|
T9043 |
AS1810722
|
|
P450
,
STAT
|
|
AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhibition of CYP3A4, positioning it as a promising candidate f... |
|
T4657 |
WHI-P97
|
|
JAK
|
|
WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ... |
|
T9962 |
Mepolizumab
|
SB 240563 |
IL Receptor
|
|
Mepolizumab (SB 240563) is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in studies about severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis. |
|
T25465 |
GS143
|
GS-143,GS 143 |
IκB/IKK
,
E1/E2/E3 Enzyme
,
NF-κB
|
|
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea... |
|
T9416 |
Dansylglycine
|
|
Others
|
|
Dansylglycine is a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase[1]. |
|
T9239 |
RS-25344
|
|
PDE
|
|
RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro. |
|
T9084 |
Cetirizine Impurity B dihydrochloride
|
De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride |
Histamine Receptor
|
|
Cetirizine Impurity B dihydrochloride (De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride) is an impurity of Cetirizine dihydrochloride. Cetirizine is a second-generation antihistamine. Cetirizine is a specific, o... |
|
T20752 |
Biebrich scarlet
|
NSC-79710,NSC79710,NSC 79710 |
|
|
Biebrich scarlet is a scarlet dye, it has been used in Masson’s trichrome stain for the staining of collagen. It has also been used for the staining of eosinophil. |
|
T28221 |
NVP-QAV-680
|
NVP-QAV680,QAV690 free acid,NVP,QAV-690 free acid,NVPQAV680,QAV 690 free acid |
|
|
NVP-QAV-680 is a potent and selective antagonist of CRTh2 receptor. NVP-QAV-680 has nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro. |
|
T27638 |
Israpafant
|
Y-24180,Y 24180,Y24180 |
|
|
Israpafant is a selective antagonist for the platelet-activating factor receptor ( IC50 = 0.84nM). Israpafant inhibits PAF-induced human platelet aggregation. Israpafant inhibits the activation of eosinophil cells and co... |
|
T40430 |
Cetirizine Impurity D
|
|
|
|
Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine is a second-generation antihistamine that acts as a specific, orally active, and long-acting antagonist of the histamine H1-receptor. Cetirizine exhibits ant... |
|
T37156 |
8(S),15(S)-DiHETE
|
|
|
|
8(S),15(S)-DiHETE is formed when 15(S)-HETE is subjected to further oxidation by 15-LO. It causes eosinophil chemotaxis with an ED50 value of 1.5 μM but is not chemotactic for neutrophils. 8(S),15(S)-DiHETE antagonizes t... |
|
TP2008 |
Lyn peptide inhibitor
|
|
|
|
Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinoph... |
|
T37264 |
15(R)-15-methyl Prostaglandin D2
|
15(R)15methyl PGD2 |
GPR
|
|
15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis. |
|
T23154 |
Piclamilast
|
RPR 73401,RP 73401 |
PDE
|
|
Piclamilast (RP 73401) is a PDE4 inhibitor. |
|
T79185 |
STAT6-IN-2
|
|
STAT
|
|
STAT6-IN-2 (Comp R-84) serves as a STAT6 inhibitor, effectively reducing the secretion of the chemokine eotaxin-3, which is known to induce eosinophil infiltration. This compound is useful in the study of immune diseases... |
|
T79618 |
M3/PDE4 modulator-1
|
|
|
|
M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor. When administered intravenously at concentrations ranging from 10 to 1000 nM/kg, this co... |
|
T80599 |
Dectrekumab
|
QAX576 |
|
|
Dectrekumab (QAX576), a humanized monoclonal antibody targeting IL-13, significantly reduces intraepithelial esophageal eosinophil counts and normalizes dysregulated esophageal disease-related transcripts in Eosinophilic... |
|
T71329 |
Theophylline-d6
|
|
|
|
Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist... |
|
T36764 |
PAF C-18:1
|
|
|
|
PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the ... |
|
T80959 |
Trabikibart
|
CSL311 |
|
|
Trabikibart (CSL311), a βc-specific, fully human monoclonal antibody, specifically binds to the cytokine-binding epitope of the human βc receptor with picomolar affinity. It potently inhibits the collective impact of IL-... |
|
T69262 |
ABE171
|
|
|
|
ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) v... |
|
T72145 |
Montelukast dicyclohexylamine
|
MK0476 dicyclohexylamine |
|
|
Montelukast dicyclohexylamine (MK0476), a potent, selective, and orally active antagonist of the cysteinyl leukotriene receptor 1 (CysLT1), is utilized in the research of asthma, liver injury, and COVID-19. It exhibits a... |
|
T38350 |
TAS 205
|
|
|
|
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS ... |
|
T38365 |
CAY10597
|
|
|
|
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and... |
|
T38100 |
Betamethasone 21-phosphate (sodium salt hydrate)
|
|
|
|
Betamethasone 21-phosphate is a synthetic glucocorticoid.1It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model o... |
