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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T8747	Levofloxacin hydrochloride		DNA gyrase , Topoisomerase
	Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh...		DNA gyrase , Topoisomerase
T6828	ZL0420		Epigenetic Reader Domain
	ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with nanomolar binding affinities to bromodomains (BDs) of BRD4. ZL0420 has IC 50 values of 27 nM against BRD4 BD1 and 32 nM against B...		Epigenetic Reader Domain
T11179	Elubrixin	SB-656933	IL Receptor , CXCR
	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat...		IL Receptor , CXCR
T8462	Enoximone		PDE
	Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.		PDE
T60072	ZL0590		Epigenetic Reader Domain
	ZL0590 is an effective and selective inhibitor of BD1-BRD4 (IC50 = 90 nM) with anti-inflammatory activities.		Epigenetic Reader Domain
T7954	YM976		PDE
	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)		PDE
T15418	GS-6201	CVT-6883	Adenosine Receptor
	GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM.		Adenosine Receptor
T4657	WHI-P97		JAK
	WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ...		JAK
T1682	Methacholine Chloride	Mecholyl chloride,Acetyl-β-methylcholine chloride	AChR
	Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower r...		AChR
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T1083L	Theophylline monohydrate	Quibron	HDAC , PDE , Adenosine Receptor
	Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ...		HDAC , PDE , Adenosine Receptor
T1451	Levofloxacin hydrate	Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate	DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
	Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial c...		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
T21433	Stepronin	Prostenoglycine,Tiofacic,Tiase,TTPG	Others
	Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.		Others
T21060L	NPC 567 acetate	NPC 567 acetate(109333-26-8 Free base)	Bradykinin Receptor
	NPC 567 acetate is a bradykinin B2 antagonist and can be used in studies about the treatment of allergic airway disease.		Bradykinin Receptor
T68129L1	Picumeterol FA	Picumeterol FA(130641-36-0 Free base)	Adrenergic Receptor
	picumeterol FA is a potent and selective β2-adrenergic receptor agonist. In in vitro and in vivo tests, picumeterol FA produces long-lasting airway smooth muscle relaxation. picumeterol FA is a pure R-enantiomer and can ...		Adrenergic Receptor
T2526	Ciclesonide	Zetonna,RPR251526,Omnaris,Alvesco	Glucocorticoid Receptor
	Ciclesonide (Alvesco)(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.		Glucocorticoid Receptor
T6105	Phosphorylcholine chloride	phosphorylcholine,Phosphocholine chloride	Others
	Phosphorylcholine chloride, an antigenic component found on the surface of numerous commensal and pathogenic bacteria inhabiting the upper airway, is integral to bacterial cell surfaces.		Others
T16564	PPADS tetrasodium		P2X Receptor , Na+/Ca2+ Exchanger
	PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma in...		P2X Receptor , Na+/Ca2+ Exchanger
T77045	Itepekimab	REGN-3500,SAR-440340	Others
	Itepekimab (REGN-3500) is a potent monoclonal antibody against IL-33.Itepekimab reduces airway inflammation and associated tissue damage in in vivo experiments and can be used to study asthma.		Others
T31719	Etiprednol dicloacetate	BNP 166,BNP166,BNP-166	Others
	Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as ...		Others
T35258	YM 16638	YM 638,YM-16638,YM16638	LTR
	YM 16638 is an orally active leukotriene (LT) antagonist with triglyceride-lowering and peroxisome-increasing effects that can be used to study antigen-induced early and late airway responses in allergic sheep.		LTR
T68128	Picumast
	Picumast shows antiallergic activity and can be utilized in the treatment of asthma. Picumast may be used in the treatment of therapeutic allergic airway diseases.
T2391	Camostat mesylate	FOY-S980,FOY305,Camostat mesilate	Serine/threonin kinase , SARS-CoV , Sodium Channel
	Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.		Serine/threonin kinase , SARS-CoV , Sodium Channel
T39766	Nor-NOHA monoacetate	Nor NOHA monoacetate,Nω-Hydroxy-nor-L-arginine monoacetate	Arginase
	nor-NOHA monoacetate (Nω-Hydroxy-nor-L-arginine) is a highly potent and selective arginase inhibitor. nor-NOHA monoacetate inhibits rat hepatic arginase and inhibits the hydrolysis of L-arginine, which can be used to stu...		Arginase
T10110	3-CPs	3-Carbethoxypsoralen,3-Ethoxycarbonylpsoralen	Antibiotic
	3-CPs (3-Carbethoxypsoralen) is a bleomycin-induced serotypic podoplanar polysaccharide in mouse lung fibrosis that belongs to the psoralen family and interferes with antibody-mediated bacterial killing.3-CPs delays bleo...		Antibiotic
T16379	Oglemilast	GRC 3886	PDE
	Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 0.5 nM ...		PDE
T36503	Sodium Hydrogen Sulfide (hydrate)		Others
	Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sul...		Others
T67959	Pirodomast		Thrombin , Serine Protease
	Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospas...		Thrombin , Serine Protease
T6707	Tiotropium Bromide hydrate	BA-679 BR hydrate,BA 679BR	AChR
	Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a...		AChR
T31072	CP-664511	UNII-W1AEF8025F,CP664511
	CP-664511 is an alpha4beta1/ vascular cell adhesion molecule-1 (VCAM-1) inhibitor with therapeutic potential for allergic airway disease.
T28243	Ono 6240	Ono-6240,Ono6240
	Ono 6240 is an antagonist of platelet-activating factor. Ono 6240 prevents airway eosinophilia by inhibiting production of IL-2 and IL-5.
T28878	Sul-121 HCl	Sul-121 Hydrochloride
	Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidati...
T39684	AZD8154	AZD8154
	AZD8154 is a newly developed inhaled compound that selectively inhibits dual PI3Kγδ, aimed at treating airway inflammatory diseases.
T70333	PM-43I
	PM-43I is a potent inhibitor of both STAT5- and STAT6-dependent allergic airway disease in mice.
T61208	PDE4-IN-11
	PDE4-IN-11 is a potent phosphodiesterase isoenzyme 4 (PDE4) inhibitor, exhibiting remarkable bronchodilatory and anti-inflammatory characteristics. It is specifically designed for studying obstructive or inflammatory air...
T32156	Indimilast
	Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cel...
T68270	Avutometinib potassium
	Avutometinib potassium is a MEK inhibitor (MEKi) that enhanced the inhibition of pseudovirus infection by GLPG-0187. It Blocks SARS-CoV-2 Delta and Omicron Pseudovirus Infection of Airway Epithelial Cells In Vitro, Which...
T78822	JT002		NOD-like Receptor (NLR)
	JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLR...		NOD-like Receptor (NLR)
T72111	Ala-Ala-Pro-Val-chloromethylketone	AAPV-CMK
	Ala-Ala-Pro-Val-chloromethylketone serves as an irreversible inhibitor of human neutrophil elastase (NE), utilized in researching chronic inflammatory airway diseases.
T61794	LASSBio-1632
	LASSBio-1632 is a novel anti-asthmatic lead candidate that selectively inhibits PDE4A and PDE4D isoenzymes, leading to the suppression of airway hyper-reactivity (AHR) and TNF-α production in lung tissue. With high exper...
T28251	ONO-8809	ONO8809
	ONO-8809 is a thromboxane A2 receptor antagonist. ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner. Macrophage accumulation and matrix metalloproteinase-9 (MMP-9) act...
T12771	RS-601		Leukotriene Receptor , Thrombin
	RS-601 is a potent dual leukotriene D4/thromboxane A2 inhibitor that inhibits antigen-induced airway hyperresponsiveness (AHR) and shows asthmatic effects in a guinea pig model of asthma.		Leukotriene Receptor , Thrombin
T68129	Picumeterol	GR 114297A	Adrenergic Receptor
	Picumeterol（GR 114297A） is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that ca...		Adrenergic Receptor
T41121	Elubrixin tosylate	SB-656933 tosylate,Elubrixin tosylate
	Elubrixin tosylate (SB-656933 tosylate) is a high-potency, selective, competitive, and reversible CXCR2 antagonist, as well as an antagonist of the IL-8 receptor. It effectively inhibits upregulation of neutrophil CD11b ...
T37228	(±)8(9)-EpETE
	Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle b...
T75729	Neurokinin A TFA
	Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter belonging to the tachykinin family, functions through the NK-2 receptor. It serves as a significant mediator in human airway and gastrointestinal tissues [1]...
T11240	Ethacrynic acid D5		Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effec...		Others
T76320	FIZZ-1 (32-51) (mouse)
	FIZZ-1 (32-51) (mouse), a cysteine-rich secretory protein, is predominantly expressed in macrophages, bronchial epithelial, and type II alveolar epithelial cells (AEC) during allergic airway inflammation. Additionally, i...
T76435	Biotin-NeurokininA
	Biotin-Neurokinin A, a biotinylated form of Neurokinin A (Substance K), functions as a peptide neurotransmitter within the tachykinin family, primarily engaging the NK-2 receptor. It serves as a significant mediator in t...
T78371	Ac2-26 ammonium
	Ac2-26 ammonium, an N-terminal peptide of annexin 1, exhibits anti-inflammatory properties, reduces IKKβ protein levels in lysosomes via chaperone-mediated autophagy (CMA), improves lung ischemia-reperfusion injury outco...

Compounds

Levofloxacin hydrochloride

T8747

Synonym:

Target: DNA gyrase, Topoisomerase

ZL0420

T6828

Synonym:

Target: Epigenetic Reader Domain

Elubrixin

T11179

Synonym: SB-656933

Target: IL Receptor, CXCR

Target: Epigenetic Reader Domain

Target: Adenosine Receptor

Methacholine Chloride

T1682

Synonym: Mecholyl chloride,Acetyl-β-methylcholine chloride

Target: AChR

GS143

T25465

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

Theophylline monohydrate

T1083L

Synonym: Quibron

Target: HDAC, PDE, Adenosine Receptor

Levofloxacin hydrate

T1451

Synonym: Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Stepronin

T21433

Synonym: Prostenoglycine,Tiofacic,Tiase,TTPG

Target: Others

NPC 567 acetate

T21060L

Synonym: NPC 567 acetate(109333-26-8 Free base)

Target: Bradykinin Receptor

Picumeterol FA

T68129L1

Synonym: Picumeterol FA(130641-36-0 Free base)

Target: Adrenergic Receptor

Ciclesonide

T2526

Synonym: Zetonna,RPR251526,Omnaris,Alvesco

Target: Glucocorticoid Receptor

Phosphorylcholine chloride

T6105

Synonym: phosphorylcholine,Phosphocholine chloride

Target: P2X Receptor, Na+/Ca2+ Exchanger

Itepekimab

T77045

Synonym: REGN-3500,SAR-440340

Target: Others

Etiprednol dicloacetate

T31719

Synonym: BNP 166,BNP166,BNP-166

Target: Others

YM 16638

T35258

Synonym: YM 638,YM-16638,YM16638

Synonym: FOY-S980,FOY305,Camostat mesilate

Target: Serine/threonin kinase, SARS-CoV, Sodium Channel

Nor-NOHA monoacetate

T39766

Synonym: Nor NOHA monoacetate,Nω-Hydroxy-nor-L-arginine monoacetate

Target: Arginase

3-CPs

T10110

Synonym: 3-Carbethoxypsoralen,3-Ethoxycarbonylpsoralen

Sodium Hydrogen Sulfide (hydrate)

Target: Thrombin, Serine Protease

Tiotropium Bromide hydrate

T6707

Synonym: BA-679 BR hydrate,BA 679BR

Target: AChR

CP-664511

T31072

Synonym: UNII-W1AEF8025F,CP664511

Target:

Ono 6240

T28243

Synonym: Ono-6240,Ono6240

Target:

Sul-121 HCl

T28878

Synonym: Sul-121 Hydrochloride

Avutometinib potassium

Target: NOD-like Receptor (NLR)

Ala-Ala-Pro-Val-chloromethylketone

Target: Leukotriene Receptor, Thrombin

Picumeterol

T68129

Synonym: GR 114297A

Target: Adrenergic Receptor

Elubrixin tosylate

T41121

Synonym: SB-656933 tosylate,Elubrixin tosylate

FIZZ-1 (32-51) (mouse)

カタログ番号	製品名	別名	ターゲット
TN1416	Ayanin		IL Receptor , P450 , PARP , PDE
	Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 productio...		IL Receptor , P450 , PARP , PDE
T3872	Nodakenin	(+)-Marmesinin	AChE
	Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.		AChE
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
T5758	Sphondin		COX , Prostaglandin Receptor
	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.		COX , Prostaglandin Receptor
T1083	Theophylline	Theo-24,1,3-Dimethylxanthine	Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy
	Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3...
T6567	Levofloxacin	Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin	Topoisomerase , Antibacterial , Antibiotic
	Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.		Topoisomerase , Antibacterial , Antibiotic
T4S2164	Narirutin	Naringenin-7-O-rutinoside,Isonaringin	Others , Antibacterial
	1. Narirutin (Naringenin-7-O-rutinoside) has antiproliferative property. 2. Narirutin has anti-oxidant property. 3. Narirutin has anti-allergic and anti-inflammatory properties , can reduce airway inflammation in ovalbum...		Others , Antibacterial
TMA1570	Sappanone A		NF-κB , Nrf2
	Sappanone A is a high isoflavanone that exhibits anti-inflammatory effects by modulating Nrf2.Sappanone A attenuates allergic airway inflammation in ovalbumin-induced asthma.		NF-κB , Nrf2
T3821	Deapioplatycodin D	Deapi-platycodin D,DesapioplatycodinD	Others , HCV Protease
	Deapioplatycodin D and platycodin D can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extract of APG as expectorants in diverse inflammatory pulmonar...		Others , HCV Protease
T2S2108	Coixol	6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA	Others , Antibacterial
	1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate fo...		Others , Antibacterial
TN2089	Platycodin D3		HCV Protease , NF-κB
	Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway mucin; it can significantly enhance mitogen- and OVA-induced...		HCV Protease , NF-κB
T2978	Mogroside V		AMPK
	Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induce...		AMPK
T4S0998	Trifolirhizin		TNF , Tyrosinase
	Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirhizin possesses potential anti-inflammatory and anti-cancer ...		TNF , Tyrosinase
T3889	Platycodin D		Prostaglandin Receptor , AMPK
	Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 1...		Prostaglandin Receptor , AMPK
T6S0077	Byakangelicol		COX
	1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...		COX
T37974	(S)-Coriolic acid	13(S)-HODE	Lipoxygenase , Mitochondrial Metabolism , PPAR
	(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involved in cell proliferation and differentiation i...		Lipoxygenase , Mitochondrial Metabolism , PPAR
TN1273	7,4'-Dihydroxyflavone	4',7-Dihydroxyflavone	NF-κB , COX , HDAC , CCR , NOD
	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.		NF-κB , COX , HDAC , CCR , NOD
T40787	Platyconic acid A
	Platyconic Acid A, derived from changkil saponins extracted from platycodon grandiflorum, is a potent compound employed for studying the mitigation of airway inflammation.
TN2974	3-O-Methylquercetin tetraacetate		IL Receptor , TNF , PDE
	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.		IL Receptor , TNF , PDE
TN4819	(-)-Praeruptorin A		ATPase , IL Receptor , Calcium Channel , P-gp
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can ...		ATPase , IL Receptor , Calcium Channel , P-gp
T11124	Duramycin	Lancovutide,Moli1901	Others
	Duramycin is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects. Duramycin stimulates chloride secretion ...		Others
TN2511	Britannilactone diacetate	1,6-O,O-Diacetylbritannilactone	IL Receptor , PARP , ROS , MAPK , Caspase , JAK , JNK , STAT
	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic acti...
TN4489	Manassantin A		ERK , cAMP , TNF , NF-κB , MAPK , COX , HIF , Prostaglandin Receptor , JNK , STAT
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibitio...
T13606L	CGAMP disodium
	cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I inte...

天然物製品

Ayanin

TN1416

Synonym:

Target: IL Receptor, P450, PARP, PDE

Nodakenin

T3872

Synonym: (+)-Marmesinin

Target: Antioxidant, NF-κB

Sulfuretin

TN2244

Synonym:

Target: NF-κB, Autophagy

sphondin

T5758

Synonym:

Target: COX, Prostaglandin Receptor

Theophylline

T1083

Synonym: Theo-24,1,3-Dimethylxanthine

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Levofloxacin

T6567

Synonym: Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin

Target: Topoisomerase, Antibacterial, Antibiotic

Narirutin

T4S2164

Synonym: Naringenin-7-O-rutinoside,Isonaringin

Target: Others, Antibacterial

Synonym: Deapi-platycodin D,DesapioplatycodinD

Target: Others, HCV Protease

Coixol

T2S2108

Synonym: 6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA

Target: Others, Antibacterial

Platycodin D3

TN2089

Synonym:

Target: HCV Protease, NF-κB

Target: TNF, Tyrosinase

Platycodin D

T3889

Synonym:

Target: Prostaglandin Receptor, AMPK

Target: Lipoxygenase, Mitochondrial Metabolism, PPAR

7,4'-Dihydroxyflavone

TN1273

Synonym: 4',7-Dihydroxyflavone

Target: NF-κB, COX, HDAC, CCR, NOD

3-O-Methylquercetin tetraacetate

TN2974

Synonym:

Target: IL Receptor, TNF, PDE

(-)-Praeruptorin A

TN4819

Synonym:

Target: ATPase, IL Receptor, Calcium Channel, P-gp

Duramycin

T11124

Synonym: Lancovutide,Moli1901

Target: Others

Britannilactone diacetate

TN2511

Synonym: 1,6-O,O-Diacetylbritannilactone

Target: IL Receptor, PARP, ROS, MAPK, Caspase, JAK, JNK, STAT

Manassantin A

TN4489

Synonym:

Target: ERK, cAMP, TNF, NF-κB, MAPK, COX, HIF, Prostaglandin Receptor, JNK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-01203	HATL5 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Transmembrane Protease Serine 11B (TMPRSS11B) is a single-pass type II membrane protein member of the peptidase S1 family. TMPRSS11B contains one peptidase S1 domain and one SEA domain. TMPRSS11B is a serine protease tha...
TMPJ-01210	IL-33 Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identifi...
TMPH-01600	Lactoperoxidase/LPO Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May contribute to airway host defense against infection.
TMPJ-01233	AGR3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Anterior gradient protein 3 (AGR3) is an 18 kDa member of the AGR family of proteins. It is expressed in the ciliated cells of the airway epithelium, not detected in the mucous cells. Mature human AGR3 shares 92% amino a...
TMPJ-00423	TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily that cosisits 305 amino acid (aa). It is expressed by stimulated T-cells. TIM-1/KIM-1/HAVCR may play a role in T-helper cell development and the regulation of a...
TMPH-02708	HNMT Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. HNMT Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression s...
TMPK-01201	BPIFA1/LUNX Protein, Human, Recombinant	Human	E. coli
	Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submu...
TMPK-01202	CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated	Human	HEK293 Cells
	CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperrespons...
TMPK-00096	FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated	Human	E. coli
	Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling de...
TMPH-03753	MYLK Protein, Human, Recombinant (His)	Human	E. coli
	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos...
TMPK-00025	IL-9 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPY-01826	Relaxin 1/RLN1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein that belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductiv...
TMPH-02540	GRK2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to...
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His)	Human	E. coli
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules ...
TMPK-00026	IL-9 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPK-00568	IL-9 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPY-04205	AGR3 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associat...
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synth...
TMPH-02690	PLA2G10 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatid...