Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).
説明 | HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). |
ターゲット&IC50 | SAG:1.5μM, Shh:1.5μM, GLI2:4μM |
分子量 | 463.52 |
分子式 | C27H29NO6 |
CAS No. | 599150-20-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (140.23 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
HPI 1 599150-20-6 GPCR/G Protein Stem Cells Hedgehog/Smoothened SUM149 anti-proliferative inhibit colony formation HPI-1 Gli GLI1 mRNA HPI1 SUM159 cells GLI antagonist1 GLI antagonist-1 Inhibitor GLI antagonist 1 inhibitor