
Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
T24784 SF5 SF-5,SF 5 Apoptosis
SF5 is an inhibitor of the apoptosis pathway. Which is through the JNK-p53-caspase apoptotic cascade.
T7582 Tafamidis meglumine Fx-1006A Others
Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade
T8570 L524-0366 [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone Others
L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.
T8428 Subasumstat TAK-981 E1/E2/E3 Enzyme
Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.
T2648 Pimecrolimus SDZ-ASM 981,ASM 981 Others
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...
T124384 Jasmonic acid (-)-Jasmonic acid
Jasmonic acid (JA) is a phytohormone and plant growth regulator involved in plant defense and growth and development.Jasmonic acid plays an important role in signaling, inducing the MAP kinase cascade pathway and calcium...
T26629 Angstrom6 A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide PAI-1
Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.Angstrom6 has antitumor a...
T11994 Melagatran Thrombin
Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinolytic enzymes. It does not rely on endogenous co-factors to e...
T9014 SKI-178 Apoptosis , S1P Receptor
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...
T40063 CBR-470-1 Nrf2
CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protect...
T3560 Desmethylanethol trithione ADT-OH VEGFR , Akt
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly...
T2170 SKF-96365 hydrochloride SKF96365 Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy
SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha...
T69500 YO-2
YO-2 is a selective plasmin inhibitor. YO-2 induces thymocyte apoptosis via activation of caspase cascade.
T76953 Xeligekimab
Xeligekimab (GR 1501) is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A) to inhibit the pro-inflammatory cascade [1].
TP1950 PEN(mouse) PEN (mouse)
Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide. Activates phospholipase C (PLC)-mediated signaling cascade in mouse hypothalamus.
T25377 EP6 EP-6,EP 6
EP6 is an inhibitor of 5-lipoxygenase (5-LO), which is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and all...
T64001 MAP855
MAP855 is a potent, selective, orally active, ATP-competitive MEK1/2 kinase inhibitor with an IC50 value of 3 nM for MEK1 ERK2 cascade and a pERKEC50 value of 5 nM. MAP855 exhibits equal inhibition of wild-type and mutan...
T36331 Z-AEVD-FMK Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 &#181M, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its activ...
T25050 Alloferon 3
Alloferon 3 is a natural peptide that mediates signaling by the NF-kappa B pathway to enhance the recognition of viral and tumor antigens. It is known to induce the production of endogenic interferons that promote a casc...
T70234 Cacospongionolide B
Cacospongionolide B is isolated from the sponge Fasciospongia cavernosa. The marine sponge natural product cacospongionolide B (1) is one of a class of compounds bearing a g-hydroxybutenolide which are known to inhibit m...
T68267 RO5068760
RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen...
T37556 CAY10502
Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme tha...
T22676 Prothrombin (474-477) [Mus musculus] Others
Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothro...
T78924 TPE-1p
TPE-1p, a cascade-activated AIEgen-peptide probe, self-assembles in aqueous solution to produce bright fluorescence upon interaction with alkaline phosphatase (ALP) and ChT-L. It facilitates noninvasive evaluation of ChT...
T76273 Pep19-2.5
Pep19-2.5, a synthetic antitoxin peptide, inhibits the intracellular signaling cascade triggered by endotoxins by blocking the activity of lipopeptides (LP) and lipopolysaccharides (LPS) mediated through both transmembra...
T74068 WH-15
WH-15 is a fluorogenic phospholipase C (PLC) reporter, exhibiting Michaelis-Menten constant (Km) values of 49, 30, and 86.1 µM for PLC-γ1, PLC-δ1, and PLC-β2, respectively. It undergoes enzymatic cleavage in a cascade re...
T73701 Urokinase (peptidolytic)
Urokinase peptidolytic (Urokinase-type plasminogen activator) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in t...
T76059 SAH-SOS1A TFA
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA di...
T37030 PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dio...
T78007 Vasonatrin Peptide (VNP) TFA
Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, ...
T37026 Mesalamine impurity P
Mesalamine impurity P is an impurity of Mesalamine . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1]. [1]. Kyle Dammann, et al.PAK1 modulat...
T36937 PtdIns-(1,2-dioctanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl...
T74844 Antiproliferative agent-23
Antiproliferative agent-23, a microtubule-destabilizing agent (MDA), disrupts the tubulin-microtubule system, leading to apoptosis through a mitochondrion-dependent pathway. This involves downregulation of Bcl-2 protein,...
T35491 3,5-dimethyl PIT-1
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is impor...
T64692 AMY-101 acetate
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exe...
T37367 Amyloid-β (1-42) Peptide (trifluoroacetate salt)
Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of ne...

Compounds

Diclofenac diethylamine
T0432
Synonym:
Target: Apoptosis, COX
Diclofenac
T0196
Synonym: Diclofenacum,Voltaren
Target: Apoptosis, COX
Diclofenac Potassium
T6470
Synonym: CGP-45840B,Cataflam,Voltfast
Target: Apoptosis, Others, COX
Diclofenac sodium
T1555
Synonym: GP 45840
Target: Apoptosis, COX
SF5
T24784
Synonym: SF-5,SF 5
Target: Apoptosis
tafamidis meglumine
T7582
Synonym: Fx-1006A
Target: Others
L524-0366
T8570
Synonym: [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
Target: Others
Subasumstat
T8428
Synonym: TAK-981
Target: E1/E2/E3 Enzyme
Pimecrolimus
T2648
Synonym: SDZ-ASM 981,ASM 981
Target: Others
Jasmonic acid
T124384
Synonym: (-)-Jasmonic acid
Target:
Angstrom6
T26629
Synonym: A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide
Target: PAI-1
Melagatran
T11994
Synonym:
Target: Thrombin
SKI-178
T9014
Synonym:
Target: Apoptosis, S1P Receptor
CBR-470-1
T40063
Synonym:
Target: Nrf2
Desmethylanethol trithione
T3560
Synonym: ADT-OH
Target: VEGFR, Akt
SKF-96365 hydrochloride
T2170
Synonym: SKF96365
Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy
YO-2
T69500
Synonym:
Target:
Xeligekimab
T76953
Synonym:
Target:
PEN(mouse)
TP1950
Synonym: PEN (mouse)
Target:
EP6
T25377
Synonym: EP-6,EP 6
Target:
MAP855
T64001
Synonym:
Target:
Z-AEVD-FMK
T36331
Synonym: Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
Target:
Alloferon 3
T25050
Synonym:
Target:
Cacospongionolide B
T70234
Synonym:
Target:
RO5068760
T68267
Synonym:
Target:
CAY10502
T37556
Synonym:
Target:
Prothrombin (474-477) [Mus musculus]
T22676
Synonym:
Target: Others
TPE-1p
T78924
Synonym:
Target:
Pep19-2.5
T76273
Synonym:
Target:
WH-15
T74068
Synonym:
Target:
Urokinase (peptidolytic)
T73701
Synonym:
Target:
SAH-SOS1A TFA
T76059
Synonym:
Target:
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
T37030
Synonym: PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
Target:
Vasonatrin Peptide (VNP) TFA
T78007
Synonym:
Target:
Mesalamine impurity P
T37026
Synonym:
Target:
PtdIns-(1,2-dioctanoyl) (sodium salt)
T36937
Synonym:
Target:
Antiproliferative agent-23
T74844
Synonym:
Target:
3,5-dimethyl PIT-1
T35491
Synonym:
Target:
AMY-101 acetate
T64692
Synonym:
Target:
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
T37367
Synonym:
Target:
カタログ番号 製品名 別名 ターゲット
T7982 3,6-Dihydroxyflavone Others
3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.
T6S1844 Tenacissoside H Tenacissimoside C Others
Tenacissoside H (Tenacissimoside C) has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade.
T6S1740 Nardosinone Others
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...
T27305 Fascaplysin chloride NSC622398,NSC 622398,Fascaplysin,NSC-622398
Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human ...
T1033L Monensin Elancoban,Rumensin
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with d...
TN4410 Lappaol C P-gp , JNK
Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidat...
TN1072 Lappaol A P-gp , JNK
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidat...
T73717 CGAMP diammonium
cGAMP (Cyclic GMP-AMPP) diammonium serves as an intrinsic second messenger in metazoans, initiating the production of interferons upon cytosolic DNA detection. It activates the stimulator of interferon genes (STING), sub...
TMA0984 Cerevisterol DNA/RNA Synthesis
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
T75600 Coronatine
Coronatine is a plant growth regulator synthesized by Pseudomonas syringae, mimicking bioactive jasmonic acid conjugates or octadecanoid signal molecules in higher plants, which induces pathogenic symptoms. It enhances t...
TN4411 Lappaol F CDK , P-gp , JNK
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be c...
T36954 Nemorosone
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma ce...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-01101 Coagulation factor X/F10 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the...
TMPY-01964 CD16a Protein, Human, Recombinant (F176V, His) Human HEK293 Cells
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also ...
TMPY-01806 CD9 Protein, Human, Recombinant (His) Human HEK293 Cells
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPJ-00375 HGF Protein, Human, Recombinant (His) Human HEK293 Cells
HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti...
TMPY-02185 Coagulation factor XIII B/F13B Protein, Human, Recombinant (His) Human HEK293 Cells
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ...
TMPH-02250 TPP2 Protein, Human, Recombinant (His & Myc) Human Baculovirus Insect Cells
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-01909 CPVL Protein, Human, Recombinant (His & SUMO) Human E. coli
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. CPVL Protein, Human, Recombinant (His & SU...
TMPK-00020 CD59 Protein, Human, Recombinant (hFc) Human HEK293 Cells
CD59 regulates complement activation cascade at the final step, inhibiting formation of membrane attack complex (MAC). This protein, being anchored to the cell membrane via glycosyl phosphatidyl inositol (GPI), is expres...
TMPK-01263 B7-H7 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances ...
TMPH-01295 Endothelin-1/EDN1 Protein, Human, Recombinant (GST) Human E. coli
Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial...
TMPJ-01383 Serpin A10 Protein, Human, Recombinant (His) Human HEK293 Cells
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits f...
TMPH-01385 GLP1R Protein, Human, Recombinant (His) Human HEK293 Cells
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-03757 TPP2 Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-03287 EPOR Protein, Rat, Recombinant (His & SUMO) Rat E. coli
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also ...
TMPH-00938 ANXA5 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. ANXA5 Protein, Human, Recombinant (His) is expressed...
TMPH-01692 MAPK3 Protein, Human, Recombinant (His) Human E. coli
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate...
TMPK-01370 GRP-10 proform Protein, Canine, Recombinant (hFc) Canine HEK293 Cells
Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have previously been suggested to play a role in the complex cascade of chemical activity associated...
TMPY-02252 LAMTOR2 Protein, Human, Recombinant (His) Human E. coli
Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-...
TMPJ-00770 Granzyme B/GZMB Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an...
TMPH-02881 Renin-2 Protein, Mouse, Recombinant (His) Mouse E. coli
Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood...
TMPH-03286 Endothelin-1/EDN1 Protein, Rat, Recombinant (His & KSI) Rat E. coli
Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial...
TMPK-01271 Coagulation factor XI Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to FXIa by factor XIIa (FXIIa), a co...
TMPH-01447 Human herpesvirus 2 (HHV-2) (strain HG52) Envelope glycoprotein C (His) HHV-2 E. coli
Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Plays also a role in host immune evasion by inhibiting the host complement cascade activation. Human her...
TMPK-00151 Complement Factor D/CFD Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPJ-01176 SEMA4C Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Semaphorin-4C is a protein which belongs to the semaphorin family, contains 1 Ig-like C2-type domain, 1 PSI domain, 1 Sema domain. As cell surface receptor for PLXNB2, it plays an important role in cell-cell signaling. P...
TMPH-03762 TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc) Mouse E. coli
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-02953 TPP2 Protein, Mouse, Recombinant (His & Myc) Mouse Baculovirus Insect Cells
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPK-00276 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting d...
TMPH-03301 GLP1R Protein, Rat, Recombinant (E. coli, His) Rat E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-02676 GLP1R Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-01384 GLP1R Protein, Human, Recombinant (E. coli, His) Human E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPJ-00396 SEMA4D Protein, Human, Recombinant (aa 22-734, His) Human HEK293 Cells
Semaphorin-4D is also known as A8,BB18, GR3, CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain, 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB...
TMPH-02270 Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO) Human E. coli
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melan...
TMPH-02269 Tyrosinase/TYR Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melan...
TMPH-01250 MAP2K3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that...
TMPH-02898 SPINK2 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defe...
TMPK-00277 TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc) Human HEK293 Cells
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter mol...
TMPJ-00163 R-Spondin 3/RSPO3 Protein, Human, Recombinant (hFc & His) Human HEK293 Cells
R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 rep...
TMPK-00671 Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His) Rhesus HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPK-00755 Complement Factor D/CFD Protein, Human, Recombinant (hFc) Human HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPH-00779 IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc) Guinea pig E. coli
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 b...
TMPJ-00844 ANXA8 Protein, Human, Recombinant Human E. coli
Annexin A8 (ANXA8) belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Annexin A8 contains 4 annexin repeats separated by linking sequences of variable lengths. A pair of annexin repeats ...
TMPJ-01378 Mp1 Protein, Human, Recombinant (His) Human E. coli
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding pro...
TMPK-00115 CD79B Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
CD79B (also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal tran...
TMPH-02606 CR1L Protein, Mouse, Recombinant (His) Mouse E. coli
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor,...
TMPJ-01125 PEA15 Protein, Human, Recombinant Human E. coli
Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis...
TMPH-02697 GNA12 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). G...
TMPJ-00080 IL-11 Protein, Human, Recombinant (P. pastoris) Human P. pastoris (Yeast)
Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that dir...
TMPH-02226 TEAD3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPJ-00215 Fas/CD95 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected...
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Coagulation factor X/F10 Protein, Human, Recombinant (His)
TMPY-01101
Species: Human
Expression System: Baculovirus Insect Cells
CD16a Protein, Human, Recombinant (F176V, His)
TMPY-01964
Species: Human
Expression System: HEK293 Cells
CD9 Protein, Human, Recombinant (His)
TMPY-01806
Species: Human
Expression System: HEK293 Cells
HGF Protein, Human, Recombinant (His)
TMPJ-00375
Species: Human
Expression System: HEK293 Cells
Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)
TMPY-02185
Species: Human
Expression System: HEK293 Cells
TPP2 Protein, Human, Recombinant (His & Myc)
TMPH-02250
Species: Human
Expression System: Baculovirus Insect Cells
CPVL Protein, Human, Recombinant (His & SUMO)
TMPH-01909
Species: Human
Expression System: E. coli
CD59 Protein, Human, Recombinant (hFc)
TMPK-00020
Species: Human
Expression System: HEK293 Cells
B7-H7 Protein, Cynomolgus, Recombinant (His)
TMPK-01263
Species: Cynomolgus
Expression System: HEK293 Cells
Endothelin-1/EDN1 Protein, Human, Recombinant (GST)
TMPH-01295
Species: Human
Expression System: E. coli
Serpin A10 Protein, Human, Recombinant (His)
TMPJ-01383
Species: Human
Expression System: HEK293 Cells
GLP1R Protein, Human, Recombinant (His)
TMPH-01385
Species: Human
Expression System: HEK293 Cells
TPP2 Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-03757
Species: Human
Expression System: E. coli
EPOR Protein, Rat, Recombinant (His & SUMO)
TMPH-03287
Species: Rat
Expression System: E. coli
ANXA5 Protein, Human, Recombinant (His)
TMPH-00938
Species: Human
Expression System: P. pastoris (Yeast)
MAPK3 Protein, Human, Recombinant (His)
TMPH-01692
Species: Human
Expression System: E. coli
GRP-10 proform Protein, Canine, Recombinant (hFc)
TMPK-01370
Species: Canine
Expression System: HEK293 Cells
LAMTOR2 Protein, Human, Recombinant (His)
TMPY-02252
Species: Human
Expression System: E. coli
Granzyme B/GZMB Protein, Mouse, Recombinant (His)
TMPJ-00770
Species: Mouse
Expression System: HEK293 Cells
Renin-2 Protein, Mouse, Recombinant (His)
TMPH-02881
Species: Mouse
Expression System: E. coli
Endothelin-1/EDN1 Protein, Rat, Recombinant (His & KSI)
TMPH-03286
Species: Rat
Expression System: E. coli
Coagulation factor XI Protein, Cynomolgus, Recombinant (His)
TMPK-01271
Species: Cynomolgus
Expression System: HEK293 Cells
Human herpesvirus 2 (HHV-2) (strain HG52) Envelope glycoprotein C (His)
TMPH-01447
Species: HHV-2
Expression System: E. coli
Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)
TMPK-00151
Species: Mouse
Expression System: HEK293 Cells
SEMA4C Protein, Mouse, Recombinant (hFc)
TMPJ-01176
Species: Mouse
Expression System: HEK293 Cells
TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)
TMPH-03762
Species: Mouse
Expression System: E. coli
TPP2 Protein, Mouse, Recombinant (His & Myc)
TMPH-02953
Species: Mouse
Expression System: Baculovirus Insect Cells
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)
TMPK-00276
Species: Human
Expression System: HEK293 Cells
GLP1R Protein, Rat, Recombinant (E. coli, His)
TMPH-03301
Species: Rat
Expression System: E. coli
GLP1R Protein, Mouse, Recombinant (His & SUMO)
TMPH-02676
Species: Mouse
Expression System: E. coli
GLP1R Protein, Human, Recombinant (E. coli, His)
TMPH-01384
Species: Human
Expression System: E. coli
SEMA4D Protein, Human, Recombinant (aa 22-734, His)
TMPJ-00396
Species: Human
Expression System: HEK293 Cells
Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO)
TMPH-02270
Species: Human
Expression System: E. coli
Tyrosinase/TYR Protein, Human, Recombinant (His)
TMPH-02269
Species: Human
Expression System: P. pastoris (Yeast)
MAP2K3 Protein, Human, Recombinant (His & SUMO)
TMPH-01250
Species: Human
Expression System: E. coli
SPINK2 Protein, Mouse, Recombinant (His & Myc)
TMPH-02898
Species: Mouse
Expression System: E. coli
TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)
TMPK-00277
Species: Human
Expression System: HEK293 Cells
R-Spondin 3/RSPO3 Protein, Human, Recombinant (hFc & His)
TMPJ-00163
Species: Human
Expression System: HEK293 Cells
Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)
TMPK-00671
Species: Rhesus
Expression System: HEK293 Cells
Complement Factor D/CFD Protein, Human, Recombinant (hFc)
TMPK-00755
Species: Human
Expression System: HEK293 Cells
IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)
TMPH-00779
Species: Guinea pig
Expression System: E. coli
ANXA8 Protein, Human, Recombinant
TMPJ-00844
Species: Human
Expression System: E. coli
Mp1 Protein, Human, Recombinant (His)
TMPJ-01378
Species: Human
Expression System: E. coli
CD79B Protein, Human, Recombinant (His & Avi)
TMPK-00115
Species: Human
Expression System: HEK293 Cells
CR1L Protein, Mouse, Recombinant (His)
TMPH-02606
Species: Mouse
Expression System: E. coli
PEA15 Protein, Human, Recombinant
TMPJ-01125
Species: Human
Expression System: E. coli
GNA12 Protein, Mouse, Recombinant (His & Myc)
TMPH-02697
Species: Mouse
Expression System: E. coli
IL-11 Protein, Human, Recombinant (P. pastoris)
TMPJ-00080
Species: Human
Expression System: P. pastoris (Yeast)
TEAD3 Protein, Human, Recombinant (His & SUMO)
TMPH-02226
Species: Human
Expression System: E. coli
Fas/CD95 Protein, Mouse, Recombinant (hFc)
TMPJ-00215
Species: Mouse
Expression System: HEK293 Cells
カタログ番号 製品名
L3700 JAK-STAT Compound Library

252 compounds
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;
L2800 Serotonin Receptor-Targeted Compound Library

268 compounds
A unique collection of 268 compounds targeting serotonin receptors for high throughput screening and high content screening;
L7500 Coagulation and Anticoagulation Compound Library

144 compounds
A unique collection of 144 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS);
L4300 Wnt/Hedgehog/Notch Compound Library

237 compounds
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
L2170 Immuno-Oncology Compound Library

449 compounds
A unique collection of 449 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening;