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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T0432 | Diclofenac diethylamine | Apoptosis , COX | |
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID). | |||
T0196 | Diclofenac | Diclofenacum,Voltaren | Apoptosis , COX |
Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of a... | |||
T6470 | Diclofenac Potassium | CGP-45840B,Cataflam,Voltfast | Apoptosis , Others , COX |
Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. | |||
T1555 | Diclofenac sodium | GP 45840 | Apoptosis , COX |
Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. | |||
T24784 | SF5 | SF-5,SF 5 | Apoptosis |
SF5 is an inhibitor of the apoptosis pathway. Which is through the JNK-p53-caspase apoptotic cascade. | |||
T7582 | Tafamidis meglumine | Fx-1006A | Others |
Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade | |||
T8570 | L524-0366 | [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone | Others |
L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor. | |||
T8428 | Subasumstat | TAK-981 | E1/E2/E3 Enzyme |
Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities. | |||
T2648 | Pimecrolimus | SDZ-ASM 981,ASM 981 | Others |
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri... | |||
T124384 | Jasmonic acid | (-)-Jasmonic acid | |
Jasmonic acid (JA) is a phytohormone and plant growth regulator involved in plant defense and growth and development.Jasmonic acid plays an important role in signaling, inducing the MAP kinase cascade pathway and calcium... | |||
T26629 | Angstrom6 | A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide | PAI-1 |
Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and abrogates the downstream effects.Angstrom6 has antitumor a... | |||
T11994 | Melagatran | Thrombin | |
Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinolytic enzymes. It does not rely on endogenous co-factors to e... | |||
T9014 | SKI-178 | Apoptosis , S1P Receptor | |
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ... | |||
T40063 | CBR-470-1 | Nrf2 | |
CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protect... | |||
T3560 | Desmethylanethol trithione | ADT-OH | VEGFR , Akt |
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly... | |||
T2170 | SKF-96365 hydrochloride | SKF96365 | Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy |
SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha... | |||
T69500 | YO-2 | ||
YO-2 is a selective plasmin inhibitor. YO-2 induces thymocyte apoptosis via activation of caspase cascade. | |||
T76953 | Xeligekimab | ||
Xeligekimab (GR 1501) is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A) to inhibit the pro-inflammatory cascade [1]. | |||
TP1950 | PEN(mouse) | PEN (mouse) | |
Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide. Activates phospholipase C (PLC)-mediated signaling cascade in mouse hypothalamus. | |||
T25377 | EP6 | EP-6,EP 6 | |
EP6 is an inhibitor of 5-lipoxygenase (5-LO), which is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and all... | |||
T64001 | MAP855 | ||
MAP855 is a potent, selective, orally active, ATP-competitive MEK1/2 kinase inhibitor with an IC50 value of 3 nM for MEK1 ERK2 cascade and a pERKEC50 value of 5 nM. MAP855 exhibits equal inhibition of wild-type and mutan... | |||
T36331 | Z-AEVD-FMK | Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone | |
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its activ... | |||
T25050 | Alloferon 3 | ||
Alloferon 3 is a natural peptide that mediates signaling by the NF-kappa B pathway to enhance the recognition of viral and tumor antigens. It is known to induce the production of endogenic interferons that promote a casc... | |||
T70234 | Cacospongionolide B | ||
Cacospongionolide B is isolated from the sponge Fasciospongia cavernosa. The marine sponge natural product cacospongionolide B (1) is one of a class of compounds bearing a g-hydroxybutenolide which are known to inhibit m... | |||
T68267 | RO5068760 | ||
RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen... | |||
T37556 | CAY10502 | ||
Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme tha... | |||
T22676 | Prothrombin (474-477) [Mus musculus] | Others | |
Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothro... | |||
T78924 | TPE-1p | ||
TPE-1p, a cascade-activated AIEgen-peptide probe, self-assembles in aqueous solution to produce bright fluorescence upon interaction with alkaline phosphatase (ALP) and ChT-L. It facilitates noninvasive evaluation of ChT... | |||
T76273 | Pep19-2.5 | ||
Pep19-2.5, a synthetic antitoxin peptide, inhibits the intracellular signaling cascade triggered by endotoxins by blocking the activity of lipopeptides (LP) and lipopolysaccharides (LPS) mediated through both transmembra... | |||
T74068 | WH-15 | ||
WH-15 is a fluorogenic phospholipase C (PLC) reporter, exhibiting Michaelis-Menten constant (Km) values of 49, 30, and 86.1 µM for PLC-γ1, PLC-δ1, and PLC-β2, respectively. It undergoes enzymatic cleavage in a cascade re... | |||
T73701 | Urokinase (peptidolytic) | ||
Urokinase peptidolytic (Urokinase-type plasminogen activator) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in t... | |||
T76059 | SAH-SOS1A TFA | ||
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA di... | |||
T37030 | PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) | PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) | |
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dio... | |||
T78007 | Vasonatrin Peptide (VNP) TFA | ||
Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, ... | |||
T37026 | Mesalamine impurity P | ||
Mesalamine impurity P is an impurity of Mesalamine . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1]. [1]. Kyle Dammann, et al.PAK1 modulat... | |||
T36937 | PtdIns-(1,2-dioctanoyl) (sodium salt) | ||
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl... | |||
T74844 | Antiproliferative agent-23 | ||
Antiproliferative agent-23, a microtubule-destabilizing agent (MDA), disrupts the tubulin-microtubule system, leading to apoptosis through a mitochondrion-dependent pathway. This involves downregulation of Bcl-2 protein,... | |||
T35491 | 3,5-dimethyl PIT-1 | ||
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is impor... | |||
T64692 | AMY-101 acetate | ||
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exe... | |||
T37367 | Amyloid-β (1-42) Peptide (trifluoroacetate salt) | ||
Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of ne... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T7982 | 3,6-Dihydroxyflavone | Others | |
3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway. | |||
T6S1844 | Tenacissoside H | Tenacissimoside C | Others |
Tenacissoside H (Tenacissimoside C) has antitumor activity on esophageal cancer through arresting cell cycle and regulating PI3K/Akt-NF-κB transduction cascade. | |||
T6S1740 | Nardosinone | Others | |
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t... | |||
T27305 | Fascaplysin chloride | NSC622398,NSC 622398,Fascaplysin,NSC-622398 | |
Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human ... | |||
T1033L | Monensin | Elancoban,Rumensin | |
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with d... | |||
TN4410 | Lappaol C | P-gp , JNK | |
Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidat... | |||
TN1072 | Lappaol A | P-gp , JNK | |
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidat... | |||
T73717 | CGAMP diammonium | ||
cGAMP (Cyclic GMP-AMPP) diammonium serves as an intrinsic second messenger in metazoans, initiating the production of interferons upon cytosolic DNA detection. It activates the stimulator of interferon genes (STING), sub... | |||
TMA0984 | Cerevisterol | DNA/RNA Synthesis | |
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. | |||
T75600 | Coronatine | ||
Coronatine is a plant growth regulator synthesized by Pseudomonas syringae, mimicking bioactive jasmonic acid conjugates or octadecanoid signal molecules in higher plants, which induces pathogenic symptoms. It enhances t... | |||
TN4411 | Lappaol F | CDK , P-gp , JNK | |
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be c... | |||
T36954 | Nemorosone | ||
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma ce... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-01101 | Coagulation factor X/F10 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the... | |||
TMPY-01964 | CD16a Protein, Human, Recombinant (F176V, His) | Human | HEK293 Cells |
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also ... | |||
TMPY-01806 | CD9 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPJ-00375 | HGF Protein, Human, Recombinant (His) | Human | HEK293 Cells |
HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti... | |||
TMPY-02185 | Coagulation factor XIII B/F13B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ... | |||
TMPH-02250 | TPP2 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus Insect Cells |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ... | |||
TMPH-01909 | CPVL Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. CPVL Protein, Human, Recombinant (His & SU... | |||
TMPK-00020 | CD59 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD59 regulates complement activation cascade at the final step, inhibiting formation of membrane attack complex (MAC). This protein, being anchored to the cell membrane via glycosyl phosphatidyl inositol (GPI), is expres... | |||
TMPK-01263 | B7-H7 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances ... | |||
TMPH-01295 | Endothelin-1/EDN1 Protein, Human, Recombinant (GST) | Human | E. coli |
Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial... | |||
TMPJ-01383 | Serpin A10 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits f... | |||
TMPH-01385 | GLP1R Protein, Human, Recombinant (His) | Human | HEK293 Cells |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ... | |||
TMPH-03757 | TPP2 Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ... | |||
TMPH-03287 | EPOR Protein, Rat, Recombinant (His & SUMO) | Rat | E. coli |
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also ... | |||
TMPH-00938 | ANXA5 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. ANXA5 Protein, Human, Recombinant (His) is expressed... | |||
TMPH-01692 | MAPK3 Protein, Human, Recombinant (His) | Human | E. coli |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate... | |||
TMPK-01370 | GRP-10 proform Protein, Canine, Recombinant (hFc) | Canine | HEK293 Cells |
Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have previously been suggested to play a role in the complex cascade of chemical activity associated... | |||
TMPY-02252 | LAMTOR2 Protein, Human, Recombinant (His) | Human | E. coli |
Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-... | |||
TMPJ-00770 | Granzyme B/GZMB Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an... | |||
TMPH-02881 | Renin-2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood... | |||
TMPH-03286 | Endothelin-1/EDN1 Protein, Rat, Recombinant (His & KSI) | Rat | E. coli |
Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial... | |||
TMPK-01271 | Coagulation factor XI Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to FXIa by factor XIIa (FXIIa), a co... | |||
TMPH-01447 | Human herpesvirus 2 (HHV-2) (strain HG52) Envelope glycoprotein C (His) | HHV-2 | E. coli |
Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Plays also a role in host immune evasion by inhibiting the host complement cascade activation. Human her... | |||
TMPK-00151 | Complement Factor D/CFD Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPJ-01176 | SEMA4C Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Semaphorin-4C is a protein which belongs to the semaphorin family, contains 1 Ig-like C2-type domain, 1 PSI domain, 1 Sema domain. As cell surface receptor for PLXNB2, it plays an important role in cell-cell signaling. P... | |||
TMPH-03762 | TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc) | Mouse | E. coli |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ... | |||
TMPH-02953 | TPP2 Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ... | |||
TMPK-00276 | TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting d... | |||
TMPH-03301 | GLP1R Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ... | |||
TMPH-02676 | GLP1R Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ... | |||
TMPH-01384 | GLP1R Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ... | |||
TMPJ-00396 | SEMA4D Protein, Human, Recombinant (aa 22-734, His) | Human | HEK293 Cells |
Semaphorin-4D is also known as A8,BB18, GR3, CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain, 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB... | |||
TMPH-02270 | Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melan... | |||
TMPH-02269 | Tyrosinase/TYR Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melan... | |||
TMPH-01250 | MAP2K3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that... | |||
TMPH-02898 | SPINK2 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defe... | |||
TMPK-00277 | TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter mol... | |||
TMPJ-00163 | R-Spondin 3/RSPO3 Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells |
R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 rep... | |||
TMPK-00671 | Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His) | Rhesus | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPK-00755 | Complement Factor D/CFD Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge... | |||
TMPH-00779 | IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc) | Guinea pig | E. coli |
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 b... | |||
TMPJ-00844 | ANXA8 Protein, Human, Recombinant | Human | E. coli |
Annexin A8 (ANXA8) belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Annexin A8 contains 4 annexin repeats separated by linking sequences of variable lengths. A pair of annexin repeats ... | |||
TMPJ-01378 | Mp1 Protein, Human, Recombinant (His) | Human | E. coli |
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding pro... | |||
TMPK-00115 | CD79B Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
CD79B (also known as B29, Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily. It is required in cooperation with CD79A for initiation of the signal tran... | |||
TMPH-02606 | CR1L Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor,... | |||
TMPJ-01125 | PEA15 Protein, Human, Recombinant | Human | E. coli |
Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis... | |||
TMPH-02697 | GNA12 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). G... | |||
TMPJ-00080 | IL-11 Protein, Human, Recombinant (P. pastoris) | Human | P. pastoris (Yeast) |
Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that dir... | |||
TMPH-02226 | TEAD3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is... | |||
TMPJ-00215 | Fas/CD95 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L3700 | JAK-STAT Compound Library | 252 compounds | |
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening; | |||
L2800 | Serotonin Receptor-Targeted Compound Library | 268 compounds | |
A unique collection of 268 compounds targeting serotonin receptors for high throughput screening and high content screening; | |||
L7500 | Coagulation and Anticoagulation Compound Library | 144 compounds | |
A unique collection of 144 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L4300 | Wnt/Hedgehog/Notch Compound Library | 237 compounds | |
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; | |||
L2170 | Immuno-Oncology Compound Library | 449 compounds | |
A unique collection of 449 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening; |